Zobrazeno 1 - 10
of 74
pro vyhledávání: '"M Ruhul Abid"'
Autor:
Dwight D Harris, Sharif A Sabe, Mark Broadwin, Chris Stone, Krishna Bellam, Akshay Malhotra, M Ruhul Abid, Frank W Sellke
Publikováno v:
PLoS ONE, Vol 19, Iss 7, p e0307922 (2024)
Although both clinical data and animal models suggest cardiovascular benefits following administration of Dipeptidyl Peptidase 4 (DPP-4) inhibitors, the underlying mechanisms remain unclear. We therefore sought to evaluate the effect of the DPP-4 inh
Externí odkaz:
https://doaj.org/article/96ce12eebdda43b0b8f06562ba6566f8
Autor:
Laura A Scrimgeour, Brittany A Potz, Ahmad Aboul Gheit, Yuhong Liu, Guangbin Shi, Melissa Pfeiffer, Bonnie J Colantuono, Neel R Sodha, M Ruhul Abid, Frank W Sellke
Publikováno v:
PLoS ONE, Vol 15, Iss 9, p e0238879 (2020)
BackgroundMesenchymal stem cell-derived extracellular vesicles (EVs) appear to be a very exciting treatment option for heart disease. Here, we used a swine model of chronic myocardial ischemia to evaluate the efficacy of a less-invasive method of inj
Externí odkaz:
https://doaj.org/article/d7316af8d4e045299e7d9dd2f3b8d8ad
Autor:
Sharif A. Sabe, Cynthia M. Xu, Mohamed Sabra, Dwight Douglas Harris, Akshay Malhotra, Ahmed Aboulgheit, Madigan Stanley, M. Ruhul Abid, Frank W. Sellke
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 12, Iss 1 (2023)
Background Sodium‐glucose cotransporter‐2 inhibitors are cardioprotective independent of glucose control, as demonstrated in animal models of acute myocardial ischemia and clinical trials. The functional and molecular mechanisms of these benefits
Externí odkaz:
https://doaj.org/article/57ce511c7c794b28b88ed7df1410e55d
Publikováno v:
STAR Protocols, Vol 2, Iss 3, Pp 100753- (2021)
Summary: Reactive oxygen species (ROS) are implicated in endothelial dysfunction and cardiovascular disease. Endothelial cells (ECs) produce most ATP through glycolysis rather than oxidative phosphorylation; thus mitochondrial ROS production is lower
Externí odkaz:
https://doaj.org/article/b4a0016b3f0e40698d0a977757734a4e
Autor:
Sharif A. Sabe, Laura A. Scrimgeour, Catherine Karbasiafshar, Mohamed Sabra, Cynthia M. Xu, Ahmed Aboulgheit, M. Ruhul Abid, Frank W. Sellke
Publikováno v:
The Journal of Thoracic and Cardiovascular Surgery. 165:e225-e236
Extracellular vesicle (EV) therapy has been shown to mitigate inflammation in animal models of acute myocardial ischemia/reperfusion. This study evaluates the effect of EV therapy on inflammatory signaling in a porcine model of chronic myocardial isc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac43b5c922563f13ee06b680c6eb5694
https://doi.org/10.1016/j.jtcvs.2022.07.016
https://doi.org/10.1016/j.jtcvs.2022.07.016
Autor:
Ahmed Aboulgheit, Brittany A. Potz, Laura A. Scrimgeour, Catherine Karbasiafshar, Guangbin Shi, Zhiqi Zhang, Jason T. Machan, Christoph Schorl, Alexander S. Brodsky, Karla Braga, Melissa Pfeiffer, May Gao, Olivia Cummings, Neel R. Sodha, M. Ruhul Abid, Frank W. Sellke
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 10, Iss 4 (2021)
Background Mesenchymal stem cell–derived extracellular vesicles (EVs) promote angiogenesis in the ischemic myocardium. This study examines the difference in vascular density, myocardial perfusion, molecular signaling, and gene expression between no
Externí odkaz:
https://doaj.org/article/112c3739ade342bca2aa079ba4a12cce
Publikováno v:
Frontiers in Chemistry, Vol 8 (2020)
Cardiovascular disease (CVD) has been the leading cause of death for many decades, highlighting the importance of new research and treatments in the field. The role of hypoxia and subsequent free radical production [reactive oxygen species (ROS)] hav
Externí odkaz:
https://doaj.org/article/eb1b591a5bb547e0b150200b994ec536
Autor:
Laura A. Scrimgeour, Brittany A. Potz, Ahmad Aboul Gheit, Guangbin Shi, Melissa Stanley, Zhiqi Zhang, Neel R. Sodha, Nagib Ahsan, M. Ruhul Abid, Frank W. Sellke
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 8, Iss 15 (2019)
Background Ischemic heart disease continues to be a leading cause of mortality in patients. Extracellular vesicles (EVs) provide a potential for treatment that may induce collateral vessel growth to increase myocardial perfusion. Methods and Results
Externí odkaz:
https://doaj.org/article/d554ec3170df416e8fca655c1a775ba2
Autor:
Cynthia M. Xu, Sharif A. Sabe, Rayane Brinck‐Teixeira, Mohamed Sabra, Frank W. Sellke, M. Ruhul Abid
Publikováno v:
Physiological Reports. 11
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fc2c1aa887ecbea7ce15baf6f5098c3c
https://doi.org/10.14814/phy2.15568
https://doi.org/10.14814/phy2.15568
Autor:
Brittany A. Potz, Laura A. Scrimgeour, Vasile I. Pavlov, Neel R. Sodha, M. Ruhul Abid, Frank W. Sellke
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 7, Iss 12 (2018)
Background Mesenchymal stem cell–derived extracellular vesicles (EVs) are believed to be cardioprotective in myocardial infarct. The objective of this study was to examine the effects of human mesenchymal cell–derived EV injection on cardiac func
Externí odkaz:
https://doaj.org/article/68202c77a0c8435e85e899fbb43cf64f