Zobrazeno 1 - 10
of 34
pro vyhledávání: '"M Prack"'
Autor:
Mary Ellen Cvijic, Margaret M. Prack, Janet Kolb, Steve Nadler, Rolf Ryseck, Kimberly Nowak, Yingjie Zhu, Michele Agler, Taosheng Chen, Ding Shen, John Somerville
Publikováno v:
SLAS Discovery. 12:1029-1041
Ligand-induced cytoplasm to nucleus translocation is a critical event in the nuclear receptor (NR) signal transduction cascade. The development of green fluorescent proteins and their color variants fused with NRs, along with the recent developments
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d9d3293cd7baced80a23c27fff107698
https://doi.org/10.1177/1087057107309353
https://doi.org/10.1177/1087057107309353
Autor:
Joseph Tamasi, Jean H.M. Feyen, Jacques Y. Roberge, Xiaodong Wang, Yu Dong, Zhaoqing Wang, R. Michael Lawrence, Margaret M. Prack, Dora M. Schnur, Vanessa Dell, Yalei Liu, Rajasree Golla, Michele Agler, James R. Corte, Ramakrishna Seethala, Monique Anthony, Tianan Fang, John K. Dickson
Publikováno v:
Steroids. 69:201-217
The identification of a new series of selective nonsteroidal progesterone receptor (PR) agonists is reported. Using a high-throughput screening assay based on the measurement of transactivation of a mouse mammary tumor virus promoter-driven luciferas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09ffe5a99e07a3272ec5e2b8be155956
https://doi.org/10.1016/j.steroids.2003.12.007
https://doi.org/10.1016/j.steroids.2003.12.007
Autor:
Ramesh Padmanabha, Samuel Gerritz, Lorin A. Thompson, Joseph L. Cantone, Michele Agler, Dieter M. Drexler, Tracey Hall, David G. Harden, Rudy Krause, Charles F. Albright, Tatyana Zvyaga, Xiaoliang Zhuo, Victoria Wong, Jianliang Shi, Craig Polson, James E. Grace, Jeremy H. Toyn, Kim Esposito, Kimberly Snow, Valerie Guss, Maria Pierdomenico, John Morrison, Lawrence R. Marcin, Sam Varma, Jere E. Meredith, Cong Wei, Sethu Sankaranararyanan, John E. Macor, Mendi A. Higgins, Kimberley A. Lentz, Xu-Alan Lin, Joseph Raybon, Carol M. Krause, Michael K. Ahlijanian, Margaret M. Prack, Catherine R. Burton, Lawrence G. Iben, Richard E. Olson, Alan S. Robertson, Rex Denton, Yingjie Zhu
Publikováno v:
International Journal of Alzheimer's Disease, Vol 2014 (2014)
International Journal of Alzheimer's Disease
International Journal of Alzheimer's Disease
Alzheimer’s disease is the most prevalent cause of dementia and is associated with accumulation of amyloid-βpeptide (Aβ), particularly the 42-amino acid Aβ1-42, in the brain. Aβ1-42 levels can be decreased byγ-secretase modulators (GSM), which
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::32a200c84c75814b878131607c3b7c2d
Publikováno v:
Journal of Lipid Research, Vol 30, Iss 9, Pp 1397-1403 (1989)
Isocaloric substitution of polyunsaturated fat for saturated fat reduces concentrations of total plasma cholesterol and high density lipoproteins (HDL) in nonhuman primates. The biochemical mechanisms through which polyunsaturated fat lowers plasma H
Externí odkaz:
https://doaj.org/article/eff4eef32c7545d5a4f9888b0a6ad0fc
Autor:
Joanne J. Bronson, Adam Hendricson, Ryan Westphal, John E. Macor, Lisa Hunihan, Margaret M. Prack, Jeffrey M. Brown, David G. Harden, Robert G. Gentles, Rudy Krause, Carolyn Diane Dzierba
Publikováno v:
Journal of neurochemistry. 129(2)
NMDA receptor hypofunction is hypothesized to contribute to cognitive deficits associated with schizophrenia. Since direct activation of NMDA receptors is associated with serious adverse effects, modulation of the NMDA co-agonists, glycine or D-serin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc37d3dc783057cadcf89f9b25fea647
https://pubmed.ncbi.nlm.nih.gov/24266811
https://pubmed.ncbi.nlm.nih.gov/24266811
Publikováno v:
Journal of Biological Chemistry. 267:17933-17938
We have previously reported that steroidogenesis is dramatically reduced in mouse Y1 adrenocortical cells which express the human apolipoprotein E gene (Y1-E cells). This suppression results in part from inhibition of cAMP-mediated events. In this re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9abf8112b1897e26ac35d5fa4e955772
https://doi.org/10.1016/s0021-9258(19)37132-7
https://doi.org/10.1016/s0021-9258(19)37132-7
Publikováno v:
Molecular Endocrinology. 6:288-298
Previous studies showed that apolipoprotein-E (apoE) mRNA is regulated in rat adrenal gland by treatments that alter adrenal gland cholesterol content and steroidogenesis. In the present study cell types expressing apoE mRNA were determined by in sit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd4e1c0559f23a4fa08fb11410ea1519
https://doi.org/10.1210/mend.6.2.1373819
https://doi.org/10.1210/mend.6.2.1373819
Publikováno v:
Journal of Lipid Research, Vol 32, Iss 10, Pp 1611-1618 (1991)
Among extrahepatic tissues the adrenal gland has one of the highest concentrations of apoE mRNA and the highest rate of apoE synthesis. In the present investigation several previously described in vivo treatments were used to assess the relationship
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4cf912244dc91dbe83ef44a8e1532371
http://www.sciencedirect.com/science/article/pii/S0022227520416463
http://www.sciencedirect.com/science/article/pii/S0022227520416463
Publikováno v:
Proceedings of the National Academy of Sciences. 88:2375-2379
The lipid transport protein, apolipoprotein E (apoE), is expressed in many peripheral tissues in vivo including the adrenal gland and testes. To investigate the role of apoE in adrenal cholesterol homeostasis, we have expressed a human apoE genomic c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4698623048785b87e98607e6844ebe43
https://doi.org/10.1073/pnas.88.6.2375
https://doi.org/10.1073/pnas.88.6.2375
Publikováno v:
Journal of Clinical Investigation. 87:470-475
The effects of the nephrotic syndrome in rats on the cholesterol content and the biosynthesis of apolipoprotein E (apoE) by resident peritoneal macrophages have been investigated. Since the nephrotic syndrome has been associated with an increased ris
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8febc90c97f71aae6e6e58f9657f24ca
https://doi.org/10.1172/jci115019
https://doi.org/10.1172/jci115019