Identifying bias in CCR1 antagonists using radiolabelled binding, receptor internalization, β-arrestin translocation and chemotaxis assays

Autor: A, Gilchrist, T D, Gauntner, A, Fazzini, K M, Alley, D S, Pyen, J, Ahn, S J, Ha, A, Willett, S E, Sansom, J L, Yarfi, K A, Bachovchin, M R, Mazzoni, J R, Merritt

Investigators have suggested that the chemokine receptor CCR1 plays a role in multiple myeloma. Studies using antisense and neutralizing antibodies to CCR1 showed that down-regulation of the receptor altered disease progression in a mouse model. More

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::d4d31d699604170ff475c206a69f5d03
http://hdl.handle.net/11568/678292

Regulation of agonist binding to rat ET(B) receptors by cations and GTPgammaS

Autor: F, Ceccarelli, L, Giusti, G, Bigini, B, Costa, D, Grillotti, E, Fiumalbi, A, Lucacchini, M R, Mazzoni

Publikováno v: Biochemical pharmacology. 62(5)

Endothelins exert their physiological effects through interaction with cell surface receptors that are members of the G-protein-coupled receptor family. The endothelin receptor subtype B (ET(B) receptor) is abundantly expressed in rat cerebellum. Sin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::7bad03b30232f3a2a59cb92591fa6794
https://pubmed.ncbi.nlm.nih.gov/11585050

Fluorescent probes as indicators of conformation changes in transducin on activation

Autor: C S, Yang, N P, Skiba, M R, Mazzoni, T O, Thomas, H E, Hamm

Publikováno v: Methods in enzymology. 315

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::aab3e746d63bcb90379245df11651afc
https://pubmed.ncbi.nlm.nih.gov/10736722

Proteolytic fragmentation for epitope mapping

Autor: M R, Mazzoni, N O, Artemyev, H E, Hamm

Publikováno v: Methods in molecular biology (Clifton, N.J.). 66

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::0a6fb76a8527c1bee511a23976fbe232
https://pubmed.ncbi.nlm.nih.gov/8959709

Osteosarcoma cell death induced by innovative scaffolds doped with chemotherapeutics.

Autor: Lanzillotti C; Laboratories of Cell Biology and Molecular Genetics, Department of Medical Sciences, University of Ferrara, Ferrara, Italy., Iaquinta MR; Laboratories of Cell Biology and Molecular Genetics, Department of Medical Sciences, University of Ferrara, Ferrara, Italy., De Pace R; Laboratories of Cell Biology and Molecular Genetics, Department of Medical Sciences, University of Ferrara, Ferrara, Italy., Mosaico M; Laboratories of Cell Biology and Molecular Genetics, Department of Medical Sciences, University of Ferrara, Ferrara, Italy., Patergnani S; Laboratories of Cell Signalling, Department of Medical Sciences, University of Ferrara, Ferrara, Italy., Giorgi C; Laboratories of Cell Signalling, Department of Medical Sciences, University of Ferrara, Ferrara, Italy., Tavoni M; Institute of Science, Technology and Sustainability for Ceramics, National Research Council of Italy (ISSMC-CNR, former ISTEC-CNR), Faenza, Italy., Dapporto M; Institute of Science, Technology and Sustainability for Ceramics, National Research Council of Italy (ISSMC-CNR, former ISTEC-CNR), Faenza, Italy., Sprio S; Institute of Science, Technology and Sustainability for Ceramics, National Research Council of Italy (ISSMC-CNR, former ISTEC-CNR), Faenza, Italy., Tampieri A; Institute of Science, Technology and Sustainability for Ceramics, National Research Council of Italy (ISSMC-CNR, former ISTEC-CNR), Faenza, Italy., Montesi M; Institute of Science, Technology and Sustainability for Ceramics, National Research Council of Italy (ISSMC-CNR, former ISTEC-CNR), Faenza, Italy., Martini F; Laboratories of Cell Biology and Molecular Genetics, Department of Medical Sciences, University of Ferrara, Ferrara, Italy.; Laboratory for Technologies of Advanced Therapies (LTTA), University of Ferrara, Ferrara, Italy., Mazzoni E; Department of Chemical, Pharmaceutical and Agricultural Sciences, University of Ferrara, Ferrara, Italy.

Publikováno v: Journal of cellular physiology [J Cell Physiol] 2024 May; Vol. 239 (5), pp. e31256. Date of Electronic Publication: 2024 Apr 09.