Human myelomeningocele risk and ultra-rare deleterious variants in genes associated with cilium, WNT-signaling, ECM, cytoskeleton and cell migration

Autor: K. S. Au, L. Hebert, P. Hillman, C. Baker, M. R. Brown, D.-K. Kim, K. Soldano, M. Garrett, A. Ashley-Koch, S. Lee, J. Gleeson, J. E. Hixson, A. C. Morrison, H. Northrup

Publikováno v: Scientific Reports, Vol 11, Iss 1, Pp 1-21 (2021)

Abstract Myelomeningocele (MMC) affects one in 1000 newborns annually worldwide and each surviving child faces tremendous lifetime medical and caregiving burdens. Both genetic and environmental factors contribute to disease risk but the mechanism is

Externí odkaz: https://doaj.org/article/d4a42c6c5b2a44348b13fe3b51742226

Path tortuosity changes the transport cost paradigm in terrestrial animals

Autor: Kelly A. Mackintosh, Mathieu Garel, Richard Gunner, J. Miloš, Richard S. Metcalfe, Rory P. Wilson, Pascal Marchand, M. R. Brown, Nigel C. Bennett, Anne Loison, Václav Silovský, Michael S. Painter, Luca Börger, David M. Scantlebury, Kayleigh A. R. Rose, James Redcliffe, Nikki J. Marks, Melitta A. McNarry, Mark D. Holton, Carole Toïgo

Publikováno v: Wilson, R, Rose, K, Metcalfe, R, Holton, M D, Redcliffe, J, Gunner, R, Börger, L, Loison, A, Jezek, M, Painter, M S, Silovsky, V, Marks, N, Garel, M, Toïgo, C, Marchand, P, Bennett, N C, McNarry, M A, Mackintosh, K A, Brown, M R & Scantlebury, D M 2021, ' Path tortuosity changes the transport cost paradigm in terrestrial animals ', Ecography, vol. 44, no. 10, pp. 1524-1532 . https://doi.org/10.1111/ecog.05850

The time that animals spend travelling at various speeds and the tortuosity of their movement paths are two of the many things that affect space-use by animals. In this, high turn rates are predicted to be energetically costly, especially at high tra

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9db116421a5f89ade3bd20e14ef0b588
https://doi.org/10.1111/ecog.05850

Detection of urethane-induced genotoxicity in vitro using metabolically competent human 2D and 3D spheroid culture models

Autor: James A. Tonkin, Ume-Kulsoom Shah, Shareen H. Doak, M. R. Brown, Katherine E. Chapman, George E. Johnson, Eleanor C. Wilde, Gareth J.S. Jenkins, Jatin R Verma

Publikováno v: Mutagenesis. 35:445-452

In vitro genotoxicity studies are a quick and high throughput approach to assess the genotoxic potential of chemicals; however, the reliability of these tests and their relevance to in vivo effects depends on the choice of representative cell line an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b755356f16ce5a2d98c3ba5d94c14241
https://doi.org/10.1093/mutage/geaa029

Mosquito Peptide Hormones: Diversity, Production, and Function

Autor: M R, Strand, M R, Brown, K J, Vogel

Publikováno v: Advances in insect physiology. 51

Mosquitoes, like other insects, produce a diversity of peptide hormones that are processed from different precursor proteins and have a range of activities. Early studies relied on purification of bioactive peptides for hormone identification, but mo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::048367b536e57494b10fc66ca0c983e4
https://pubmed.ncbi.nlm.nih.gov/30662099

Quantification of Nanoparticle Dose and Vesicular Inheritance in Proliferating Cells

Autor: Andy Brown, Rik Brydson, Paul Rees, M. R. Brown, Huw D. Summers, Mark D. Holton, James A. Tonkin, Nicole Hondow

Publikováno v: ACS Nano

Assessing dose in nanoparticle-cell interactions is inherently difficult due to a complex multiplicity of possible mechanisms and metrics controlling particle uptake. The fundamental unit of nanoparticle dose is the number of particles internalized p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf28e540d4f9d25a1355be7af8dc58dc
https://doi.org/10.1021/nn4019619