Výsledky vyhledávání

First in man study of EP217609, a new long-acting, neutralisable parenteral antithrombotic with a dual mechanism of action

Autor: E. Fuseau, E. Neuhart, C. Krezel, Pierre Gueret, P. L. M. van Giersbergen, S. Combe, M. Petitou

Publikováno v: European Journal of Clinical Pharmacology. 72:1041-1050

EP217609 is a parenteral antithrombotic compound combining in one molecule an indirect anti-factor Xa inhibitor, a direct thrombin active site inhibitor and a biotin moiety. The aim of the study is to investigate the safety, pharmacokinetics and phar

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f98d24b90ff1663cd7cf51659726f709
https://doi.org/10.1007/s00228-016-2077-2

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EP42675, a synthetic parenteral dual‐action anticoagulant: pharmacokinetics, pharmacodynamics, and absence of interactions with antiplatelet drugs

Autor: M. Petitou, E. Fuseau, P. L. M. van Giersbergen, E. Neuhart, C. Krezel, Pierre Gueret

Publikováno v: Journal of Thrombosis and Haemostasis. 12:24-33

Summary Background EP42675 is a first-in-class, synthetic, parenteral, anticoagulant combining in a single molecule a direct thrombin inhibitor and an indirect factor Xa(FXa) inhibitor. Objectives To investigate the safety, pharmacokinetics, and phar

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::371a93c95035cfe028eba04862e126b6
https://doi.org/10.1111/jth.12453

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Reversible biotinylated oligosaccharides: a new approach for a better management of anticoagulant therapy

Autor: P. Schaeffer, P Savi, F. Bono, Jean-Marc Herbert, M. Petitou, P. Duchaussoy, J P Hérault, L. Millet

Publikováno v: Journal of Thrombosis and Haemostasis. 6:1697-1706

Summary. Objective: In order to obtain a neutralizable antithrombotic, a chimeric molecule (SSR126517E) containing the sequence of a long-lasting antithrombin (AT)-dependent anti-factor Xa pentasaccharide, idraparinux, linked to a biotin molecule was

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::965cc9ebb0253d70fbb026808160d0db
https://doi.org/10.1111/j.1538-7836.2008.03089.x

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Biochemical and Pharmacological Properties of SANORG 34006, a Potent and Long-Acting Synthetic Pentasaccharide

Autor: A Bernat, D.G. Meuleman, C. A. A. Van Boeckel, J.M. Herbert, J. P. Herault, M Petitou, J.C. Lormeau, Peter R. Hoffmann, van Rgm Amsterdam

Publikováno v: Blood : the Journal of Hematology, 91(11), 4179-4205. American Society of Hematology

SANORG 34006 is a new sulfated pentasaccharide obtained by chemical synthesis. It is an analog of the “synthetic pentasaccharide” (SR 90107/ ORG 31540) which represents the antithrombin (AT) binding site of heparin. SANORG 34006 showed a higher a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a595b9874c2713ce116b1abf796b384b
https://doi.org/10.1182/blood.v91.11.4197

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A synthetic heparin/heparan sulfate-like decasaccharide releases lipase activity in vivo. Chemical synthesis and biological activity

Autor: Peter R. Hoffmann, Jean-Marc Herbert, A. Bernat, M. Petitou, P. Duchaussoy

Publikováno v: Bioorganic & Medicinal Chemistry Letters. 7:2067-2070

A decasaccharide mimic of the heparan sulfate fragment reported to have high affinity for lipoprotein lipase has been synthesised, and shown to release lipase activity in vivo in the rat.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::bd3a3f3a2cf174dc54286cc8231b02bd
https://doi.org/10.1016/s0960-894x(97)00361-2

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Biochemical and Pharmacological Properties of SANORG 32701

Autor: R. G. M. Van Amsterdam, J.P. He´rault, G.M.T. Vogel, D.G. Meuleman, M. Petitou, J.C. Lormeau, A. Bernat, J.M. Herbert

Publikováno v: Circulation Research. 79:590-600

SANORG 32701 is a new sulfated pentasaccharide obtained by total chemical synthesis. It is an analogue of the “synthetic pentasaccharide” (SR 90107/ORG 31540), which represents the antithrombin III (AT-III) binding site of heparin. Like SR 90107,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ecbc9071b7c42a66f674a1806028129
https://doi.org/10.1161/01.res.79.3.590

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