Zobrazeno 1 - 10 of 504 pro vyhledávání: '"M Rangarajan"'
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Akademický článek
Introduction of benzyloxy pharmacophore into aryl/heteroaryl chalcone motifs as a new class of monoamine oxidase B inhibitors
Autor: Sachithra Thazhathuveedu Sudevan, Jong Min Oh, Mohamed A. Abdelgawad, Mohammed A. S. Abourehab, T. M. Rangarajan, Sunil Kumar, Iqrar Ahmad, Harun Patel, Hoon Kim, Bijo Mathew
Publikováno v: Scientific Reports, Vol 12, Iss 1, Pp 1-19 (2022)
Abstract The inhibitory action of fifteen benzyloxy ortho/para-substituted chalcones (B1-B15) was evaluated against human monoamine oxidases (hMAOs). All the molecules inhibited hMAO-B isoform more potently than hMAO-A. Furthermore, the majority of t
Externí odkaz: https://doaj.org/article/a2bfe60187b04ffe9e2cd48d14cd228e
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Two dimensional-QSAR and molecular dynamics studies of a selected class of aldoxime- and hydroxy-functionalized chalcones as monoamine oxidase-B inhibitors
Autor: Bijo Mathew, Veerasamy Ravichandran, Seenivasan Raghuraman, T. M. Rangarajan, Mohamed A. Abdelgawad, Iqrar Ahmad, Harun M. Patel, Hoon Kim
Publikováno v: Journal of Biomolecular Structure and Dynamics. :1-11
Candidates generated from unsaturated ketone (chalcone) demonstrated as strong, reversible and specific monoamine oxidase-B (MAO-B) inhibitory activity. For the research on MAO-B inhibition, our team has synthesized and evaluated a panel of aldoxime-
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1576878d5db87ad0b078877437bf7c8b
https://doi.org/10.1080/07391102.2022.2146198
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9
Akademický článek
Replacement of Chalcone-Ethers with Chalcone-Thioethers as Potent and Highly Selective Monoamine Oxidase-B Inhibitors and Their Protein-Ligand Interactions
Autor: Bijo Mathew, Jong Min Oh, Ahmed Khames, Mohamed A. Abdelgawad, T. M. Rangarajan, Lekshmi R. Nath, Clement Agoni, Mahmoud E. S. Soliman, Githa Elizabeth Mathew, Hoon Kim
Publikováno v: Pharmaceuticals, Vol 14, Iss 11, p 1148 (2021)
To develop new potent and highly selective MAO-B inhibitors from chalcone-thioethers, eleven chalcones-thioethers were synthesized and their monoamine oxidase (MAO) inhibition, kinetics, reversibility, and cytotoxicity of lead compounds were analyzed
Externí odkaz: https://doaj.org/article/dd6eb7ca415747acbb527b53f6944a97
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