Zobrazeno 1 - 10
of 47
pro vyhledávání: '"M R Crompton"'
Publikováno v:
British Journal of Cancer
Interferon-gamma (IFN-gamma) has some anti-tumour activity in human ovarian cancer. This cytokine inhibited proliferation in three of four ovarian cancer cell lines in vitro. We then compared the action of IFN-gamma in two cell lines, one sensitive a
Autor:
Karen Barker, M. R. Crompton
Publikováno v:
British Journal of Cancer
Activating ras mutations are found in many types of human tumour. Mutations in Harvey (H-), Kirsten (K-) and neuronal (N-) ras are, however, rarely found in breast carcinomas. TC21 is a ras family member that shares close homology to H-, K- and N-ras
Autor:
M. R. Crompton, Cornelius Katona, Christine Bowden, Sandra Lowther, Sharon C. Cheetham, Roger W. Horton
Publikováno v:
European Neuropsychopharmacology. 7:247-252
We have quantitated dopamine uptake sites, labelled with [3H]GBR12935, in caudate, putamen and nucleus accumbens of suicides with a retrospective diagnosis of depression, and age and gender-matched controls. Suicides were subdivided into those who ha
Autor:
G Harold, R Knox, Barry A. Gusterson, M R Crompton, Fiona E. Yull, C Neil, S Hobbs, Wei Cui, M Iwobi, Beatrice A. Howard, T Kamalati, Anthony John Clark
Publikováno v:
Endocrine Related Cancer. 4:67-74
Publikováno v:
Pharmacology & Toxicology. 71:86-95
beta-Adrenoceptors were measured by saturation binding of 3H.CGP 12177 in nine brain regions and pineal from suicides, with a firm retrospective diagnosis of depression, and age and sex matched controls. Twenty one suicides had not recently received
Publikováno v:
Clinicalexperimental metastasis. 16(5)
The proliferation of eukaryotic cells is primarily regulated by a decision made during the G1 phase of the cell cycle as to remain in the cycle and divide, or to withdraw from the cycle and adopt a different cell fate. During this time, environmental
Autor:
D, Bertwistle, S, Swift, N J, Marston, L E, Jackson, S, Crossland, M R, Crompton, C J, Marshall, A, Ashworth
Publikováno v:
Cancer research. 57(24)
Women carrying a germ-line mutation in the BRCA1 or BRCA2 genes have a high risk of developing breast cancer, and loss of the wild-type allele in tumors suggests that these genes function as tumor suppressor genes. The BRCA2 gene encodes a 3418-amino
Publikováno v:
Psychopharmacology. 134(2)
Corticotropin-releasing factor (CRF) receptors were measured by saturation binding in frontal and motor cortex of suicides with a firm retrospective diagnosis of depression, and matched controls. The suicides were divided into those who were free of
Publikováno v:
Molecular psychiatry. 2(4)
5-HT1D and 5-HT1E/1F receptor binding sites were measured in brain samples obtained at postmortem from suicide victims with a firm retrospective diagnosis of depression, and matched controls. In antidepressant-free suicides a significantly higher num
Autor:
S Hobbs, Fiona E. Yull, R Knox, G Harold, C Neil, Barry A. Gusterson, Wei Cui, M R Crompton, M Iwobi, Tahereh Kamalati, Anthony John Clark
Publikováno v:
Gene therapy. 4(2)
The gene encoding E. coli nitroreductase (NTR) was expressed in the luminal cells of the mammary gland of transgenic mice using the ovine beta-lactoglobulin promoter. Treatment of NTR expressing animals with the prodrug CB1954 (5-aziridin-1-yl-2-4-di