Zobrazeno 1 - 10
of 12
pro vyhledávání: '"M R. Sayen"'
Autor:
Jing Wei, Roberta A. Gottlieb, M. R. Sayen, Wenqiong J. Chen, Joshua J. Martindale, Jason A. Wall, Peter J. Belmont, Wen Yu, Jun Sun, Åsa B. Gustafsson, Christopher C. Glembotski, Paul Oeller, Mimi Ly, Diem Tran, Steve Briggs
Publikováno v:
American Journal of Physiology-Heart and Circulatory Physiology. 291:H2462-H2472
Ischemia-reperfusion (I/R) has critical consequences in the heart. Recent studies on the functions of I/R-activated kinases, such as p38 mitogen-activated protein kinase (MAPK), showed that I/R injury is reduced in the hearts of transgenic mice that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b5fdf0c5cc35aed32f0af703c1395da3
https://doi.org/10.1152/ajpheart.01311.2005
https://doi.org/10.1152/ajpheart.01311.2005
Publikováno v:
American Journal of Physiology-Cell Physiology. 284:C562-C570
Introduction of the constitutively active calcineurin gene into neonatal rat cardiomyocytes by adenovirus resulted in decreased mitochondrial membrane potential ( P < 0.05). Infection of H9c2 cells with calcineurin adenovirus resulted in increased su
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cafad19863198a4768e8fc22bee7bed3
https://doi.org/10.1152/ajpcell.00336.2002
https://doi.org/10.1152/ajpcell.00336.2002
Autor:
Derek M. Yellon, Wolfgang H. Dillmann, Shun-Hua Chi, Ruben Mestril, M. R. Sayen, Michael S. Marber
Publikováno v:
Journal of Clinical Investigation. 95:1446-1456
Myocardial protection and changes in gene expression follow whole body heat stress. Circumstantial evidence suggests that an inducible 70-kD heat shock protein (hsp70i), increased markedly by whole body heat stress, contributes to the protection. Tra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f2253a315141969250c45043c31f487
https://doi.org/10.1172/jci117815
https://doi.org/10.1172/jci117815
Publikováno v:
Scopus-Elsevier
Myocardial ischemia markedly increases the expression of several members of the stress/heat shock protein (HSP) family, especially the inducible HSP70 isoforms. Increased expression of HSP70 has been shown to exert a protective effect against a letha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f7a39afdb48b34f9c4e49f90845b4a02
https://doi.org/10.1172/jci117030
https://doi.org/10.1172/jci117030
Publikováno v:
Circulation Research. 109
Autophagy is a homeostatic response to cellular stress. It has been shown to be potently upregulated in the heart in response to a variety of interventions. However, to date, it has not been possible to monitor autophagy without sacrificing the anima
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f487a9aab8bfbe7f6ae04be029d0038f
https://doi.org/10.1161/res.109.suppl_1.ap066
https://doi.org/10.1161/res.109.suppl_1.ap066
Publikováno v:
Scopus-Elsevier
Background Mitochondria are known to be a major target during ischemic cardiac injury. Previous studies have shown that in rodent myogenic cells and in the hearts of transgenic mice in which the heat shock or stress protein 70 is increased, there is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b249d4cbc2253e445b6d7c95b4bd3e12
https://pubmed.ncbi.nlm.nih.gov/9337202
https://pubmed.ncbi.nlm.nih.gov/9337202
Autor:
Howard A. Rockman, Huaping He, Frank J. Giordano, Patrick M. McDonough, Eric Swanson, Wolfgang F. Bluhm, Wolfgang H. Dillmann, Dong-Ju Choi, M R Sayen, Randa Hilal-Dandan, Markus Meyer
The Ca2+ ATPase of the sarcoplasmic reticulum (SERCA2) plays a dominant role in lowering cytoplasmic calcium levels during cardiac relaxation and reduction of its activity has been linked to delayed diastolic relaxation in hypothyroid and failing hea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e6fe554748e80291422a9053f8a060d
https://europepmc.org/articles/PMC508201/
https://europepmc.org/articles/PMC508201/
Publikováno v:
Endocrinology. 138(1)
Thyroid hormone (T3) increases the transcription of the sarcoplasmic reticulum Ca2+ adenosine triphosphatase (ATPase) gene (SERCA 2) through three thyroid hormone response elements. The existence of repetitive cis elements with different configuratio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::9516de234b1099f9a81a168bd5500f41
https://pubmed.ncbi.nlm.nih.gov/8977381
https://pubmed.ncbi.nlm.nih.gov/8977381
Publikováno v:
The Biochemical journal.
Most of the members of the mammalian heat-shock protein (HSP) gene family have been studied and isolated from human and mouse cells. Few studies have concentrated on the HSPs of rat, a commonly used experimental animal. We have isolated and character
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c501c4e0bb62299a344aa7f45460fd6
https://pubmed.ncbi.nlm.nih.gov/8141767
https://pubmed.ncbi.nlm.nih.gov/8141767
Publikováno v:
The American journal of physiology. 261(3 Pt 1)
Decreased cardiac performance is a known complication of diabetes mellitus, but the detailed molecular mechanisms that are responsible for this contractile abnormality are only incompletely explored, and cardiac gene products of known function, which
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15df79b7536fc820d05a1a0fc39f07db
https://pubmed.ncbi.nlm.nih.gov/1887884
https://pubmed.ncbi.nlm.nih.gov/1887884