Zobrazeno 1 - 10
of 11
pro vyhledávání: '"M R, Prausnitz"'
Publikováno v:
Methods in molecular medicine. 37
The mechanism by which high-voltage pulses transiently disrupt lipid bilayers in cell membranes has been the subject of controversy since electroporation was first observed almost three decades ago. Determining the mechanism by which such pulses perm
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::0caa0c089184dc7fd596a877e3504e6c
https://pubmed.ncbi.nlm.nih.gov/21445737
https://pubmed.ncbi.nlm.nih.gov/21445737
Autor:
A, Edward, M R, Prausnitz
Publikováno v:
Pharmaceutical research. 18(11)
To develop a theoretical model to predict the passive, steady-state permeability of cornea and its component layers (epithelium, stroma, and endothelium) as a function of drug size and distribution coefficient (phi). The parameters of the model shoul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::91e9b84f300d086875d05cdadeeb603e
https://pubmed.ncbi.nlm.nih.gov/11758755
https://pubmed.ncbi.nlm.nih.gov/11758755
Publikováno v:
Pharmaceutical research. 18(11)
To determine the dependence on acoustic parameters of molecular uptake and viability of cells exposed to low-frequency ultrasound.DU145 prostate cancer cells bathed in a solution of calcein were exposed to ultrasound at 24 kHz over a range of differe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::cac36ea33129c4a04b1bb4d317bb7d03
https://pubmed.ncbi.nlm.nih.gov/11758757
https://pubmed.ncbi.nlm.nih.gov/11758757
Publikováno v:
Pharmaceutical research. 18(6)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::77fbec9be178a3deee8f223bf89db7e7
https://pubmed.ncbi.nlm.nih.gov/11474797
https://pubmed.ncbi.nlm.nih.gov/11474797
Publikováno v:
Journal of pharmaceutical sciences. 87(8)
Although modern biotechnology has produced extremely sophisticated and potent drugs, many of these compounds cannot be effectively delivered using current drug delivery techniques (e.g., pills and injections). Transdermal delivery is an attractive al
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::7646fdd8978dedf76a71d04da929d92c
https://pubmed.ncbi.nlm.nih.gov/9687334
https://pubmed.ncbi.nlm.nih.gov/9687334
Publikováno v:
Pharmaceutical research. 15(6)
Ultrasound has been shown to transiently permeabilize biological membranes, thereby facilitating delivery of large compounds such as proteins and DNA into cells and across tissues such as skin. In this study, we sought to quantitatively determine the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::5e9428e2b5ca93b0e20dd82b6dbf86d0
https://pubmed.ncbi.nlm.nih.gov/9647359
https://pubmed.ncbi.nlm.nih.gov/9647359
Publikováno v:
Pharmaceutical research. 14(5)
Macromolecules were investigated as chemical enhancers of transdermal transport by skin electroporation. Although unable to enhance passive or iontophoretic transport, macromolecules are proposed to enhance electroporation-assisted delivery by stabil
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::c339b00d5a1e2b33e249338fb20abfc7
https://pubmed.ncbi.nlm.nih.gov/9165536
https://pubmed.ncbi.nlm.nih.gov/9165536
Autor:
M R, Prausnitz
Publikováno v:
Critical reviews in therapeutic drug carrier systems. 14(4)
Great advances in transdermal delivery of macromolecules have been made within the last few years using ultradeformable liposomes, electroporation, and low-frequency ultrasound, each of which has been shown to deliver macromolecules at clinically use
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::b600307c7746d7415de3a0851d45fd38
https://pubmed.ncbi.nlm.nih.gov/9450177
https://pubmed.ncbi.nlm.nih.gov/9450177
Publikováno v:
Pharmaceutical research. 12(4)
A fluorescence measurement system and methods of data analysis were developed to measure rapid kinetics of transdermal transport in vitro. Three variations on the technique were demonstrated, where the receptor compartment concentration was determine
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::c2db174b9fc62689858c2ecad30a95de
https://pubmed.ncbi.nlm.nih.gov/7596990
https://pubmed.ncbi.nlm.nih.gov/7596990
Publikováno v:
Pharmaceutical research. 11(12)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::536927e2f16d34859f6b357f0bbdaabc
https://pubmed.ncbi.nlm.nih.gov/7899252
https://pubmed.ncbi.nlm.nih.gov/7899252