Zobrazeno 1 - 8
of 8
pro vyhledávání: '"M R, Palazzolo"'
Publikováno v:
Biochemical and Biophysical Research Communications. 210:921-930
Reduced expression of calmodulin (CaM) and decreased activity of low Km cyclic AMP (cAMP) phosphodiesterase (PDE) are associated with uncontrolled diabetes. This condition can be readily mimicked in hepatocytes cultivated in insulin-depleted medium (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::71bf4b20b2186109bc3bc99779f276fe
https://doi.org/10.1006/bbrc.1995.1745
https://doi.org/10.1006/bbrc.1995.1745
Publikováno v:
Endocrinology. 138:5052-5054
Insulin positively regulates transcription of rat calmodulin (CaM) I gene and activates the low Km cyclic AMP (cAMP) phosphodiesterase (PDE). To elucidate the mechanism of transcriptional regulation, rat hepatoma (H-411E) cells were transfected with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0353d7d33e71c6702d508875fd1c8938
https://doi.org/10.1210/endo.138.11.5648
https://doi.org/10.1210/endo.138.11.5648
Publikováno v:
Proceedings of the Association of American Physicians. 109(5)
We have shown previously that insulin positively regulates transcription of the rat calmodulin (CaM) I gene. This activation occurs concomitantly with the activation of the low-Km adenosine 3':5'-cyclic phosphate phosphodiesterase (PDE), which appear
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::f5594f65e7e097c7b89df96e275552d8
https://pubmed.ncbi.nlm.nih.gov/9285946
https://pubmed.ncbi.nlm.nih.gov/9285946
Regulation of calmodulin gene expression by insulin is both transcriptional and post-transcriptional
Publikováno v:
The Journal of laboratory and clinical medicine. 124(3)
Previously we demonstrated that in streptozotocin-induced or spontaneously diabetic BB rats (BB-SDR), low-Km cyclic AMP (cAMP), phosphodiesterase (PDE), and calmodulin (CaM) are decreased. Isolated fat cells of diabetic animals synthesized less CaM a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::e2d931ac30ff4afe959a1a1f7fbaa7da
https://pubmed.ncbi.nlm.nih.gov/8083570
https://pubmed.ncbi.nlm.nih.gov/8083570
Publikováno v:
Life Sciences. 35:2155-2164
We have identified two different species of inhibitors of calmodulin-dependent cAMP phosphodiesterase: 1) a low molecular weight (LMW) and 2) a high molecular weight (HMW) form. These inhibitors are extracted from rat liver. Both LMW and HMW inhibito
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d5442a8a21271dcf99cd0888b7d094fe
https://doi.org/10.1016/0024-3205(84)90516-2
https://doi.org/10.1016/0024-3205(84)90516-2
Publikováno v:
Diabetes. 36:210-215
Diabetes mellitus in humans is associated with increased plasma and tissue levels of cAMP and decreased cAMP phosphodiesterase (PDE) activity. Calmodulin (CM) is a low-molecular-weight protein essential for activation of cAMP PDE. The inhibitor (INH)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6957ee30f439b736dd8c26bcbfaa8d80
https://doi.org/10.2337/diabetes.36.2.210
https://doi.org/10.2337/diabetes.36.2.210
Autor:
Solomon S. Solomon, M. R. Palazzolo
Publikováno v:
Endocrinology. 96(6)
Insulin has been shown to lower cyclic AMP (cAMP) levels in hormonally sensitive tissue. The mechanism by which this lowering occurs has not yet been fully defined. We studied the effects of insulin on rat adipose tissue cyclic nucleotide phosphodies
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d0676403ea57a55966ef445aa97900c
https://pubmed.ncbi.nlm.nih.gov/165058
https://pubmed.ncbi.nlm.nih.gov/165058
Publikováno v:
Endocrinology. 119(4)
Uncontrolled diabetes in man is associated with increased plasma and tissue levels of cAMP and decreased cAMP phosphodiesterase (PDE) activity. Spontaneously diabetic BB rats (SDR) were used in these experiments. Specific tissues (i.e. liver and epid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fffa66fba01c87f5c67068e20ab5cbad
https://pubmed.ncbi.nlm.nih.gov/3019647
https://pubmed.ncbi.nlm.nih.gov/3019647