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Akademický článek

Conformation selection by ATP-competitive inhibitors and allosteric communication in ERK2

Autor: Jake W Anderson, David Vaisar, David N Jones, Laurel M Pegram, Guy P Vigers, Huifen Chen, John G Moffat, Natalie G Ahn

Publikováno v: eLife, Vol 12 (2024)

Activation of the extracellular signal-regulated kinase-2 (ERK2) by phosphorylation has been shown to involve changes in protein dynamics, as determined by hydrogen-deuterium exchange mass spectrometry (HDX-MS) and NMR relaxation dispersion measureme

Externí odkaz: https://doaj.org/article/089ca721611842539172a5e7837a22f2

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Akademický článek

Accidental hypothermic cardiac arrest and extracorporeal membrane oxygenation: a case report

Autor: P. Daniel Patterson, Taylor C. Hupfeld, Nia Forbes, Zach J. Blickley, Jared A. Collins, Ashley M. Pegram, Francis X. Guyette

Publikováno v: Journal of the American College of Emergency Physicians Open, Vol 1, Iss 3, Pp 158-162 (2020)

Abstract Background Accidental hypothermic cardiac arrest, an involuntary drop in core body temperature resulting in cardiopulmonary arrest, is linked to 1500 deaths annually. We highlight the challenges with the treatment of accidental hypothermic c

Externí odkaz: https://doaj.org/article/4343db397e1d472fb05acf10846db372

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Stumbling around the Bases: The American League’s Mismanagement in the Expansion Era by Andy McCue

Autor: David M. Pegram

Publikováno v: NINE: A Journal of Baseball History and Culture. 31:135-137

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::fbe0152efdcaaa3411be26672c70bcde
https://doi.org/10.1353/nin.2023.0019

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Dynamic equilibria in protein kinases

Autor: Jake W. Anderson, Laurel M. Pegram, Natalie G. Ahn

Publikováno v: Curr Opin Struct Biol

Structural changes involved in protein kinase activation and ligand binding have been determined from a wealth of X-ray crystallographic evidence. Recent solution studies using NMR, EPR, HX-MS, and fluorescence techniques have deepened this understan

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::652458d3c97344be99a61d1db22790b9
https://doi.org/10.1016/j.sbi.2021.07.006

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Corrigendum to 'Tucatinib versus placebo added to trastuzumab and capecitabine for patients with pretreated HER2D metastatic breast cancer with and without brain metastases (HER2CLIMB): final overall survival analysis'

Publikováno v: Annals of Oncology.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::63254b257b41936dde97536531dcb4ae
https://doi.org/10.1016/j.annonc.2022.12.005

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Aktualisierte Ergebnisse von Tucatinib versus Placebo in Kombination mit Trastuzumab und Capecitabin bei Patienten mit vorbehandeltem, metastasierten HER2-positiven Brustkrebs mit ZNS-Metastasen (HER2CLIMB)

Autor: R Greil, N U Lin, R K Murthy, V Abramson, C Anders, T Bachelot, P L Bedard, V Borges, D Cameron, L Carey, A J Chien, G Curigliano, M P DiGiovanna, K Gelmon, G Hortobagyi, S Hurvitz, I Krop, S Loi, S Loibl, V Mueller, M Oliveira, E Paplomata, M Pegram, D Slamon, A Zelnak, J Ramos, W Feng, E. Winer

Publikováno v: Geburtshilfe und Frauenheilkunde.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::563f2f196f17d77ddaa6794bc0350ca1
https://doi.org/10.1055/s-0042-1746156

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Accidental hypothermic cardiac arrest and extracorporeal membrane oxygenation: a case report

Autor: Taylor C. Hupfeld, P. Daniel Patterson, Nia Forbes, Francis X. Guyette, Ashley M. Pegram, Zach J. Blickley, Jared A. Collins

Publikováno v: Journal of the American College of Emergency Physicians Open
Journal of the American College of Emergency Physicians Open, Vol 1, Iss 3, Pp 158-162 (2020)

Background Accidental hypothermic cardiac arrest, an involuntary drop in core body temperature resulting in cardiopulmonary arrest, is linked to 1500 deaths annually. We highlight the challenges with the treatment of accidental hypothermic cardiac ar

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f3ba68fb3eae2121ab9e63e9822842c3
https://doi.org/10.1002/emp2.12048

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Tucatinib versus placebo added to trastuzumab and capecitabine for patients with pretreated HER2+ metastatic breast cancer with and without brain metastases (HER2CLIMB): final overall survival analysis

Publikováno v: Annals of oncology : official journal of the European Society for Medical Oncology. 33(3)

In the primary analysis of the HER2CLIMB trial, tucatinib added to trastuzumab and capecitabine significantly improved overall survival (OS) and progression-free survival (PFS) in patients with human epidermal growth factor receptor 2 positive (HER2+

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::793d247185ba5b750a20c695137800ca
https://pubmed.ncbi.nlm.nih.gov/36564285

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164P Preliminary results from a phase I/II study of BDC-1001, a novel HER2 targeting TLR7/8 immune-stimulating antibody conjugate (ISAC), in patients (pts) with advanced HER2-expressing solid tumors

Autor: M.R. Sharma, R.D. Carvajal, G.J. Hanna, Y.K. Kang, J. Lee, K.W. Lee, B.T. Li, K.N. Moore, M. Pegram, D. Rasco, A. Spira, D. Wang, B.A. Weinberg, M. Alonso, L. Fang, A. Husain, M. Kowanetz, E.A. Perez, E.I. Dumbrava

Publikováno v: Annals of Oncology. 32:S1453-S1454

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::786697f12c604e9d67827e1591cae11b
https://doi.org/10.1016/j.annonc.2021.10.183

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Akademický článek

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