Zobrazeno 1 - 10
of 16
pro vyhledávání: '"M P Leese"'
Autor:
Y T Ho, A. Purohit, Helena J. Tutill, Michael J. Reed, Simon P. Newman, Paul A. Foster, M P Leese, Joanna M. Day, Barry V. L. Potter
Publikováno v:
British Journal of Cancer
The anti-proliferative and anti-angiogenic properties of the endogenous oestrogen metabolite, 2-methoxyoestradiol (2-MeOE2), are enhanced in a series of sulphamoylated derivatives of 2-MeOE2. To investigate possible mechanisms of resistance to these
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ac84982bd2533d2cde737d922ac5616
https://doi.org/10.1038/sj.bjc.6604873
https://doi.org/10.1038/sj.bjc.6604873
Autor:
A. Purohit, Sarah Louise Claire Tagg, Michael J. Reed, M P Leese, Simon P. Newman, Barry V. L. Potter, Paul A. Foster
Publikováno v:
British Journal of Cancer
Drug combination therapy is a key strategy to improve treatment efficacy and survival of cancer patients. In this study the effects of combining 2-methoxyoestradiol-3,17-O,O-bis-sulphamate (STX140), a microtubule disruptor, with 2-deoxy-D-glucose (2D
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c39bb47c297a0de0946f2f17ae53d75d
https://doi.org/10.1038/sj.bjc.6604752
https://doi.org/10.1038/sj.bjc.6604752
Autor:
Barry V. L. Potter, Michael F.C. Parsons, A. Purohit, Paul A. Foster, Surinder K. Chander, Michael J. Reed, M P Leese, Simon P. Newman, R Jhalli
Publikováno v:
British Journal of Cancer
The steroidal-based drug 2-ethyloestradiol-3,17-O,O-bis-sulphamate (STX243) has been developed as a potent antiangiogenic and antitumour compound. The objective of this study was to ascertain whether STX243 is more active in vivo than the clinically
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9bd6074d0604292a60808d1e926fb6de
https://doi.org/10.1038/sj.bjc.6604707
https://doi.org/10.1038/sj.bjc.6604707
Autor:
Paul A. Foster, Simon P. Newman, Joanna M. Day, Bindumalini Raobaikady, Michael J. Reed, Y T Ho, Barry V. L. Potter, M P Leese, Philip G. Kasprzyk, A. Purohit
Publikováno v:
British Journal of Cancer
Therapies for hormone-independent prostate and breast cancer are limited, with the effectiveness of the taxanes compromised by toxicity, lack of oral bioavailability and drug resistance. This study aims to identify and characterise new microtubule di
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb17d58f914856b2c9f6aa8749bec6e9
http://europepmc.org/articles/PMC2360283
http://europepmc.org/articles/PMC2360283
Publikováno v:
The Journal of Steroid Biochemistry and Molecular Biology. 94:167-172
Synthesis of oestrone from androstenedione within tumours, by the aromatase enzyme complex, is an important source of oestrogen that is available to support the growth of hormone-dependent breast tumours. In view of the central role that the aromatas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4fb088ef3037cca901c34b5110408c54
https://doi.org/10.1016/j.jsbmb.2005.01.015
https://doi.org/10.1016/j.jsbmb.2005.01.015
Autor:
Graham Packham, M P Leese, A. Purohit, Michael J. Reed, Amalia Mouzakiti, Barry V. L. Potter, L. Wood
Publikováno v:
Apoptosis. 9:323-332
2-Methoxyoestradiol (2-MeOE2) is an endogenous oestrogen metabolite which inhibits tubulin polymerisation and has anti-tumour and anti-angiogenic activity. 2-MeOE2 induces apoptosis in a wide range of cancer cell types and has recently been demonstra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c27183b42cc3165db6a1bbbbe4cf0e1
https://doi.org/10.1023/b:appt.0000025809.80684.bd
https://doi.org/10.1023/b:appt.0000025809.80684.bd
Autor:
Atul Purohit, Christopher R. Ireson, Surinder K. Chander, Simon P. Newman, B V L Potter, D. C. Parish, S Perera, A C Smith, Michael J. Reed, M P Leese
Publikováno v:
British Journal of Cancer
2-Methoxyoestradiol (2-MeOE2) is an endogenous oestrogen metabolite that inhibits the proliferation of cancer cells in vitro, and it is also antiangiogenic. In vivo 2-MeOE2, when administered at relatively high doses, inhibits the growth of tumours d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::53471e207db94c78cbeb0a9c261cb136
https://doi.org/10.1038/sj.bjc.6601591
https://doi.org/10.1038/sj.bjc.6601591
Autor:
James J. Robinson, Simon P. Newman, L W L Woo, Y T Ho, Nigel Vicker, Dharshini Ganeshapillai, A. Purohit, Michael J. Reed, Barry V. L. Potter, M P Leese
Publikováno v:
Biochemical and Biophysical Research Communications. 305:909-914
Carbonic anhydrases (CAs) are expressed by many solid tumours where they may act to confer a growth advantage on malignant tissues. In this study we have examined the ability of a series of steroidal and non-steroidal sulphamates (originally develope
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f9991b31c34bd268fb51f1998e711f32
https://doi.org/10.1016/s0006-291x(03)00865-9
https://doi.org/10.1016/s0006-291x(03)00865-9
Autor:
Klaus Hellgardt, Jonathan M. J. Williams, Amin R. Mirza, M P Leese, Michael S. Anson, David F. Thompson, and Louise Tonks
Publikováno v:
Organic Process Research & Development. 2:325-331
Heck reactions using sulphonated triphenylphosphine palladium complexes have been carried out using a supported liquid-phase catalysis system in a batch reactor. The catalyst complex is held in solution in a polar, hydrophilic film supported upon por
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b5fdf6491605b2e5167ad157d7ce32de
https://doi.org/10.1021/op980030a
https://doi.org/10.1021/op980030a
Autor:
Simon P. Newman, Surinder K. Chander, Barry V. L. Potter, A. Purohit, Toshiaki Utsumi, M P Leese, Michael J. Reed, K. Gaukroger
Publikováno v:
The Journal of steroid biochemistry and molecular biology. 94(1-3)
2-Methoxyoestrogen sulphamates are a new class of compounds, which inhibit breast cancer cell proliferation and are also potent inhibitors of steroid sulphatase (STS) activity. In the present study, we have used two cell proliferation assays (MTS and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::69f5eff59869977c66b7537647d6531c
https://pubmed.ncbi.nlm.nih.gov/15862969
https://pubmed.ncbi.nlm.nih.gov/15862969