Zobrazeno 1 - 10
of 83
pro vyhledávání: '"M S, Kleven"'
Autor:
W. L. Woolverton, M. S. Kleven
Publikováno v:
Behavioural Pharmacology. 1:365-374
Rhesus monkeys were trained to press a lever in daily experimental sessions under a three-component multiple schedule of reinforcement. In the first and third components, food was available under a fixed-ratio (FR) 30 schedule. In the second componen
Autor:
G W, John, P J, Pauwels, M, Perez, S, Halazy, B, Le Grand, Y, Verscheure, J P, Valentin, C, Palmier, T, Wurch, P, Chopin, M, Marien, M S, Kleven, W, Koek, M B, Assie, E, Carilla-Durand, J P, Tarayre, F C, Colpaert
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 290(1)
F 11356 (4-[4-[2-(2-aminoethyl)-1H-indol-5-yloxyl]acetyl]piperazinyl-1-yl] ben zonitrile) was designed to take advantage of the superior potency and efficacy characteristics of 5-hydroxytryptamine (5-HT) compared with tryptamine at 5-HT1B/1D receptor
Autor:
M S, Kleven, W, Koek
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 284(3)
In this study we examined the ability of compounds varying in their in vitro potencies as inhibitors of dopamine (DA), norepinephrine (NE) or serotonin (5-HT) reuptake to enhance the discriminative stimulus (DS) effects of cocaine. Compounds were adm
Autor:
M S, Kleven, W, Koek
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 284(1)
In this study we examined the effects of 5-HT1A ligands in rats trained to discriminate 0.16 mg/kg i.p. 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT) from saline in a two-lever, fixed ratio (FR)10 schedule of food reinforcement, and in pigeons t
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 282(2)
To characterize their in vivo 5-hydroxytryptamine (5-HT)2A antagonist properties, the ability of the putative mixed 5-HT1A agonists/5-HT(2A,2C) antagonists (N-(29(4-(2-pyrimidinyl)-1-piperazinyl)ethyl)tricyclo(3.3.1.1(3,7) ) decane-1-carboxamide (WY-
Autor:
M S, Kleven, W, Koek
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 279(3)
Spontaneous eye blink rate was assessed in cynomolgus monkeys treated intramuscularly with the high-efficacy dopamine (DA) agonists, (-)-apomorphine, naxagolide, PD 128,907, 2-(N-phenylethyl-N-propyl)amino-5-hydroxytetralin (+/-)-PPHT, quinpirole, SK
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 276(3)
The present study investigated the effects of repeated administration of the dopamine reuptake inhibitors N-[1-(2-benzo(b)thiophenyl)cyclohexyl]piperidine (BTCP) and cocaine on locomotor activity, as well as their ability to induce or express cross-s
Autor:
M S, Kleven, W, Koek
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 276(2)
A conflict procedure in pigeons was used to characterize the antipunishment effects of the putative mixed 5-hydroxytryptamine (5-HT)1A agonist/5-HT2A/2C antagonists WY 50,324, CGS 18102A, LEK 8804 and FG 5974 and to further investigate interactions b
Autor:
W L, Woolverton, M S, Kleven
Publikováno v:
NIDA research monograph. 119
Pharmacological characterization of the discriminative stimulus effects of cocaine in rhesus monkeys
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 254(1)
Rhesus monkeys (n = 6), trained in a two-lever, food-reinforced paradigm to discriminate cocaine (0.2 or 0.4 mg/kg, i.m.) from saline, received injections of cocaine (0.025-0.40 mg/kg, i.v. or i.m.) or various direct and indirect acting agonists (i.v