Výsledky vyhledávání - "M P Stenzel-Poore"

Somatic mutation in VH complementarity-determining region 2 and framework region 2: differential effects on antigen binding and Ig secretion

Autor: G D Wiens, K A Heldwein, M P Stenzel-Poore, M B Rittenberg

Publikováno v: The Journal of Immunology. 159:1293-1302

The extent to which somatic mutation impairs the Ig complementarity-determining region (CDR) and framework region (FRW) structure/function is not clear. Previously, we found that the VH CDR2 of the murine T15 Ab is highly sensitive to mutation; 56% (

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::bce5a1957d1ac8ce3a9515e98bc72a59
https://doi.org/10.4049/jimmunol.159.3.1293

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Deletion in HCDR3 rescues T15 antibody mutants from a secretion defect caused by mutations in HCDR2

Autor: T M Martin, C Kowalczyk, S Stevens, G D Wiens, M P Stenzel-Poore, M B Rittenberg

Publikováno v: The Journal of Immunology. 157:4341-4346

We recently described mutants of the murine anti-phosphocholine Ab T15, with changes in heavy chain complementarity determining region 2 (HCDR2) that caused loss of secretion. Surprisingly, the T15 HCDR2 mutations did not alter secretion when placed

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::272e8d33333354e24e2a998ea8559600
https://doi.org/10.4049/jimmunol.157.10.4341

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Overproduction of corticotropin-releasing factor in transgenic mice: a genetic model of anxiogenic behavior

Autor: George F. Koob, Wylie Vale, Stephen C. Heinrichs, M. P. Stenzel-Poore, Serge Rivest

Publikováno v: The Journal of Neuroscience. 14:2579-2584

Corticotropin-releasing factor (CRF) is released in response to various stressors and regulates adrenocorticotropin secretion and glucocorticoid production. In addition to its endocrine functions, CRF acts as a neuromodulator in extra-hypothalamic sy

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39b449aa30c5ecce1dbdf21fbc268d34
https://doi.org/10.1523/jneurosci.14-05-02579.1994

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Characterization of the genomic corticotropin-releasing factor (CRF) gene from Xenopus laevis: two members of the CRF family exist in amphibians

Autor: K. A. Heldwein, P. Stenzel, M. P. Stenzel-Poore, Soon Lee, Wylie Vale

Publikováno v: Molecular Endocrinology. 6:1716-1724

In mammals, the release of pituitary ACTH is stimulated by CRF. Two related peptides exist in nonmammalian vertebrates, sauvagine from frog skin and urotensin-I from the urophysis of teleost fish. Their related structures (approximately 50%) and capa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3851288c2d79da7903455ae4e7382bb8
https://doi.org/10.1210/mend.6.10.1448118

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Characterization of the genomic corticotropin-releasing factor (CRF) gene from Xenopus laevis: two members of the CRF family exist in amphibians

Autor: M. P. Stenzel-Poore

Publikováno v: Molecular Endocrinology. 6:1716-1724

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9533e40707b662476a6c6478cb6f77e4
https://doi.org/10.1210/me.6.10.1716

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Development of Cushing's syndrome in corticotropin-releasing factor transgenic mice

Autor: V A Cameron, Wylie Vale, Joan Vaughan, M. P. Stenzel-Poore, Paul E. Sawchenko

Publikováno v: Endocrinology. 130:3378-3386

CRF is released in response to various stressors and regulates ACTH secretion and glucocorticoid production. CRF overproduction has been implicated in affective disorders, such as depression and anorexia nervosa, and may lead to Cushing's syndrome. T

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e0162e8dc1eb2a9f0db9730bdceb38e1
https://doi.org/10.1210/endo.130.6.1597149

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Natural auto- and polyreactive antibodies differing from antigen-induced antibodies in the H chain CDR3

Autor: C Chen, M P Stenzel-Poore, M B Rittenberg

Publikováno v: The Journal of Immunology. 147:2359-2367

We describe three sets of natural (preimmune) polyreactive antibodies and Ag-induced antibodies that share the same VH-VL combinations. The amino acid homology in the VH and VL segments averaged 92%. These sets were found among 49 neonatal and adult

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3330522972a1a88d8b4c565c2a636153
https://doi.org/10.4049/jimmunol.147.7.2359

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Mice overexpressing CRH show reduced responsiveness in plasma corticosterone after a5-HT1A receptor challenge

Autor: M M, van Gaalen, J H M, Reul, A, Gesing, M P, Stenzel-Poore, F, Holsboer, T, Steckler

Publikováno v: Genes, brain, and behavior. 1(3)

Corticotropin-releasing hormone (CRH) overproduction and serotonergic dysfunction have both been implicated in a range of psychiatric disorders, such as anxiety and depression, and several studies have shown interactions between these two neurotransm

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::4cd805e7f8e20cc3338a282cc776db1c
https://pubmed.ncbi.nlm.nih.gov/12884973

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