Zobrazeno 1 - 10
of 105
pro vyhledávání: '"M R, Spitz"'
Publikováno v:
Cancer. 112:2756-2764
BACKGROUND. The double-strand break (DSB) repair capacity has been implicated in the survival of patients in several cancer types. However, little is known about the prognostic importance of the key DSB repair genes—ataxia-telangiectasia mutated (A
Publikováno v:
British Journal of Cancer
The abnormality of DNA methylation is involved in tumour progression, and thus has a modulating effect on clinical outcome of cancer patients. In this study, we measured the mRNA expression levels of three methylation-regulating genes (DNMT1, DNMT3b,
Publikováno v:
Cancer. 107:705-711
BACKGROUND. The familial risk of bladder cancer (BC) is not well understood and, to date, little attention has been paid to the joint effect of smoking and family history in modifying the risk of BC. The authors investigated the role of family histor
Publikováno v:
Genes, brain, and behavior. 12(2)
Many studies examining genetic influences on physical activity (PA) have evaluated the impact of single nucleotide polymorphisms (SNPs) related to the development of lifestyle-related chronic diseases, under the hypothesis that they would be associat
Publikováno v:
Clinical genetics. 70(3)
Tumor recurrence is a hallmark of superficial bladder cancer. Currently, a molecular marker for bladder cancer recurrence is lacking. E-cadherin plays an important role in epithelial development and in the establishment and maintenance of cell–cell
Publikováno v:
Cancer research. 61(23)
Mounting epidemiological evidence suggests that smoking may play a role in the etiology of breast cancer. Because smoking-related DNA adducts are detectable in both normal and malignant breast tissues, we hypothesized that breast cancer patients may
Publikováno v:
Cancer research. 61(21)
Gamma-radiation results in cell cycle arrest and apoptosis in a wide variety of cells. Cell cycle arrest provides time for the cell to repair damaged DNA before entering the next phase of the cycle. If the damage is severe and cannot be repaired, the
Publikováno v:
Cancer research. 61(21)
Extracellular matrix-degrading matrix metalloproteinase-1 (MMP-1) is one of the interstitial collagenases likely to be involved in tumor invasion and metastasis. MMP-1 may also contribute to tumor initiation and development by altering the cellular m
Publikováno v:
American journal of industrial medicine. 40(5)
Epidemiologic studies often must rely upon questionnaire data to assess past exposures. The ability of questionnaires to rank migrant farmworkers according to past pesticide exposure is not known.We conducted a pilot feasibility study to measure a pa
Autor:
S M, Lippman, M R, Spitz
Publikováno v:
Journal of clinical oncology : official journal of the American Society of Clinical Oncology. 19
Lung cancer is the leading cause of cancer deaths in the United States and the world, with grim incidence and mortality figures underscoring the need for new approaches, such as chemoprevention, for controlling this disease. There have been definitiv