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72 The butterfly project – improving treatment escalation planning in the emergency department

Autor: Sarah Edwards, Jamila Salim, Margaret M. Platts, Sofia Gildoni, Karen Murray, Kate Russ, Dianne Jackson, Jeanette Simpson-Millard, Lisa Keillor, Freya Satchell

Publikováno v: Poster presentations.

Background The 2017 End of Life Care Hospital Improvement Programme (ELCHIP) audit of deaths at the Leicester Royal Infirmary (LRI) an Emergency Department (ED) attendance may be an opportunity to proactively identify and plan for deterioration. The

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c7d8252771037fe62dd05352ee44f892
https://doi.org/10.1136/spcare-2021-pcc.90

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Reciprocal age-related changes in GAP-43/B-50, substance P and calcitonin gene-related peptide (CGRP) expression in rat primary sensory neurones and their terminals in the dorsal horn of the spinal cord and subintima of the knee synovium

Autor: Mika Hukkanen, Steven A. Corbett, L. A. M. Platts, Seppo Santavirta, Julia M. Polak, Yrjö T. Konttinen

Publikováno v: Neuroscience Research. 42:251-260

Age-related changes in the expression of the growth associated protein GAP-43/B-50, and the neuropeptides substance P and calcitonin gene-related peptide (CGRP) were investigated in the sensory neurones of rat dorsal root ganglia, dorsal horns of the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3cb2b65810e011bfaa0f37050630889f
https://doi.org/10.1016/s0168-0102(02)00003-2

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Induction of inducible nitric oxide synthase, argininosuccinate synthase, and GTP cyclohydrolase I in arthritic joints of human tumor necrosis factor-alpha transgenic mice

Autor: Mika, Hukkanen, Louise A M, Platts, Sylva, Haralambous, Mari, Ainola, Yrjö T, Konttinen, George, Kollias, Julia M, Polak

Publikováno v: The Journal of rheumatology. 30(4)

Transgenic mice that express human tumor necrosis factor-alpha (Tg197 h-TNF-alpha) develop polyarthritis at 3 to 4 weeks of age leading to severe joint destruction at 8 to 10 weeks of age. Studies have suggested that inducible nitric oxide synthase (

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::8600e2baa6a332d47b35ba5c08f9d055
https://pubmed.ncbi.nlm.nih.gov/12672181

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Effect of nitric oxide donor nitroglycerin on bone mineral density in a rat model of estrogen deficiency-induced osteopenia

Autor: Julia M. Polak, Mika Hukkanen, T Lawes, L. A. M. Platts, Yrjö T. Konttinen, Iain MacIntyre, A.E Goodship, S.I Girgis

Publikováno v: Bone. 32(2)

Nitric oxide (NO) may modulate estrogen's anabolic effects on bone homeostasis by restraining osteoclast-mediated bone resorption and stimulation of osteoblast activity. Accordingly, NO donated by organic nitrates, including nitroglycerin, is thought

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7671bd20cdc69b4ee06b659b29d0c9c6
https://pubmed.ncbi.nlm.nih.gov/12633786

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Mechanical strain stimulates nitric oxide production by rapid activation of endothelial nitric oxide synthase in osteocytes

Autor: L. A. M. Platts, Andrew A. Pitsillides, John R. Mosley, M. Hukkanen, Lance E. Lanyon, Rosemary F. L. Suswillo, Gul Zaman, Julia M. Polak, Simon C.F. Rawlinson, Ming Zhao Cheng

Publikováno v: Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. 14(7)

Previous studies have indicated that physiological levels of dynamic mechanical strain produce rapid increases in nitric oxide (NO) release from rat ulna explants and primary cultures of osteoblast-like cells and embryonic chick osteocytes derived fr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb7b8836a778533e8ba2e90df69bb940
https://pubmed.ncbi.nlm.nih.gov/10404012

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Developmental regulation of nitric oxide synthase expression in rat skeletal bone

Autor: L. A. M. Platts, Iñigo Fernandez de Marticorena, Iain MacIntyre, Julia M. Polak, M. Hukkanen, Meg C. O'Shaughnessy

Publikováno v: Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. 14(6)

Nitric oxide (NO) has been implicated in bone growth and remodeling by studies showing that inhibition of NO-synthase (NOS) activity retards normal gain in bone mineral density both during skeletal development and after sexual maturity. In the presen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ea22f49805a4ee2d9f671763f11ac39
https://pubmed.ncbi.nlm.nih.gov/10352094

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The provision and use of medical services during the 1991 World Student Games in Sheffield

Autor: D R, Hannay, B K, English, T P, Usherwood, M, Platts

Publikováno v: Journal of public health medicine. 15(3)

This paper describes the provision and use of medical services organized by Sheffield during the World Student Games in 1991. A descriptive study of medical and physio-therapy records, together with minor incident logs and hospital referrals, was car

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::b4f64257f8b9d0cf7bcf887356a2b052
https://pubmed.ncbi.nlm.nih.gov/8251203

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