Zobrazeno 1 - 10
of 29
pro vyhledávání: '"M R, DeLong"'
Autor:
Ikuma Hamada, M. R. DeLong
Publikováno v:
Journal of Neurophysiology. 68:1850-1858
1. To examine the role of the subthalamic nucleus (STN) in the pathogenesis of dyskinesias, the STN was experimentally lesioned with fiber-sparing excitotoxins in two awake monkeys. 2. A combined recording-injection device was used to locate and lesi
Autor:
T, Wichmann, M R, DeLong
Publikováno v:
Journal of neural transmission. Supplementum. (70)
In the traditional model of the pathophysiology of parkinsonism, parkinsonian motor signs are viewed as the result of changes in discharge rates in the basal ganglia. However, not all experimental findings can be explained by rate changes alone, and
Autor:
L, Alvarez, R, Macias, J, Guridi, G, Lopez, E, Alvarez, C, Maragoto, J, Teijeiro, A, Torres, N, Pavon, M C, Rodriguez-Oroz, L, Ochoa, H, Hetherington, J, Juncos, M R, DeLong, J A, Obeso
Publikováno v:
Movement disorders : official journal of the Movement Disorder Society. 16(1)
We report our experience of unilateral subthalamotomy in patients with Parkinson's disease (PD). Eleven patients were included in a pilot, open-labeled study to assess the effect of unilateral lesion of the subthalamic nucleus (STN) with a minimum of
Publikováno v:
The Journal of comparative neurology. 429(3)
As a result of the frequent performance of lesioning and electrical stimulation procedures targeting the globus pallidus internus (GPi) to treat medically intractable hypokinetic and hyperkinetic movement disorders, the course of the pallidothalamic
Publikováno v:
Annals of neurology. 47(4 Suppl 1)
The anatomical and physiological basis of levodopa-induced dyskinesias (LIDs) in patients with Parkinson's disease (PD) is reviewed in the light of the current model for the organization of the basal ganglia. This model, which was developed in the la
Publikováno v:
Movement disorders : official journal of the Movement Disorder Society. 15(2)
To assess the long-term outcome following unilateral pallidotomy for advanced Parkinson's disease, we performed nonblinded Core Assessment Program for Intracerebral Transplantations protocol assessments in 10 of the original 15 patients in our pilot
Publikováno v:
Advances in neurology. 78
Autor:
T, Wichmann, M R, DeLong
Publikováno v:
Neurosurgery clinics of North America. 9(2)
Movement disorders are categorized as hypokinetic (Parkinson's disease) or hyperkinetic (Huntington's disease, hemiballism, or dystonia). Neuroscience research over the last several years, using data obtained in animal models for these disorders and
Publikováno v:
Advances in neurology. 74
Publikováno v:
Clinical neurosurgery. 44
1. Microeletrode mapping of the pallidum and adjacent structures allows for precise target identification and localization of critical structures, i.e., optic tract, internal capsule, and external pallidum, which must be spared from lesioning. 2. Mic