Výsledky vyhledávání - "M S, Kasibhatla"

Dual role of glutathione in modulating camptothecin activity: depletion potentiates activity, but conjugation enhances the stability of the topoisomerase I-DNA cleavage complex

Autor: M P, Gamcsik, M S, Kasibhatla, D J, Adams, J L, Flowers, O M, Colvin, G, Manikumar, M, Wani, M E, Wall, G, Kohlhagen, Y, Pommier

Publikováno v: Molecular cancer therapeutics. 1(1)

Depletion of glutathione (GSH) in MCF-7 and MDA-MB-231 cell lines by pretreatment with the GSH synthesis inhibitor buthionine sulfoximine potentiated the activity of 10,11-methylenedioxy-20(S)-camptothecin, SN-38 [7-ethyl-10-hydroxy-20(S)-camptotheci

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::e022dbbc24522a2314206ecf142f4de5
https://pubmed.ncbi.nlm.nih.gov/12467234

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