Výsledky vyhledávání - "M R Alderson"

A metalloprotease inhibitor blocks shedding of the IL-6 receptor and the p60 TNF receptor

Autor: J Müllberg, F H Durie, C Otten-Evans, M R Alderson, S Rose-John, D Cosman, R A Black, K M Mohler

Publikováno v: The Journal of Immunology. 155:5198-5205

Many cytokines and soluble cytokine receptors are generated by limited proteolysis of membrane-bound precursors. We have examined the ability of the recently described metalloprotease inhibitor, TNF-alpha protease inhibitor (TAPI), and other protease

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6e1855bd6ab233984f25e5d9a62b7cc6
https://doi.org/10.4049/jimmunol.155.11.5198

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Recombinant CD40 ligand exerts potent biologic effects on T cells

Autor: W C Fanslow, K N Clifford, M Seaman, M R Alderson, M K Spriggs, R J Armitage, F Ramsdell

Publikováno v: The Journal of Immunology. 152:4262-4269

Murine and human CD40 ligand (CD40L) were recently cloned, expressed, and shown to possess potent activity on human and murine B cells, including stimulation of proliferation and Ig secretion in the presence of cytokines. In addition to its action on

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::42ae2eafd345d1301bbd39925f554965
https://doi.org/10.4049/jimmunol.152.9.4262

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Regulation of human monocyte cell-surface and soluble CD23 (Fc epsilon RII) by granulocyte-macrophage colony-stimulating factor and IL-3

Autor: M R Alderson, T W Tough, S F Ziegler, R J Armitage

Publikováno v: The Journal of Immunology. 149:1252-1257

We have investigated the regulation of expression of cell-surface and soluble CD23 (sCD23) by purified human peripheral blood monocytes and in cultures of human whole blood. IL-3, IL-4, and GM-CSF were found to markedly enhance the expression of CD23

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1379f86332499d713ee982e212f56d3b
https://doi.org/10.4049/jimmunol.149.4.1252

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Induction of macrophage inflammatory protein-1 beta gene expression in human monocytes by lipopolysaccharide and IL-7

Autor: S F Ziegler, T W Tough, T L Franklin, R J Armitage, M R Alderson

Publikováno v: The Journal of Immunology. 147:2234-2239

HuMIP-1 beta is a member of a gene family of inflammatory cytokines whose expression is induced by proinflammatory and mitogenic stimuli. The gene was rapidly induced in human peripheral blood monocytes by either LPS or IL-7. However, IL-7 was unable

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::cfd448642a74fec15f3795c7393b2ac6
https://doi.org/10.4049/jimmunol.147.7.2234

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Interleukin 7 enhances cytolytic T lymphocyte generation and induces lymphokine-activated killer cells from human peripheral blood

Autor: M B Widmer, M R Alderson, H M Sassenfeld

Publikováno v: The Journal of Experimental Medicine

The effects of purified recombinant interleukin 7 (IL-7) on the generation of cytolytic T lymphocytes (CTL) in mixed lymphocyte culture (MLC) and on the induction of lymphokine-activated killer (LAK) cells in autologous cultures of human peripheral b

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9700b808a2bb244c201d807434de22f2
https://doi.org/10.1084/jem.172.2.577

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Molecular cloning and immunologic reactivity of a novel low molecular mass antigen of Mycobacterium tuberculosis

Autor: R N, Coler, Y A, Skeiky, T, Vedvick, T, Bement, P, Ovendale, A, Campos-Neto, M R, Alderson, S G, Reed

Publikováno v: Journal of immunology (Baltimore, Md. : 1950). 161(5)

Polypeptide Ags present in the culture filtrate of Mycobacterium tuberculosis were purified and evaluated for their ability to stimulate PBMC from purified protein derivative (PPD)-positive healthy donors. One such Ag, which elicited strong prolifera

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::0fd4da7fba41d1a2ed0b94299eef28dc
https://pubmed.ncbi.nlm.nih.gov/9725231

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CD40 ligand is not essential for the development of cell-mediated immunity and resistance to Mycobacterium tuberculosis

Autor: A, Campos-Neto, P, Ovendale, T, Bement, T A, Koppi, W C, Fanslow, M A, Rossi, M R, Alderson

Publikováno v: Journal of immunology (Baltimore, Md. : 1950). 160(5)

It has been proposed that the induction of cellular immunity and resistance to intracellular pathogens is dependent upon CD40 ligand (CD40L). In the present study we show that this proposal is not ubiquitously supported. Mice genetically deficient in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::f070669a3aa507220108b067a10b32b4
https://pubmed.ncbi.nlm.nih.gov/9498737

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Human purified protein derivative-specific CD4+ T cells use both CD95-dependent and CD95-independent cytolytic mechanisms

Autor: D M, Lewinsohn, T T, Bement, J, Xu, D H, Lynch, K H, Grabstein, S G, Reed, M R, Alderson

Publikováno v: Journal of immunology (Baltimore, Md. : 1950). 160(5)

CTL, both CD4+ and CD8+, are essential in the eradication of intracellular pathogens. Data generated using murine T cells have suggested a critical role for CD95 (Fas, Apo-1) in CD4+ T cell-induced apoptosis of target cells. In contrast, CD8+ CTL pre

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::02b4b3df86cfd793a8262f72a4b96e3b
https://pubmed.ncbi.nlm.nih.gov/9498779

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