Výsledky vyhledávání

Templating peptide folding on the surface of a micelle: nucleating the formation of a beta-hairpin

Autor: M S, Searle, M, Jourdan

Publikováno v: Bioorganicmedicinal chemistry letters. 10(10)

NMR spectroscopy is used to show that a 20-residue beta-hairpin peptide sequence derived from ferredoxin I, with a Pro-Asp two-residue type I turn which is uncommon in beta-hairpins, is unstructured in aqueous solution but shows NOE evidence for part

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::018f078a36bae2b98e360ab7d61898a4
https://pubmed.ncbi.nlm.nih.gov/10843236

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Dissecting the stability of a beta-hairpin peptide that folds in water: NMR and molecular dynamics analysis of the beta-turn and beta-strand contributions to folding

Autor: S R, Griffiths-Jones, A J, Maynard, M S, Searle

Publikováno v: Journal of molecular biology. 292(5)

NMR studies of the folding and conformational properties of a beta-hairpin peptide, several peptide fragments of the hairpin, and sequence-modified analogues, have enabled the various contributions to beta-hairpin stability in water to be dissected.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::81a309002baaa0370a9074b1fb0055e9
https://pubmed.ncbi.nlm.nih.gov/10512702

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Solution structure and dynamics of the A-T tract DNA decamer duplex d(GGTAATTACC)2: implications for recognition by minor groove binding drugs

Autor: C E, Bostock-Smith, C A, Laughton, M S, Searle

Publikováno v: The Biochemical journal. 342

The structure of the DNA decamer duplex d(GGTAATTACC)(2) has been determined using NMR distance restraints and molecular dynamics simulations of 500 ps to 1 ns in aqueous solution at 300 K. Using both canonical A and canonical B starting structures [

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::8505345c456420fa199fe1d62baa45af
https://pubmed.ncbi.nlm.nih.gov/10432309

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Structure, dynamics and hydration of the nogalamycin-d(ATGCAT)2Complex determined by NMR and molecular dynamics simulations in solution

Autor: H E, Williams, M S, Searle

Publikováno v: Journal of molecular biology. 290(3)

The structure of the 1:1 nogalamycin:d(ATGCAT)2 complex has been determined in solution from high-resolution NMR data and restrained molecular dynamics (rMD) simulations using an explicit solvation model. The antibiotic intercalates at the 5'-TpG ste

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::5064e34bcac00819de1c728775e0abb3
https://pubmed.ncbi.nlm.nih.gov/10395824

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Structure/activity studies of the anti-MUC1 monoclonal antibody C595 and synthetic MUC1 mucin-core-related peptides and glycopeptides

Autor: D I, Spencer, S, Missailidis, G, Denton, A, Murray, K, Brady, C I, Matteis, M S, Searle, S J, Tendler, M R, Price

Publikováno v: Biospectroscopy. 5(2)

MUC1 mucin is a large complex glycoprotein expressed on normal epithelial cells in humans and overexpressed and under or aberrantly glycosylated on many malignant cancer cells which consequently allows recognition of the protein core by antibodies. I

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::08757a3498e8cf71f10b4e117a0b66fa
https://pubmed.ncbi.nlm.nih.gov/10217327

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Modulation of intrinsic phi,psi propensities of amino acids by neighbouring residues in the coil regions of protein structures: NMR analysis and dissection of a beta-hairpin peptide

Autor: S R, Griffiths-Jones, G J, Sharman, A J, Maynard, M S, Searle

Publikováno v: Journal of molecular biology. 284(5)

Analysis of residues in coil regions of protein structures presents a novel approach to deconvoluting the various competing factors which determine the intrinsic phi,psi propensities of amino acids free from the regular interactions associated with b

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::734d2b3971b3f2fff23ef24c407cf7c1
https://pubmed.ncbi.nlm.nih.gov/9878373

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A Polyproline II Motif is Determined in MUC1 Mucin Synthetic (Glyco)-Peptides Using CD And NMR

Autor: M. S. Searle, Sotiris Missailidis, Michael R. Price, C. De Matteis, D. I. R. Spencer, Saul J. B. Tendler

Publikováno v: Spectroscopy of Biological Molecules: Modern Trends ISBN: 9789401063692

MUC1 mucin is a heavily glycosylated glycoprotein found on the apical side of normal human epithelial cells but is aberrantly glycosylated and over-expressed on cancerous epithelial cells. It contains multiple repeats of the 20 amino acid sequence TA

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::cbba893d7f4220f8d5788207e127c6fc
https://doi.org/10.1007/978-94-011-5622-6_16

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The 'n' effect in molecular recognition

Autor: M S, Westwell, M S, Searle, D H, Williams

Publikováno v: Journal of molecular recognition : JMR. 9(2)

The cooperativity which exists in crystal melting and many biological molecular recognition phenomena arises from extended arrays of weak interactions. We present a correlation between the melting temperature of a crystal and the intermolecular energ

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::564d26d21c1950ab96b202a5bd267275
https://pubmed.ncbi.nlm.nih.gov/8877798

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From rhetoric to reality: moving hospitals into health promotion

Autor: M S, Searle, S, Boreskie, D, Lamont

Publikováno v: Leadership in health services = Leadership dans les services de sante. 4(2)

Health promotion has received a lot of attention over the past several decades as an important means of improving the health of Canadians and reducing the costs of health service delivery. How do hospitals reorient themselves to a greater role in hea

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::c2deec5cbbcaa69ca7f26a6a08aa6e7d
https://pubmed.ncbi.nlm.nih.gov/10141736

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