Zobrazeno 1 - 10
of 13
pro vyhledávání: '"M R, Bleavins"'
Publikováno v:
Journal of Applied Toxicology. 20:25-34
This study was conducted to characterize better the response of rats to blood loss and hemolysis and to incorporate automated methods into the routine evaluations of those responses. Serial phlebotomies of 1.5-2.0 ml of blood per day for 5 days, or i
Publikováno v:
Methods in molecular medicine. 49
The microsomal enzyme cytochrome P450 2D6 (CYP2D6), also known as debrisoquine 4-hydroxylase, is involved in the oxidative metabolism of many widely used drugs, including neuroleptics, tricyclic antidepressants, antiarrhythmics, and β-adrenergic blo
Publikováno v:
Journal of applied toxicology : JAT. 20(1)
This study was conducted to characterize better the response of rats to blood loss and hemolysis and to incorporate automated methods into the routine evaluations of those responses. Serial phlebotomies of 1.5-2.0 ml of blood per day for 5 days, or i
Publikováno v:
Research communications in molecular pathology and pharmacology. 103(1)
A high-throughput genotyping method has been developed to detect gene deletion polymorphisms of glutathione-S-transferase theta and mu (GSTT1 and GSTM1). This method utilizes the 5'-nuclease activity of Taq polymerase in conjunction with fluorogenic
Autor:
T S, Gipson, N M, Bless, T P, Shanley, L D, Crouch, M R, Bleavins, E M, Younkin, V, Sarma, D F, Gibbs, W, Tefera, P C, McConnell, W T, Mueller, K J, Johnson, P A, Ward
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 162(6)
Inflammatory lung injury is probably regulated by the balance between proteases and protease inhibitors together with oxidants and antioxidants, and proinflammatory and anti-inflammatory cytokines. Rat tissue inhibitor of metalloprotease-2 (TIMP-2) a
Publikováno v:
Toxicological sciences : an official journal of the Society of Toxicology. 46(2)
Molecular analysis of alterations in genomic DNA is essential for understanding mechanisms by which chemical agents induce or modify tumor development. The assessment of microsatellite polymorphisms, loss of heterozygosity, mutations, and gene rearra
Publikováno v:
Cytometry. 32(1)
Preclinical drug trials frequently require the evaluation of animal bone marrow, a time-consuming process requiring the skills of a highly trained hematologist. In the present study, a flow cytometric technique was developed that could effectively re
Publikováno v:
Cytometry. 32(1)
Previously, flow cytometric determination of peroxidase activity, cell size, and reactivity to lymphocyte antibodies were used to produce bone marrow differentials in untreated rats. In the present study, abnormal hematologic profiles were induced wi
Publikováno v:
The American journal of pathology. 148(4)
All-trans retinoic acid (RA) preserves human dermal fibroblast viability and stimulates proliferation in vitro. These effects are mediated, at least in part, by reducing the extracellular Ca2+ requirement. The same concentrations of RA that reduce th
Publikováno v:
Archives of Environmental Contamination and Toxicology. 28
To assess the involvement of T-lymphocytes in ozone-induced lung damage, CD-1 mice were exposed to air or 0.7 ppm ozone (1.37 mg O3/m3 air) in the presence and absence of the immunosuppressive drug cyclosporine A (CSA). Mice were thus divided into fo