Zobrazeno 1 - 10 of 55 pro vyhledávání: '"M S, Anwer"'
1
cAMP-guanine exchange factor protection from bile acid-induced hepatocyte apoptosis involves glycogen synthase kinase regulation of c-Jun NH2-terminal kinase
Autor: Cynthia R. L. Webster, M. S. Anwer, K. Ponzetti, Andrea N. Johnston
Publikováno v: American Journal of Physiology-Gastrointestinal and Liver Physiology. 301:G385-G400
Cholestatic liver disorders are accompanied by the hepatic accumulation of cytotoxic bile acids that induce cell death. Increases in cAMP protect hepatocytes from bile acid-induced apoptosis by a cAMP-guanine exchange factor (cAMP-GEF)/phosphoinositi
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a96575d7f549330946eca032447460ba
https://doi.org/10.1152/ajpgi.00430.2010
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2
INTRACELLULAR SIGNALING BY BILE ACIDS
Autor: M. S. Anwer
Publikováno v: Journal of bio-science. 20
Bile acids, synthesized from cholesterol, are known to produce beneficial as well as toxic effects in the liver. The beneficial effects include choleresis, immunomodulation, cell survival, while the toxic effects include cholestasis, apoptosis and ce
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::355f1d38eecaf1c0dacecfb664caff6d
https://pubmed.ncbi.nlm.nih.gov/25378891
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3
Sodium taurocholate cotransporting polypeptide is a serine, threonine phosphoprotein and is dephosphorylated by cyclic adenosine monophosphate
Autor: Frederick J. Suchy, M. S. Anwer, Meenakshisundaram Ananthanarayanan, Bruno Stieger, Peter J. Meier, Sunil Mukhopadhyay
Publikováno v: Hepatology. 28:1629-1636
Na+/taurocholate (Na+/TC) cotransport in hepatocytes is mediated primarily by Na+/TC cotransporting polypeptide (Ntcp), and cyclic adenosine monophosphate (cAMP) stimulates Na+/TC cotransport by inducing translocation of Ntcp to the plasma membrane.
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1fea9383501054737a8d3eef95c69594
https://doi.org/10.1002/hep.510280624
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5
Veterinary Research Manpower Development for Defense
Autor: M S Anwer
The long-term goal of this training program is to increase veterinary research manpower by providing research training to veterinary students. The program is expected to develop a pipeline of research-ready veterinarians to solve biodefense and publi
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f01948ad6cec4131c3320a196a4e07ff
https://doi.org/10.21236/ada584904
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6
Mechanism of activation of the NA+/H+ exchanger by arginine vasopressin in hepatocytes
Autor: M. S. Anwer
Publikováno v: Hepatology. 20:1309-1317
Arginine vasopressin has been shown to activate the Na+/H+ exchanger in hepatocytes by calcium/calmodulin-dependent processes. Whether this activation also involves protein kinase C and is associated with changes in the intracellular pH setpoint was
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::49b679c12f4c006b1289a1bd68e61989
https://doi.org/10.1002/hep.1840200531
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7
Role of intracellular calcium and protein kinases in the activation of hepatic Na+/taurocholate cotransport by cyclic AMP
Autor: Larry R. Engelking, S. Grüne, M. S. Anwer
Publikováno v: Journal of Biological Chemistry. 268:17734-17741
Glucagon and dibutyryl cyclic AMP (Bt2cAMP) stimulate Na+/taurocholate (TC) cotransport and increase the intracellular Ca2+ concentration ([Ca2+]i) of hepatocytes. Whether the effect of cAMP is mediated via increases in [Ca2+]i, cAMP-dependent protei
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1cfebfde5436ae588c92e9685a733a86
https://doi.org/10.1016/s0021-9258(17)46766-4
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8
Amiloride and taurine inhibit cholate-induced HCO3(-)-rich choleresis in perfused rat livers
Autor: P. Zimniak, M. S. Anwer, J. M. Atkinson
Publikováno v: American Journal of Physiology-Gastrointestinal and Liver Physiology. 259:G453-G461
Bile acid-induced HCO3(-)-rich choleresis may be due to primary activation of sinusoidal Na(+)-H+ exchange or to biliary reabsorption of unconjugated bile acid. To test these hypotheses, we studied the effect of cholate and taurocholate (TC) (infused
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9293994804d489de4cbca8404a3e0c9f
https://doi.org/10.1152/ajpgi.1990.259.3.g453
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9
Cocaine and Lidocaine Interfere with Epinephrine-Induced Changes in Intracellular Calcium Concentration and Glucose Efflux from Rat Hepatocytes
Autor: Louis Shuster, McConnell J, Larry R. Engelking, Sullivan D, M. S. Anwer
Publikováno v: Pharmacology. 40:129-136
The mechanism of cocaine-induced hepatotoxicity is not clearly understood. Recent studies show that fluctuations in intracellular Ca2+ ([Ca2+]i) and/or cyclic-AMP ([cAMP]) concentration play a major role in hormone action, and sustained elevations in
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c4235ea6b388e2bbff77e1eb590f6c1
https://doi.org/10.1159/000138651
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