Zobrazeno 1 - 8
of 8
pro vyhledávání: '"M S, Osburne"'
Autor:
M S Osburne, P V Pallai, Majaz Moonis, S K Singh, K J Willis, Edith A. Neidhardt, J C Jenson, A T Profy, M. S. Hirsch, Stefano Rusconi, Debra P. Merrill
Publikováno v:
Scopus-Elsevier
PIC 024-4 and PRO 2000 are naphthalene sulfonate polymers that bind to CD4 with nanomolar affinity and block binding of gp120. Both have activity against human immunodeficiency virus type 1 in H9 cells, peripheral blood mononuclear cells, and primary
Autor:
I A, MacNeil, C L, Tiong, C, Minor, P R, August, T H, Grossman, K A, Loiacono, B A, Lynch, T, Phillips, S, Narula, R, Sundaramoorthi, A, Tyler, T, Aldredge, H, Long, M, Gilman, D, Holt, M S, Osburne
Publikováno v:
Journal of molecular microbiology and biotechnology. 3(2)
Natural products have been a critically important source of clinically relevant small molecule therapeutics. However, the discovery rate of novel structural classes of antimicrobial molecules has declined. Recently, increasing evidence has shown that
Autor:
P R, August, T H, Grossman, C, Minor, M P, Draper, I A, MacNeil, J M, Pemberton, K M, Call, D, Holt, M S, Osburne
Publikováno v:
Journal of molecular microbiology and biotechnology. 2(4)
Violacein is a purple-colored, broad-spectrum antibacterial pigment that has a dimeric structure composed of 5-hydroxyindole, oxindole and 2-pyyrolidone subunits formed by the condensation of two modified tryptophan molecules. The violacein biosynthe
Publikováno v:
Nature structural biology. 6(6)
Using NMR spectroscopy, we determined the solution structure of a single-chain T-cell receptor (scTCR) derived from the major histocompatibility complex (MHC) class II-restricted D10 TCR. The conformations of complementarity-determining regions (CDRs
Autor:
M S Osburne
Publikováno v:
Journal of Bacteriology. 151:1633-1636
Derivatives of Rhizobium meliloti 2011 required trace amounts of glutamate to use ammonium as the nitrogen source for growth, although they could use serine as the sole nitrogen source. Specific activities of ammonium assimilatory enzymes were simila
Publikováno v:
Journal of bacteriology. 170(1)
Whereas treatment with many different drugs led to induction of the SOS response in Bacillus subtilis, only inhibitors of DNA gyrase subunit B and, unexpectedly, polyether antibiotics (membrane ionophores) led to relaxation of supercoiled plasmid DNA
Autor:
E R Signer, M S Osburne
We have characterized a mutant of Rhizobium meliloti strain 2011 which cannot use ammonium as a nitrogen source. This mutant, RTm2620, was found to have significantly altered glutamate synthase activity. Both the mutant and the wild-type strains had
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12035d0f49240f343d4c557a1d2711bb
https://europepmc.org/articles/PMC294485/
https://europepmc.org/articles/PMC294485/
Publikováno v:
Journal of bacteriology. 163(3)
We describe a thermoinducible-expression system for Bacillus subtilis which utilized an early promoter-operator sequence from temperate phage phi 105 and the thermolabile prophage repressor from the phage variant phi 105 cts23. The system operated at