Zobrazeno 1 - 10
of 13
pro vyhledávání: '"M P Vitek"'
Publikováno v:
Tsitologiia. 53(12)
One of the earliest neuropathological symptoms of Alzheimer's disease is the loss of synapses, which preceed the formation of amyloidosis and neurodegeneration. Although most cases of early-onset familial Alzheimer's disease are caused by mutations i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::db6ca8e57846ce3023bb32fbc5cb97bb
https://pubmed.ncbi.nlm.nih.gov/22359955
https://pubmed.ncbi.nlm.nih.gov/22359955
Publikováno v:
Biofizika. 55(5)
Experimental evidence has been obtained that mutations in the presenilin 1 (PS1) gene in familial Alzheimer's disease can lead to the disturbance of cell adhesion in model cell cultures. It was shown that, in L fibroblasts of mice with stable express
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::fae26973a97a638539ec6743c990f896
https://pubmed.ncbi.nlm.nih.gov/21033353
https://pubmed.ncbi.nlm.nih.gov/21033353
Publikováno v:
Biofizika. 53(6)
A comparative study of growth cone morphology in cultured embryonic neurons derived from wild type PS 1(+/+) and knockout PS 1(-/-) mice has been performed. Growth cones from wild type PS 1(+/+) mice were well spread and usually formed radially conti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::3bcce909fddb23f1ae02d879b10756c3
https://pubmed.ncbi.nlm.nih.gov/19137685
https://pubmed.ncbi.nlm.nih.gov/19137685
Publikováno v:
Biofizika. 51(5)
Most cases of familial early-onset Alzheimer's disease are caused by mutations in the presenilin 1 (PS1) gene. However, the cellular functions of PS1 are not yet completely understood. We showed that endogenous PS1 and the adhesion protein CD44 are r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::75255c3008ed9e05429fb17539442f54
https://pubmed.ncbi.nlm.nih.gov/17131822
https://pubmed.ncbi.nlm.nih.gov/17131822
Autor:
H, Matsuzaki, M, Tamatani, A, Yamaguchi, K, Namikawa, H, Kiyama, M P, Vitek, N, Mitsuda, M, Tohyama
Publikováno v:
FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 15(7)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::2048a8b0125eb7618884e9dc3b69cb5e
https://pubmed.ncbi.nlm.nih.gov/11344093
https://pubmed.ncbi.nlm.nih.gov/11344093
Autor:
J S, Jacobsen, M A, Spruyt, A M, Brown, S R, Sahasrabudhe, A J, Blume, M P, Vitek, H A, Muenkel, J, Sonnenberg-Reines
Publikováno v:
The Journal of biological chemistry. 269(11)
Amyloid precursor protein (APP) is cleaved predominantly within the beta amyloid peptide (BAP) domain to release a non-amyloidogenic amino-terminal PN2 fragment. Treatment of cells with phorbol dibutyrate, an agent which activates protein kinase C, h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::f76b8a2898899f160abbfb3730a70576
https://pubmed.ncbi.nlm.nih.gov/8132561
https://pubmed.ncbi.nlm.nih.gov/8132561
Autor:
S R, Sahasrabudhe, A M, Brown, J D, Hulmes, J S, Jacobsen, M P, Vitek, A J, Blume, J L, Sonnenberg
Publikováno v:
The Journal of biological chemistry. 268(22)
The major pathological change in Alzheimer's disease is the deposition of 39-42-amino acid beta-amyloid peptide (BAP) in the brain. Since BAP begins at the aspartate residue (Asp1, or codon 672 of the amyloid precursor protein (APP)770 transcript), t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::8aad8eba2a4fd43461710ccad6b7343d
https://pubmed.ncbi.nlm.nih.gov/8344949
https://pubmed.ncbi.nlm.nih.gov/8344949
Publikováno v:
The Journal of biological chemistry. 267(35)
Abnormal proteolytic processing of amyloid precursor protein (APP) is thought to be central to the formation and deposition of beta amyloid peptide in Alzheimer's disease. A putative "secretase" activity normally releases an amino-terminal APP fragme
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::eecfdb46a95e0628db5dbaf605067d04
https://pubmed.ncbi.nlm.nih.gov/1281162
https://pubmed.ncbi.nlm.nih.gov/1281162
Autor:
K M, Garrett, N, Saito, R S, Duman, M S, Abel, R A, Ashton, S, Fujimori, B, Beer, J F, Tallman, M P, Vitek, A J, Blume
Publikováno v:
Molecular pharmacology. 37(5)
A 1.8-kilobase (kb) cDNA clone for a beta 1 subunit of the human gamma-aminobutyric acidA (GABAA) receptor has been isolated and sequenced. The longest open reading frame of the clone, pCLL610, contains nucleotide sequence encoding a portion of the p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::53b1083e9ffd00463ad9031e4e116b4a
https://pubmed.ncbi.nlm.nih.gov/2160058
https://pubmed.ncbi.nlm.nih.gov/2160058
Autor:
U Gubler, A O Chua, A S Stern, C P Hellmann, M P Vitek, T M DeChiara, W R Benjamin, K J Collier, M Dukovich, P C Familletti
Publikováno v:
The Journal of Immunology. 136:2492-2497
Interleukin 1 (IL 1) is a polypeptide hormone produced by activated macrophages that affects many different cell types involved in immune and inflammatory responses. The cloning and expression of a murine IL 1 cDNA in Escherichia coli encoding a poly
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c82041c99e635bc4336d66466f3727c0
https://doi.org/10.4049/jimmunol.136.7.2492
https://doi.org/10.4049/jimmunol.136.7.2492