Zobrazeno 1 - 10 of 60 pro vyhledávání: '"M R Robinson"'
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Akademický článek
Lateral gain is impaired in macular degeneration and can be targeted to restore vision in mice
Autor: M. Rizzi, K. Powell, M. R. Robinson, T. Matsuki, J. Hoke, R. N. Maswood, A. Georgiadis, M. Georgiou, P. R. Jones, C. Ripamonti, F. M. Nadal-Nicolás, M. Michaelides, G. S. Rubin, A. J. Smith, R. R. Ali
Publikováno v: Nature Communications, Vol 13, Iss 1, Pp 1-10 (2022)
Treatments to rescue vision are currently limited. Here, the authors identify a cone-driven gain control mechanism that reduces visual function beyond the atrophic area in humans. They also show that activating laterally projecting cells results impr
Externí odkaz: https://doaj.org/article/e63d1cf87c5a40a4bace2190d44234ce
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2
Akademický článek
Polθ inhibitors elicit BRCA-gene synthetic lethality and target PARP inhibitor resistance
Autor: Diana Zatreanu, Helen M. R. Robinson, Omar Alkhatib, Marie Boursier, Harry Finch, Lerin Geo, Diego Grande, Vera Grinkevich, Robert A. Heald, Sophie Langdon, Jayesh Majithiya, Claire McWhirter, Niall M. B. Martin, Shaun Moore, Joana Neves, Eeson Rajendra, Marco Ranzani, Theresia Schaedler, Martin Stockley, Kimberley Wiggins, Rachel Brough, Sandhya Sridhar, Aditi Gulati, Nan Shao, Luned M. Badder, Daniela Novo, Eleanor G. Knight, Rebecca Marlow, Syed Haider, Elsa Callen, Graeme Hewitt, Joost Schimmel, Remko Prevo, Christina Alli, Amanda Ferdinand, Cameron Bell, Peter Blencowe, Chris Bot, Mathew Calder, Mark Charles, Jayne Curry, Tennyson Ekwuru, Katherine Ewings, Wojciech Krajewski, Ellen MacDonald, Hollie McCarron, Leon Pang, Chris Pedder, Laurent Rigoreau, Martin Swarbrick, Ed Wheatley, Simon Willis, Ai Ching Wong, Andre Nussenzweig, Marcel Tijsterman, Andrew Tutt, Simon J. Boulton, Geoff S. Higgins, Stephen J. Pettitt, Graeme C. M. Smith, Christopher J. Lord
Publikováno v: Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Polθ has been recently identified as a therapeutic target in cancer but specific inhibitors are currently unavailable. Here, the authors identify small molecule inhibitors of Polθ’s polymerase activity which elicit BRCA1/2 synthetic lethality, en
Externí odkaz: https://doaj.org/article/a5462d8522964b13a5f79a9e1b35250a
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4
Pol theta inhibitors elicit BRCA-gene synthetic lethality and target PARP inhibitor resistance
Autor: Christina Alli, Christopher J. Lord, Marcel Tijsterman, Katherine Ewings, Marco Ranzani, Ai Ching Wong, Claire McWhirter, Martin Swarbrick, Harry Finch, Robert A. Heald, Rachel Brough, Nan Shao, Rebecca Marlow, Shaun Moore, Vera Grinkevich, Ellen Macdonald, Jayne Curry, Helen M. R. Robinson, Graeme Hewitt, Eleanor Knight, Christopher Bot, Syed Haider, Mathew Calder, Theresia A. Schaedler, Hollie McCarron, Luned M. Badder, Aditi Gulati, Martin Stockley, Eeson Rajendra, Sophie Langdon, Stephen J. Pettitt, Simon J. Boulton, Chris Pedder, Elsa Callen, Ed Wheatley, Wojciech Krajewski, André Nussenzweig, Daniela Novo, Peter Blencowe, Jayesh B. Majithiya, Laurent Rigoreau, Lerin Geo, Cameron Bell, Kimberley A. Wiggins, Diana Zatreanu, Geoff S. Higgins, Remko Prevo, Tennyson Ekwuru, Leon Pang, Simon N. Willis, Sandhya Sridhar, Marie Boursier, Diego Grande, Joana F. Neves, Mark Charles, Joost Schimmel, Andrew Tutt, Niall M. B. Martin, Omar Alkhatib, Amanda Ferdinand, Graeme C. M. Smith
Publikováno v: Nature Communications, 12(1). NATURE RESEARCH
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Nature Communications
To identify approaches to target DNA repair vulnerabilities in cancer, we discovered nanomolar potent, selective, low molecular weight (MW), allosteric inhibitors of the polymerase function of DNA polymerase Polθ, including ART558. ART558 inhibits t
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e50fa596497393cd588028cd95531690
https://hdl.handle.net/1887/3213877
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7
Table S3. Diversity of the 20 microsatellite loci. from Major histocompatibility complex-linked social signalling affects female fertility
Autor: D. Burger, S. Thomas, H. Aepli, M. Dreyer, G. Fabre, E. Marti, H. Sieme, M. R. Robinson, C. Wedekind
Observed (Hobs) and expected (Hexp) heterozygosity, test for deviation from Hardy-Weinberg equilibrium (2, d.f., p), heterozygosity deficiency coefficient (Fis), and differentiation between Warmblood and Franches-Montagnes horses (Fst).
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b0ea5fd930a7d59ea05f557d55337ed
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9
Table S4. Effects of genetic similarity on female fertility (pregnant yes/no) based on numbers of shared MHC antigens instead of the dichotomous sharing/no sharing. from Major histocompatibility complex-linked social signalling affects female fertility
Autor: D. Burger, S. Thomas, H. Aepli, M. Dreyer, G. Fabre, E. Marti, H. Sieme, M. R. Robinson, C. Wedekind
Likelihood ratio tests comparing GLMMs and GLMs with genetic markers (fixed factors) and/or stallion identity (“ID”, random factor) and reference models (indicated in italics) to test the effects of (A) number of shared MHC antigens (“MHC”, r
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::71751a742f06c069e4103801e275f3db
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10
Table S1. The 20 microsatellite markers used to determine overall genetic similarity from Major histocompatibility complex-linked social signalling affects female fertility
Autor: D. Burger, S. Thomas, H. Aepli, M. Dreyer, G. Fabre, E. Marti, H. Sieme, M. R. Robinson, C. Wedekind
The name of the markers, their chromosomal location, their primer sequences [38], the annealing temperature, and the fluorophores we used, the number of alleles found in the present sample (N = 148), and the number of alleles previously observed in 3
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::83f1a2b7a716c18835e7b90ad626a5b8
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