Zobrazeno 1 - 10
of 12
pro vyhledávání: '"M R, Flack"'
Publikováno v:
The Journal of Clinical Endocrinology & Metabolism. 80:824-828
Anti-FSH receptor antibodies, detected using animal systems, have been reported in a few patients with premature ovarian failure (POF). However, assays based on animal receptors may be inappropriate for detecting inhibiting antibodies in humans. Acco
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d7c4aaf09308e2e7689957a6eea9fa74
https://doi.org/10.1210/jcem.80.3.7883837
https://doi.org/10.1210/jcem.80.3.7883837
Publikováno v:
The Journal of Clinical Endocrinology & Metabolism. 80:276-279
Some children with juvenile hypothyroidism exhibit unexplained precocious puberty. Interaction of TSH with the human FSH receptor (hFSH-R) is a possible pathophysiological mechanism for this syndrome that has not been explored due to the lack of hFSH
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bc4f354d13cfcdf25d8dd8a02f1be0d3
https://doi.org/10.1210/jcem.80.1.7829625
https://doi.org/10.1210/jcem.80.1.7829625
Publikováno v:
Endocrinology. 135:2657-2661
Separate sites for glycoprotein hormone receptor binding and signal transduction have yet to be elucidated. In general, certain peptide regions are thought to be critical for receptor binding, whereas the oligosacharides are thought to be important f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::320017a6e2979d854894a9000bef31dd
https://doi.org/10.1210/endo.135.6.7988456
https://doi.org/10.1210/endo.135.6.7988456
Autor:
M. R. Flack
Publikováno v:
Journal of Clinical Endocrinology & Metabolism. 79:756-760
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e6fbc65d0d23a99d018b0aa45066b8b0
https://doi.org/10.1210/jc.79.3.756
https://doi.org/10.1210/jc.79.3.756
Publikováno v:
Journal of Biological Chemistry. 269:14015-14020
To determine the specific role of each follicle-stimulating hormone (FSH) oligosaccharide, we mutated Asn to Gln at each glycosylation site (alpha Gln52, alpha Gln78, alpha Gln52-78, beta Gln7, beta Gln24, and beta Gln7-24) to selectively inhibit oli
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1185b8d0de33cb0ef0f9413ee358834e
https://doi.org/10.1016/s0021-9258(17)36748-0
https://doi.org/10.1016/s0021-9258(17)36748-0
Autor:
M. R. Flack
Publikováno v:
Journal of Clinical Endocrinology & Metabolism. 76:1019-1024
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d267cbe404d9115bb15f66346adde6f5
https://doi.org/10.1210/jc.76.4.1019
https://doi.org/10.1210/jc.76.4.1019
Publikováno v:
The Journal of clinical endocrinology and metabolism. 79(3)
FSH has four asparagine-linked oligosaccharides with variable sialic acid contents, so that FSH is not a single molecule, but a heterogeneous group of isoforms. These isoforms differ in their biological properties and their distribution changes in va
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc00693025472abd1c4974f663632660
https://pubmed.ncbi.nlm.nih.gov/8077357
https://pubmed.ncbi.nlm.nih.gov/8077357
Publikováno v:
The Journal of biological chemistry. 269(19)
To determine the specific role of each follicle-stimulating hormone (FSH) oligosaccharide, we mutated Asn to Gln at each glycosylation site (alpha Gln52, alpha Gln78, alpha Gln52-78, beta Gln7, beta Gln24, and beta Gln7-24) to selectively inhibit oli
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::f43261c6246e65a046efcb47e28f7a90
https://pubmed.ncbi.nlm.nih.gov/8188681
https://pubmed.ncbi.nlm.nih.gov/8188681
Autor:
M R Flack, Nancy Mullen, R G Pyle, Bruce C. Nisula, R A Knazek, M M Reidenberg, Y W Wu, B Lorenzo
Publikováno v:
The Journal of clinical endocrinology and metabolism. 76(4)
Medical treatment of metastatic adrenal cancer is largely unsuccessful and has considerable toxicity. We previously demonstrated the activity of the plant toxin gossypol against human adrenal cancers in nude mice. We therefore examined the efficacy a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::258a58bb4abe3ec7eb44f8fe9923fe53
https://pubmed.ncbi.nlm.nih.gov/8473376
https://pubmed.ncbi.nlm.nih.gov/8473376
Autor:
Bruce D. Weintraub, C. A. Zimmerman, R. K. Desai, R. W. Lash, T. Yoshida, F E Wondisford, M. R. Flack
Publikováno v:
Journal of endocrinological investigation. 15(4)
In recent studies, site-directed mutagenesis has been used to alter the tripeptide glycosylation recognition sequences of glycoprotein hormone subunits, thereby affecting their structure and function. However, it is not known whether these effects re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0cbbb41dda58325df54029fb8c91085f
https://pubmed.ncbi.nlm.nih.gov/1512415
https://pubmed.ncbi.nlm.nih.gov/1512415