Výsledky vyhledávání - "M S, Iordanov"

Molecular determinants of apoptosis induced by the cytotoxic ribonuclease onconase: evidence for cytotoxic mechanisms different from inhibition of protein synthesis

Autor: M S, Iordanov, O P, Ryabinina, J, Wong, T H, Dinh, D L, Newton, S M, Rybak, B E, Magun

Publikováno v: Cancer research. 60(7)

Cytotoxic endoribonucleases (RNases) possess a potential for use in cancer therapy. However, the molecular determinants of RNase-induced cell death are not well understood. In this work, we identify such determinants of the cytotoxicity induced by on

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::12ee7657dfd5d543a632319729db7dfa
https://pubmed.ncbi.nlm.nih.gov/10766189

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Loss of cellular K+ mimics ribotoxic stress. Inhibition of protein synthesis and activation of the stress kinases SEK1/MKK4, stress-activated protein kinase/c-Jun NH2-terminal kinase 1, and p38/HOG1 by palytoxin

Autor: M S, Iordanov, B E, Magun

Publikováno v: The Journal of biological chemistry. 273(6)

The tumor promoter palytoxin has been found to activate the stress-activated protein kinase/c-Jun NH2-terminal kinase 1 (SAPK/JNK1), and it also potentiates, as demonstrated here, the p38/HOG1 mitogen-activated protein kinase and the upstream activat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::6cbd9d16ae43e5a53fb6a286724a1636
https://pubmed.ncbi.nlm.nih.gov/9452478

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