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Modulation of Aspirin-Insensitive Eicosanoid Biosynthesis by 6-Methylprednisolone in Unstable Angina

Autor: Paola Patrignani, Massimo Pasquale, Franco Cuccurullo, M. R. Panara, Anita Greco, A. Ganci, Domenico Di Gregorio, Andrea Mezzetti, Francesco Cipollone, Ettore Porreca

Publikováno v: Circulation. 107:55-61

Background— The evidence that inflammation plays a pivotal role in the pathophysiology of acute coronary syndromes prompted us to investigate the effects of glucocorticoid treatment on leukotriene (LT) C 4 and thromboxane (TX) A 2 biosynthesis in u

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a73da4d4433b89a63e62150f15bcb2e2
https://doi.org/10.1161/01.cir.0000043260.82447.62

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The human pharmacology of monocyte cyclooxygenase 2 inhibition by cortisol and synthetic glucocorticoids

Autor: Carlo Patrono, M. R. Panara, Paola Patrignani, Emanuela Ricciotti, Giovanna Santini, Francesca Seta, Marta L. Capone, Stefania Tacconelli, Maria G. Sciulli

Publikováno v: Clinical Pharmacology & Therapeutics. 70:415-424

Background We studied the concentration dependence of the inhibitory effects of cortisol, 6-methylprednisolone, and dexamethasone on cyclooxygenase-2 (COX-2) expression and activity in human monocytes in response to lipopolysaccharide (LPS) in vitro.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a911dc021addc63295e91778e2e2dfe
https://doi.org/10.1016/s0009-9236(01)14130-5

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Effects of nimesulide on constitutive and inducible prostanoid biosynthesis in human beings*

Autor: Annamaria Pace, Giulia Renda, Carlo Patrono, Paola Patrignani, Giovanna Santini, M. R. Panara, M. T. Rotondo, Maria G. Sciulli, Roberto Padovano

Publikováno v: Clinical Pharmacology & Therapeutics. 63:672-681

Background The aim of this study was to test the hypothesis that nimesulide, a nonsteroidal antiinflammatory drug, or its principal metabolite 4-hydroxynimesulide, is a selective inhibitor of prostaglandin H synthase-2 in human beings. Methods Hepari

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eac123d5683352e6a0b2aac6052b26d6
https://doi.org/10.1016/s0009-9236(98)90091-1

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Inhibition of Granuloma Formation Induced by Potassium Permanganate in the Mouse by a Specific Human Recombinant Receptor Antagonist for Interleukin-1 (hrIL-1ra)

Autor: Stavros Fridas, M. R. Panara, Fiore S, Marcella Reale, F. C. Placido, Renato C. Barbacane, Alfredo Grilli, Pio Conti

Publikováno v: Cellular Immunology. 147:446-457

Interleukin-1 (IL-1) is a polypeptide which mediates several systemic changes associated with infection, inflammation and injury, such as fever, neutrophilia, increased acute phase protein synthesis, and arachidonic acid metabolites. Recently, a natu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc2e7d3a5bfe9ba55e0c6f6c4743fdbc
https://doi.org/10.1006/cimm.1993.1083

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Human recombinant IL-1 receptor antagonist (IL-IRa) inhibits leukotriene B4 generation from human monocyte suspensions stimulated by lipopolysaccharide (LPS)

Autor: M. R. Panara, Roy A. Dempsey, Mauro Bongrazio, Marcella Reale, Pio Conti, Renato C. Barbacane

Publikováno v: Clinical and Experimental Immunology. 91:526-531

SUMMARYThe effect of human recombinant IL-1 receptor antagonist (hrIL-1Ra) on leukotriene B4 (LTB4) release was investigated in activated human monocyte cultures. To stimulate LTB4 generation, LPS was used as an agonist. Detection was performed with

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b814787b32ed40f8ee48fde6eff1d1cb
https://doi.org/10.1111/j.1365-2249.1993.tb05936.x

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Effect of interleukin-1 receptor antagonist on vascular smooth muscle cell proliferation

Autor: M. R. Panara, Ettore Porreca, Renato C. Barbacane, Concetta Di Febbo, Pio Conti, Franco Cuccurulloa

Publikováno v: Atherosclerosis. 99:71-78

The development of the atheromatous plaque is largely dependent on vascular smooth muscle cell proliferation and production of biologically active compounds such as cytokines and growth factors. Cytokines such as IL-1 derived from blood vessel wall m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5640a421651d83ff2b2239841c3cff90
https://doi.org/10.1016/0021-9150(93)90052-v

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Inhibition of Interleukin-1 (Alpha and Beta), Interleukin-2 Secretion and Surface Expression of Interleukin-2 Receptor (IL-2R) by a Novel Cytokine Interleukin-1 Receptor Antagonist (IL-lra)

Autor: Domenico Gambi, A. M. Porrini, Renato C. Barbacane, Roy A. Dempsey, Mauro Bongrazio, Pio Conti, Marcella Reale, M. R. Panara

Publikováno v: Scandinavian Journal of Immunology. 36:27-34

IL-1 is a mediator of the acute inflammatory response and plays a key role in influencing growth and differentiation of immunocompetent lymphocytes. It can enhance transcription and secretion of the T-cell growth factor interleukin-2 (IL-2) and can s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ddd6e7433d7339503fa30e1aad1e891e
https://doi.org/10.1111/j.1365-3083.1992.tb02937.x

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Enhancing Effect of Electromagnetic Exposure on Calciumionophore (A23187), but Not IL-1, Induced Txa2 Release by Human Neutrophils

Autor: Giovanni Gigante, F. Bersani, Marcella Reale, M. R. Panara, Pio Conti, Mauro Bongrazio, C. Franceschi, I. Caruso, Renato C. Barbacane

Publikováno v: International Journal of Immunopathology and Pharmacology. 4:55-60

The exposure of human polymorphonuclears to an extremely low frequency (3 Hz) electromagnetic field for 1 hour had an enhancing effect on thromboxane A2 release stimulated by A23187 calcium ionophore. On the contrary, IL-1 stimulation of TxA2 product

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ae888d507c4d18ee877978c8cf5dc7f2
https://doi.org/10.1177/039463209100400107

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Inhibition of leukotriene B4(LTB4) by recombinant interleukin-1 receptor antagonist (IL-1RA) on human monocytes

Autor: Renato C. Barbacane, Roy A. Dempsey, Marcella Reale, Pio Conti, M. R. Panara, Mauro Bongrazio

Publikováno v: Agents and Actions. 36:C93-C95

Macrophages are a primary source of interleukin-1 (IL-1), a glycoprotein which plays an important and essential role in the immune response and inflammation. Cytokines stimulate many different cells to produce increasing amounts of arachidonic acid m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b4278054dfab312801fb0a163326d79
https://doi.org/10.1007/bf01996107

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Effects of vitamin E supplementation on F(2)-isoprostane and thromboxane biosynthesis in healthy cigarette smokers

Autor: Giovanni Davì, Stefania Tacconelli, Andrea Mezzetti, Gabriele Bittolo Bon, Giovanni Ciabattoni, Paola Alessandrini, Giovanna Santini, Carlo Patrono, Tonino Bucciarelli, M. R. Panara, Paola Patrignani, Francesca Seta, Pietro Gallina, Francesco Cipollone, Maria G. Sciulli

Publikováno v: Circulation. 102(5)

Background —Increased formation of 8-iso-prostaglandin (PG) F 2α and thromboxane (TX) A 2 , potent agonists of platelet and vascular thromboxane (TH)/PGH 2 receptors, has been detected in cigarette smokers. We performed a randomized, double-blind,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d5aa6947c11ddc2eb2ef21332cc9eb1
https://pubmed.ncbi.nlm.nih.gov/10920066

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