Zobrazeno 1 - 10
of 18
pro vyhledávání: '"M R, Badgett"'
Publikováno v:
Virology. 341:141-152
The order of genes in the genome is commonly thought to have functional significance for gene regulation and fitness but has not heretofore been tested experimentally. We adapted a bacteriophage T7 variant harboring an ectopically positioned RNA poly
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::91ca58f0168803d869b2a6856cd1c77f
https://doi.org/10.1016/j.virol.2005.07.008
https://doi.org/10.1016/j.virol.2005.07.008
Publikováno v:
Evolution. 58:692-701
Eight bacteriophages were adapted for rapid growth under similar conditions to compare their evolved, endpoint fitnesses. Four pairs of related phages were used, including two RNA phages with small genomes (MS2 and Qbeta) two single-stranded DNA phag
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c6835cb41b88c29de87ba5bc1a12a2b4
https://doi.org/10.1111/j.0014-3820.2004.tb00402.x
https://doi.org/10.1111/j.0014-3820.2004.tb00402.x
Publikováno v:
Journal of Molecular Evolution. 57:241-248
Two lines of the bacteriophage T7 were grown to fix mutations indiscriminately, using a combination of population bottlenecks and mutagenesis. Complete genome sequences revealed 404 and 299 base substitutions in the two lines, the largest number char
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ebb001eb69fac83e8165782c9a31e87
https://doi.org/10.1007/s00239-003-2470-1
https://doi.org/10.1007/s00239-003-2470-1
Publikováno v:
Journal of Virology. 76:10524-10529
The genetic trajectory leading to viral attenuation was studied in a canine parvovirus (CPV) strain grown on dog kidney cells for 115 transfers. Consensus sequences of viral populations at passages 0, 3, 30, 50, 80, and 115 were obtained from PCR pro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a4dad601e52d27655aba8440c45afef
https://doi.org/10.1128/jvi.76.20.10524-10529.2002
https://doi.org/10.1128/jvi.76.20.10524-10529.2002
Publikováno v:
Molecular Microbiology. 28:835-846
Summary RNA coliphage SP was propagated for several generations on a host expressing an inhibitory antisense RNA complementary to bases 31‐270 of the positivestranded genome. Phages evolved that escaped inhibition. Typically, these escape mutants c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d38a2f55a0f2e1d0f7815e2e7c9194da
https://doi.org/10.1046/j.1365-2958.1998.00847.x
https://doi.org/10.1046/j.1365-2958.1998.00847.x
Publikováno v:
Journal of Molecular Evolution. 53:47-54
Bacteriophage T7 was challenged with either of two toxic genes expressed from plasmids. Each plasmid contained a different gene downstream of a T7 promoter; cells harboring each plasmid caused an infection by wild-type T7 to abort. T7 evolved resista
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ead1282036a3c9c02ae1f17c5706b85a
https://doi.org/10.1007/s002390010191
https://doi.org/10.1007/s002390010191
Publikováno v:
Molecular Biology and Evolution. 17:942-950
High temperature inhibits the growth of the wild-type bacteriophage phiX174. Three different point mutations were identified that each recovered growth at high temperature. Two affected the major capsid protein (residues F188 and F242), and one affec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d17495ce143e7aa933e38726cf3eb9c
https://doi.org/10.1093/oxfordjournals.molbev.a026375
https://doi.org/10.1093/oxfordjournals.molbev.a026375
Autor:
A. Gulati, David M. Hillis, C. Ho, Holly A. Wichman, Ian J. Molineux, M. R. Badgett, James J. Bull, John P. Huelsenbeck
Publikováno v:
Genetics. 147:1497-1507
Replicate lineages of the bacteriophage ϕX 174 adapted to growth at high temperature on either of two hosts exhibited high rates of identical, independent substitutions. Typically, a dozen or more substitutions accumulated in the 5.4-kilobase genome
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aed8af978baf1c627818f7d3e78da223
https://doi.org/10.1093/genetics/147.4.1497
https://doi.org/10.1093/genetics/147.4.1497
Publikováno v:
Development. 111:425-436
The myoplasm of ascidian eggs is a localized cytoskeletal domain that is segregated to presumptive larval tail muscle cells during embryonic development. We have identified a cytoskeletal protein recognized by a vertebrate neurofilament monoclonal an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b6d6a39ae017b1e4c8376ed66cf1e797
https://doi.org/10.1242/dev.111.2.425
https://doi.org/10.1242/dev.111.2.425
Publikováno v:
Science. 285:422-424
The molecular basis of adaptation is a major focus of evolutionary biology, yet the dynamic process of adaptation has been explored only piecemeal. Experimental evolution of two bacteriophage lines under strong selection led to over a dozen nucleotid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ff5ea27889bbb7a76f2ac9e6a8d104e
https://doi.org/10.1126/science.285.5426.422
https://doi.org/10.1126/science.285.5426.422