Zobrazeno 1 - 10
of 107
pro vyhledávání: '"M Pfleger"'
Autor:
Theresa A Reimels, Mia Steinberg, Hua Yan, Sivan Shahar, Ashley Rosenberg, Kristina Kalafsky, Max Luf, Lindsay Kelly, Stacia Octaviani, Cathie M Pfleger
Publikováno v:
PLoS ONE, Vol 19, Iss 10, p e0312274 (2024)
Rabex-5 (also called RabGEF1), a protein originally characterized for its Rab5 GEF function, also has an A20-like E3 ubiquitin ligase domain. We and others reported that Rabex-5 E3 activity promotes Ras mono- and di-ubiquitination to inhibit Ras sign
Externí odkaz:
https://doaj.org/article/1948ec6193b948dd952c77dcc807546d
Autor:
Chalita Washington, Rachel Chernet, Rewatee H Gokhale, Yesenia Martino-Cortez, Hsiu-Yu Liu, Ashley M Rosenberg, Sivan Shahar, Cathie M Pfleger
Publikováno v:
PLoS Genetics, Vol 16, Iss 6, p e1008715 (2020)
Dysregulation of the Ras oncogene in development causes developmental disorders, "Rasopathies," whereas mutational activation or amplification of Ras in differentiated tissues causes cancer. Rabex-5 (also called RabGEF1) inhibits Ras by promoting Ras
Externí odkaz:
https://doaj.org/article/5aa33f8f592c4a1384e4c95b809cb481
Publikováno v:
Circulation Research. 131
Obesity and type 2 diabetes represent a surging public health crisis, impacting nearly half of American adults. Heart failure is a leading cause of mortality and morbidity in patients with diabetes and obesity. Much remains unknown regarding the mole
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cf25ecdd79cc1a25b032ff45757e800c
https://doi.org/10.1161/res.131.suppl_1.p1074
https://doi.org/10.1161/res.131.suppl_1.p1074
Publikováno v:
Circulation Research. 131
Insulin resistance (IR) is a hallmark of type II diabetes (TIID) and causes cardiac dysfunction independent of hypertension and coronary artery disease, or diabetic cardiomyopathy (DC). Impaired metabolism and energetics are a major cause of DC, howe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4fe0bc93526edc9aafea5bb663f492a5
https://doi.org/10.1161/res.131.suppl_1.ec103
https://doi.org/10.1161/res.131.suppl_1.ec103
Publikováno v:
Annales Geophysicae, Vol 32, Pp 1305-1309 (2014)
We present a refined algorithm to calculate pseudo solar indices, which enable the reproduction of a solar flare impact on the upper Earth's atmosphere for the empirical thermosphere model Jacchia-Bowman 2008. In a first step we compare the estima
Externí odkaz:
https://doaj.org/article/d8072d92914149c2aca902aa04bd849f
Publikováno v:
PLoS Genetics, Vol 12, Iss 8, p e1006198 (2016)
Hippo signaling acts as a master regulatory pathway controlling growth, proliferation, and apoptosis and also ensures that variations in proliferation do not alter organ size. How the pathway coordinates restricting proliferation with organ size cont
Externí odkaz:
https://doaj.org/article/ff9a42ba5fe3443c851058261d33de31
Autor:
Hsiu-Yu Liu, Cathie M Pfleger
Publikováno v:
PLoS ONE, Vol 8, Iss 1, p e32835 (2013)
Neurodegenerative diseases cause tremendous suffering for those afflicted and their families. Many of these diseases involve accumulation of mis-folded or aggregated proteins thought to play a causal role in disease pathology. Ubiquitinated proteins
Externí odkaz:
https://doaj.org/article/ae6c78e8a9f748dab9350c216dd7931f
Publikováno v:
PLoS ONE, Vol 8, Iss 10, p e78880 (2013)
Alcohol-mediated cancers represent more than 3.5% of cancer-related deaths, yet how alcohol promotes cancer is a major open question. Using Drosophila, we identified novel interactions between dietary ethanol and loss of tumor suppressor components o
Externí odkaz:
https://doaj.org/article/4d4102965a4e4031ae87294b4bd1f336
Autor:
Cathie M. Pfleger, Jun Wang, Lauren Friedman, Roselle Vittorino, Lindsay M. Conley, Lap Ho, Hayley C. Fivecoat, Giulio M. Pasinetti
Publikováno v:
International Journal of Alzheimer's Disease, Vol 2010 (2010)
Drosophila models of tauopathies have been developed by transgenically overexpressing the disease-associated forms of tau. In this paper we report for the first time that a recently developed Grape-Seed Polyphenolic Extract (GSPE) improves the eye ph
Externí odkaz:
https://doaj.org/article/f65eea53adae44a4998aa84e8ccff441
Autor:
Hsiu-Yu Liu, Chalita Washington, Rachel Chernet, Sivan Shahar, Cathie M. Pfleger, Yesenia Martino-Cortez, Ashley M. Rosenberg, Rewatee H. Gokhale
Publikováno v:
PLoS Genetics, Vol 16, Iss 6, p e1008715 (2020)
PLoS Genetics
PLoS Genetics
Dysregulation of the Ras oncogene in development causes developmental disorders, “Rasopathies,” whereas mutational activation or amplification of Ras in differentiated tissues causes cancer. Rabex-5 (also called RabGEF1) inhibits Ras by promoting
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::951d793f8b43b4041851918b0da1adb8
https://doi.org/10.1371/journal.pgen.1008715
https://doi.org/10.1371/journal.pgen.1008715