Zobrazeno 1 - 10
of 43
pro vyhledávání: '"M R Uskokovic"'
Publikováno v:
Blood. 92:2441-2449
We have studied the in vitro biological activities and mechanisms of action of 1,25-dihydroxyvitamin D3 (1,25D3) and nine potent 1,25D3 analogs on proliferation and differentiation of myeloid leukemia cell lines (HL-60, retinoic acid-resistant HL-60
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::95be5cdbee47c62dfce8ca67ba1b5f0e
https://doi.org/10.1182/blood.v92.7.2441
https://doi.org/10.1182/blood.v92.7.2441
Autor:
M R Uskokovic, AW Norman, E Elstner, H P Koeffler, T Kobayashi, M Andreeff, Reinhold Munker, W Zhang
Publikováno v:
Blood. 88:2201-2209
The active form of vitamin D3 [1 alpha, 25-dihydroxyvitamin-D3 (1 alpha, 25(OH)2D3)] modulates the proliferation and differentiation of hematopoietic cells. Analogs of 1 alpha, 25(OH)2D3 that have greater potency may have the potential as adjuvant th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a15fca4ddb613511e36d477f0b668888
https://doi.org/10.1182/blood.v88.6.2201.bloodjournal8862201
https://doi.org/10.1182/blood.v88.6.2201.bloodjournal8862201
Autor:
E A, Weinstein, D S, Rao, M L, Siu-Caldera, K Y, Tserng, M R, Uskokovic, S, Ishizuka, G S, Reddy
Publikováno v:
Biochemical pharmacology. 58(12)
1alpha,24(R)-Dihydroxyvitamin D3 [1alpha,24(R)(OH)2D3], a synthetic vitamin D3 analog, has been developed as a drug for topical use in the treatment of psoriasis. At present, the target tissue metabolism of 1alpha,24(R)(OH)2D3 is not understood compl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::ea8694033cc5f5023188bdb26aa59a70
https://pubmed.ncbi.nlm.nih.gov/10591152
https://pubmed.ncbi.nlm.nih.gov/10591152
Autor:
H, Hofer, G m, Ho, M, Peterlik, M R, Uskokovic, J K, Lee, M C, White, G H, Posner, H S, Cross
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 291(2)
1alpha,25-dihydroxyvitamin D(3) and two synthetic analogs, 1alpha, 25-dihydroxy-16-ene-23-yne-vitamin D(3) (Ro 23-7553) and 1alpha, 25-dihydroxy-16-ene-24-oxo-vitamin D(3) (JK-1624-3), were tested for their ability to specifically inhibit growth and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::76c8f0e32a480f14cdb706d8903d2015
https://pubmed.ncbi.nlm.nih.gov/10525058
https://pubmed.ncbi.nlm.nih.gov/10525058
Publikováno v:
Clinical cancer research : an official journal of the American Association for Cancer Research. 3(8)
Numerous studies have indicated that the secosteroid hormone 1alpha, 25-dihydroxyvitamin D3 protects against the development of clinical prostate cancer (PC). Whether this hormone also has therapeutic potential for patients with advanced PC has not y
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::2b7381bcc61db74e4c1081c638b81703
https://pubmed.ncbi.nlm.nih.gov/9815816
https://pubmed.ncbi.nlm.nih.gov/9815816
Publikováno v:
Journal of cellular biochemistry. 63(4)
Numerous vitamin D3 analogs (VDAs) can inhibit the proliferation of cells from several types of human malignancies. The physiologically active form of vitamin D3, 1,25-dihydroxyvitamin D3(1,25D3), is formed by successive hydroxylations of cholecalcif
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::c104177165481b61d73311d9806aab5a
https://pubmed.ncbi.nlm.nih.gov/8978465
https://pubmed.ncbi.nlm.nih.gov/8978465
Publikováno v:
Research communications in molecular pathology and pharmacology. 88(1)
Several investigators are developing calcitriol (DHCC, Compound A) derivatives which have less effect on mineral metabolism and are effective in causing differentiation of neoplastic cells. In the present study we investigated three new DHCC derivati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::38d257ae6706dc69964984a0a943b263
https://pubmed.ncbi.nlm.nih.gov/7620840
https://pubmed.ncbi.nlm.nih.gov/7620840
Publikováno v:
Leukemia. 8(12)
All-trans retinoic acid (ATRA) has been demonstrated to induce the in vitro differentiation of human myeloid leukemic cells by several investigators. In addition, ATRA has been reported to induce complete remission in patients with acute promyelocyti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::bdcb2d715d32e54f411c1399001efbba
https://pubmed.ncbi.nlm.nih.gov/7528858
https://pubmed.ncbi.nlm.nih.gov/7528858
Autor:
M, Shabahang, R R, Buras, F, Davoodi, L M, Schumaker, R J, Nauta, M R, Uskokovic, R V, Brenner, S R, Evans
Publikováno v:
Cancer research. 54(15)
The use of 1,25-dihydroxyvitamin D3 as an antiproliferative agent in the treatment of cancer is limited by its hypercalcemic effects. Analogues with equivalent or greater antiproliferative activities but smaller hypercalcemic effects have been develo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::2998f9401681be579ae6d78a2a3eb028
https://pubmed.ncbi.nlm.nih.gov/8033137
https://pubmed.ncbi.nlm.nih.gov/8033137