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Akademický článek

Targeting the PI3K/Akt/mTOR signalling pathway in Cystic Fibrosis

Autor: R. Reilly, M. S. Mroz, E. Dempsey, K. Wynne, S. J. Keely, E. F. McKone, C. Hiebel, C. Behl, J. A. Coppinger

Publikováno v: Scientific Reports, Vol 7, Iss 1, Pp 1-13 (2017)

Abstract Deletion of phenylalanine 508 of the cystic fibrosis transmembrane conductance regulator (ΔF508 CFTR) is a major cause of cystic fibrosis (CF), one of the most common inherited childhood diseases. ΔF508 CFTR is a trafficking mutant that is

Externí odkaz: https://doaj.org/article/83f7d91151ee4471ab8b716bf6da8bf0

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Chronic regulation of colonic epithelial secretory function by activation of G protein-coupled receptors

Autor: F, Toumi, M, Frankson, J B, Ward, O B, Kelly, M S, Mroz, L S, Bertelsen, S J, Keely

Publikováno v: Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society. 23(2)

Enteric neurotransmitters that act at G protein-coupled receptors (GPCRs) are well known to acutely promote epithelial Cl(-) and fluid secretion. Here we examined if acute GPCR activation might have more long-term consequences for epithelial secretor

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::c2ded8e9b3925f5a0f9010a40d7e3978
https://pubmed.ncbi.nlm.nih.gov/20939850

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