Zobrazeno 1 - 10
of 11
pro vyhledávání: '"M R, Feng"'
Publikováno v:
Xenobiotica. 28:413-426
1. Radiometric and UV analyses indicated95% unchanged cobalt mesoporphyrin (CoMP) in plasma after i.v. or i.m. administration. Blood clearance of CoMP is2% of hepatic blood flow in mouse and rat, and0.5% of hepatic blood flow in monkey and dog. CoMP
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b3eaa5644623ec7146128aa81082e7a5
https://doi.org/10.1080/004982598239515
https://doi.org/10.1080/004982598239515
Autor:
M R Feng, D S Wright, C A Strenkoski, C L Christoffersen, A E Corbin, Y Wang, Leonard T. Meltzer, E V Tucker, James N. Wiley, Thomas G. Heffner, F W Ninteman
Publikováno v:
Pharmaceutical Research. 14:329-336
Purpose. To study the pharmacokinetics (PK) and pharmacodynamics (PD) of an investigational antipsychotic agent, CI-1007, in rats and monkeys. Methods. CI-1007 and a pharmacologically active metabolite, PD 147693 (Ml), were evaluated in animal antips
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7b3b39c31d10424c97038a2f13b08540
https://doi.org/10.1023/a:1012050121937
https://doi.org/10.1023/a:1012050121937
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 313(3)
Pregabalin (PGB) is a novel drug under development for the treatment of epilepsy, neuropathic pain, fibromyalgia, and generalized anxiety disorder. In this study, we investigated PGB transport in rats, mammalian cell lines, and Xenopus laevis oocytes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::30f87b7a646b6d0ab69057f2010cb1f2
https://pubmed.ncbi.nlm.nih.gov/15769862
https://pubmed.ncbi.nlm.nih.gov/15769862
Autor:
L Y, Hu, T R, Ryder, M F, Rafferty, K M, Siebers, T, Malone, A, Chatterjee, M R, Feng, S M, Lotarski, D M, Rock, S J, Stoehr, C P, Taylor, M L, Weber, G P, Miljanich, E, Millerman, B G, Szoke
Publikováno v:
Drug design and discovery. 17(1)
Several novel N-type voltage sensitive calcium channel blockers showed high affinity in the IMR32 assay and efficacy in the anti-writhing model. Herein, we describe the design, synthesis, SAR studies, biological data, physicochemical properties and p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::382704345de2c1326eb0cae55033ad48
https://pubmed.ncbi.nlm.nih.gov/10928451
https://pubmed.ncbi.nlm.nih.gov/10928451
Publikováno v:
Pharmaceutical research. 17(4)
To evaluate (1) allometric scaling of systemic clearance (CL) using unbound drug concentration, (2) the potential usage of brain weight (BRW) correction in allometric scaling of both CL and oral clearance (CL/F).Human clearance was predicted allometr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::c101346ee4ded29054bc82b2d9452b52
https://pubmed.ncbi.nlm.nih.gov/10870984
https://pubmed.ncbi.nlm.nih.gov/10870984
Autor:
G P Miljanich, Mark L. Weber, David M. Rock, B G Szoke, Lain-Yen Hu, Sally J. Stoehr, Todd Robert Ryder, Michael Sinz, Michael Francis Rafferty, Elizabeth Millerman, Yong-Xiang Wang, Susan M. Lotarski, S. Scott Bowersox, Charles Taylor, M R Feng
Publikováno v:
Journal of medicinal chemistry. 42(20)
In this article, the rationale for the design, synthesis, and biological evaluation of a series of N-type voltage-sensitive calcium channel (VSCC) blockers is described. N-Type VSCC blockers, such as ziconotide, have shown utility in several models o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5717d41b5b94e5d2230840d4c36c644a
https://pubmed.ncbi.nlm.nih.gov/10514294
https://pubmed.ncbi.nlm.nih.gov/10514294
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 26(10)
The disposition of CI-1007 (I), an antipsychotic dopamine agonist, was studied after iv or po administration to rats, monkeys, and dogs and po administration to human cytochrome P450 2D6 extensive metabolizers (EMs). I was extensively metabolized aft
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::1b8abe2005b710f55fe254b30e32fb70
https://pubmed.ncbi.nlm.nih.gov/9763403
https://pubmed.ncbi.nlm.nih.gov/9763403
Autor:
M R, Feng, A E, Corbin, Y, Wang, C L, Christoffersen, J N, Wiley, C A, Strenkoski, E V, Tucker, F W, Ninteman, L T, Meltzer, T G, Heffner, D S, Wright
Publikováno v:
Pharmaceutical research. 14(3)
To study the pharmacokinetics (PK) and pharmacodynamics (PD) of an investigational antipsychotic agent, CI-1007, in rats and monkeys.CI-1007 and a pharmacologically active metabolite, PD 147693 (M1), were evaluated in animal antipsychotic tests (inhi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::0d62a2cafc196dcb1f1ac84f1a115617
https://pubmed.ncbi.nlm.nih.gov/9098876
https://pubmed.ncbi.nlm.nih.gov/9098876
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Akademický článek
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