Cognitive and Motor Decline in Dementia with Lewy Bodies and Parkinson's Disease Dementia

Autor: Gonzalez MC, Tovar-Rios DA, Alves G, Dalen I, Williams-Gray CH, Camacho M, Forsgren L, Backstrom D, Lawson RA, Macleod AD, Counsell CE, Paquet C, DeLena C, D'Antonio F, Pilotto A, Padovani A, Blanc F, Falup-Pecurariu C, Lewis SJG, Rejdak K, Papuc E, Hort J, Nedelska Z, O'Brien J, Bonanni L, Marquie M, Boada M, Pytel V, Abdelnour C, Alcolea D, Beyer K, Tysnes O-B, Aarsland D, Maple-Grodem J

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3ffa948518df266e5210228d1d7f3585

A randomised, double-blind, placebo-controlled trial of repeated nebulisation of non-viral cystic fibrosis transmembrane conductance regulator (CFTR) gene therapy in patients with cystic fibrosis

Autor: Eric WFW Alton, David K Armstrong, Deborah Ashby, Katie J Bayfield, Diana Bilton, Emily V Bloomfield, A Christopher Boyd, June Brand, Ruaridh Buchan, Roberto Calcedo, Paula Carvelli, Mario Chan, Seng H Cheng, David S Collie, Steve Cunningham, Heather E Davidson, Gwyneth Davies, Jane C Davies, Lee A Davies, Maria H Dewar, Ann Doherty, Jackie Donovan, Natalie S Dwyer, Hala I Elgmati, Rosanna F Featherstone, Jemyr Gavino, Sabrina Gea-Sorli, Duncan M Geddes, James SR Gibson, Deborah R Gill, Andrew P Greening, Uta Griesenbach, David M Hansell, Katharine Harman, Tracy E Higgins, Samantha L Hodges, Stephen C Hyde, Laura Hyndman, J Alastair Innes, Joseph Jacob, Nancy Jones, Brian F Keogh, Maria P Limberis, Paul Lloyd-Evans, Alan W Maclean, Michelle C Manvell, Dominique McCormick, Michael McGovern, Gerry McLachlan, Cuixiang Meng, M Angeles Montero, Hazel Milligan, Laura J Moyce, Gordon D Murray, Andrew G Nicholson, Tina Osadolor, Javier Parra-Leiton, David J Porteous, Ian A Pringle, Emma K Punch, Kamila M Pytel, Alexandra L Quittner, Gina Rivellini, Clare J Saunders, Ronald K Scheule, Sarah Sheard, Nicholas J Simmonds, Keith Smith, Stephen N Smith, Najwa Soussi, Samia Soussi, Emma J Spearing, Barbara J Stevenson, Stephanie G Sumner-Jones, Minna Turkkila, Rosa P Ureta, Michael D Waller, Marguerite Y Wasowicz, James M Wilson, Paul Wolstenholme-Hogg, on behalf of the UK Cystic Fibrosis Gene Therapy Consortium

Publikováno v: Efficacy and Mechanism Evaluation, Vol 3, Iss 5 (2016)

Background: Cystic fibrosis (CF) is a chronic, life-limiting disease caused by mutations in the CF transmembrane conductance regulator (CFTR) gene leading to abnormal airway surface ion transport, chronic lung infections, inflammation and eventual re

Externí odkaz: https://doaj.org/article/09b29fe1b155492fba24a177fe4be24c

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Technological Innovations in the Use of 360 Feedback for Performance Management

Autor: Joe Sherwood, Steven T. Hunt, Lauren M. Pytel

Publikováno v: Handbook of Strategic 360 Feedback

This chapter discusses how innovations in 360 Feedback are enabling significant improvements in performance management. This information resulted from asking the question: What are the most effective ways to use performance management technology to p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b7cc6e0bb4162d1ff740a9f2a439ecc0
https://doi.org/10.1093/oso/9780190879860.003.0005

The murine lung as a factory to produce secreted intrapulmonary and circulatory proteins

Autor: Kamila M Pytel, Jean-François Gélinas, Deborah R. Gill, Lee A. Davies, Amit C. Nathwani, Stephen C. Hyde, Lidia Cammack, Makoto Inoue, Ian A. Pringle, Caroline Moran, Eric W.F.W. Alton, S Tsugumine, Michael C. Paul-Smith, Mario Chan, Takashi Hironaka, Loren Cameron, Cuixiang Meng, Uta Griesenbach, Jenny McIntosh, Robyn V. Bell

Publikováno v: Gene Therapy

We have shown that a lentiviral vector (rSIV.F/HN) pseudotyped with the F and HN proteins from Sendai virus generates high levels of intracellular proteins after lung transduction. Here, we evaluate the use of rSIV.F/HN for production of secreted pro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::79e3b640266d52e588db1236db1240c8
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