Zobrazeno 1 - 8
of 8
pro vyhledávání: '"M R, Brzezinski"'
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 27(11)
We investigated the catalysis of drug monooxygenation by human embryonic hepatic tissues at a very early stage of gestation (days 52-59). Imipramine was used as a model substrate and the metabolites generated were identified and quantified by electro
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 289(3)
Cytochrome P-450 2E1 (CYP2E1) is a readily inducible hemoprotein that catalyzes the oxidation of endogenous compounds and many low molecular weight xenobiotics. As the major component of the microsomal ethanol oxidizing system, it contributes signifi
Publikováno v:
Biochemical pharmacology. 57(7)
Biotransformation of all-trans-retinol (t-ROH) and all-trans-retinal (t-RAL) to all-trans-retinoic acid (t-RA) in human prenatal hepatic tissues (53-84 gestational days) was investigated with HPLC using human adult hepatic tissues as positive control
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 25(9)
Purified human liver carboxylesterase (hCE-1) catalyzes the hydrolysis of cocaine to form benzoylecgonine, the deacetylation of heroin to form 6-acetylmorphine, and the ethanol-dependent transesterification of cocaine to form cocaethylene. In this st
Publikováno v:
NIDA research monograph. 173
Publikováno v:
NIDA research monograph. 173
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 279(2)
Concomitant i.v. use of cocaine and heroin ("speedballing") is prevalent among drug-abusing populations. Heroin is rapidly metabolized by sequential deacetylation of two separate ester bonds to yield 6-monoacetylmorphine and morphine. Hydrolysis of h
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 275(2)
The tissue distribution of cocaine methyl esterase and ethanol-dependent ethyl transferase activities was determined in the rat and compared to the tissue distribution of three distinct non-specific hydrolases. Rates of formation of benzoylecgonine f