Výsledky vyhledávání - "M S, Barnette"

Change in Intracellular Cyclic Nucleotide Content Accompanies Relaxation of the Isolated Canine Internal Anal Sphincter

Autor: M Grous, Alan F. Joslyn, M S Barnette, Winston Thompson

Publikováno v: Neurogastroenterology & Motility. 3:46-52

Changes in cyclic nucleotide content arc associated with relaxation of lower esophageal sphincter (LES) smooth muscle. Although agents that increase cyclic AMP (cAMP) or cyclic CMP (cGMP) can relax the LES, relaxation produced by activation of enteri

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::91fba9d896d793a19dc7d23af064c97f
https://doi.org/10.1111/j.1365-2982.1991.tb00046.x

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Cyclic Nucleotides Increase During Neuronally Induced Relaxation of Sphincteric and Nonsphincteric Gastrointestinal Smooth Muscle

Autor: M Grous, M S Barnette, W. J. Price, W. E. Thompson, M. Fudge, F. C. Barone, A. F. Joslyn, H. S. Ormsbee, C. D. Manning

Publikováno v: Neurogastroenterology & Motility. 2:65-72

Neuronal stimulation of most isolated precontracted gastrointestinal smooth muscle results in relaxation. This study examined the changes in cyclic nucleotide content associated with neuronally induced relaxation in sphincteric and nonsphincteric smo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a3434166dc7b473aa3c03315795e2798
https://doi.org/10.1111/j.1365-2982.1990.tb00010.x

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Association of the anti-inflammatory activity of phosphodiesterase 4 (PDE4) inhibitors with either inhibition of PDE4 catalytic activity or competition for [3H]rolipram binding

Autor: Rush Ja, Esser Km, L. B. Cieslinski, M S Barnette, T J Torphy, Burman M, Siegfried B. Christensen, Prabhakar Us, Bartus Jo

Publikováno v: Biochemical Pharmacology. 51:949-956

Phosphodiesterase 4 (PDE4) inhibitors are novel anti-inflammatory compounds. Unfortunately, the archetypal PDE4 inhibitor rolipram produces central nervous system and gastrointestinal side-effects. To exploit these agents, we need to identify PDE4 in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c2dd37212797c4643cdca190be92a344
https://doi.org/10.1016/0006-2952(96)00053-6

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Characterization of the antigen-induced contraction of colonic smooth muscle from sensitized guinea pigs

Autor: M. Grous, M. S. Barnette

Publikováno v: American Journal of Physiology-Gastrointestinal and Liver Physiology. 262:G144-G149

To study the potential of inflammatory mediators to alter colonic motility, we characterized the response of distal colonic smooth muscle to antigen challenge. Addition of ovalbumin to isolated segments of circular smooth muscle obtained from sensiti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3683b2fe84af960f34ba8afbce853267
https://doi.org/10.1152/ajpgi.1992.262.1.g144

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Human lower oesophageal sphincter relaxation is associated with raised cyclic nucleotide content

Autor: Philip J. Fowler, W. J. Price, M Grous, M S Barnette, F. C. Barone, H.S. Ormsbee

Publikováno v: Gut. 32:4-9

Increases in cyclic adenosine monophosphate and cyclic guanosine monophosphate content accompany relaxation of isolated strips of opossum and canine lower oesophageal sphincter muscle. The aim of this investigation was to characterise these responses

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc37d9ec0511fa1ca52c95d25a7c4ac9
https://doi.org/10.1136/gut.32.1.4

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Dimethylphenylpiperazinium(DMPP)-induced relaxation and elevation of cyclic GMP content in canine lower esophageal sphincter (LES)

Autor: M Grous, M S Barnette, H.S. Ormsbee

Publikováno v: Biochemical Pharmacology. 40:1757-1762

Cyclic GMP has been proposed as an intracellular mediator of neuronally-induced relaxation in lower esophageal sphincter (LES) smooth muscle. If cyclic GMP is indeed an intracellular messenger, then agents that activate enteric neurons of the sphinct

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::576c6b7887244abd55501d2ec296e2fd
https://doi.org/10.1016/0006-2952(90)90352-l

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Suppression of human inflammatory cell function by subtype-selective PDE4 inhibitors correlates with inhibition of PDE4A and PDE4B

Autor: C D, Manning, M, Burman, S B, Christensen, L B, Cieslinski, D M, Essayan, M, Grous, T J, Torphy, M S, Barnette

Publikováno v: British journal of pharmacology. 128(7)

1. Of the four major phosphodiesterase 4 (PDE4) subtypes, PDE4A, PDE4B and PDE4D are widely expressed in human inflammatory cells, including monocytes and T lymphocytes. We explored the functional role of these subtypes using ten subtype-selective PD

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::1c69566b42dceab27980c7f852f155e0
https://pubmed.ncbi.nlm.nih.gov/10602317

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SB 207499 (Ariflo), a potent and selective second-generation phosphodiesterase 4 inhibitor: in vitro anti-inflammatory actions

Autor: M S, Barnette, S B, Christensen, D M, Essayan, M, Grous, U, Prabhakar, J A, Rush, A, Kagey-Sobotka, T J, Torphy

Publikováno v: The Journal of pharmacology and experimental therapeutics. 284(1)

First-generation phosphodiesterase 4 (PDE4) inhibitors, such as rolipram, inhibit the activation of immune and inflammatory cells. The clinical use of these compounds is limited by gastrointestinal side effects, such as increased acid secretion and n

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::0036876e93af76566bd34c5456fe43e7
https://pubmed.ncbi.nlm.nih.gov/9435206

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