Zobrazeno 1 - 10
of 10
pro vyhledávání: '"M P Deonarain"'
Autor:
Julie Richards, R Darbha, Dianne L. Newton, Bang K. Vu, Xinhua Ji, M. P. Deonarain, N S Courtenay-Luck, Juergen Krauss, Michaela A. E. Arndt, Susanna M. Rybak, Z Zhu, V Choudhry
Publikováno v:
British Journal of Cancer
Anti-MUC1 single-chain Fv (scFv) fragments generated from the humanised antibody huHMFG1 had adequate antigen-binding properties but very poor stability irrespective of the applied linker or domain orientation. Mutagenesis of heavy-chain framework re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28165432427a4c7a35f4ace546594fed
https://doi.org/10.1038/sj.bjc.6601759
https://doi.org/10.1038/sj.bjc.6601759
Autor:
A. A. Epenetos, M. P. Deonarain
Publikováno v:
British Journal of Cancer
Bovine seminal ribonuclease (BSRNase) is an unusual member of the ribonuclease superfamily, because of its remarkable anti-tumour and immunosuppressive properties. We describe here the construction, expression, purification and characterization of a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::246c7e6db082008fcddfd484f96bf176
http://europepmc.org/articles/PMC2149916
http://europepmc.org/articles/PMC2149916
Autor:
A. A. Epenetos, M. P. Deonarain
Publikováno v:
British Journal of Cancer
Enzymes which traditionally have played no role in cell-directed cytotoxicity are finding their way into schemes for prodrug activation and immunotoxins owing to such useful enzymatic activity. Alkaline phosphatase, carboxypeptidases, beta-glucosidas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26438fe2158ae119ba85ae2f4accbad6
https://doi.org/10.1038/bjc.1994.400
https://doi.org/10.1038/bjc.1994.400
Publikováno v:
Biotechnology letters. 32(5)
With the advent of antibody fragments and alternative binding scaffolds, that are devoid of Fc-regions, strategies to increase the half-life of small proteins are becoming increasingly important. Currently, the established method is chemical PEGylati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::76654f531ef7fbb10082e0196aa7658c
https://pubmed.ncbi.nlm.nih.gov/20131077
https://pubmed.ncbi.nlm.nih.gov/20131077
Publikováno v:
International journal of cancer. 86(4)
A number of mammalian proteins with suitable biological activities have been considered for use in targeted tumour therapy. Deoxyribonuclease-I (DNase-I), an endonuclease that degrades double-stranded DNA, represents an attractive candidate for tumou
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::42e8652b870cd3ad26b204c17a85b8fd
https://pubmed.ncbi.nlm.nih.gov/10797272
https://pubmed.ncbi.nlm.nih.gov/10797272
Publikováno v:
Gene therapy. 2(4)
For many years, antibodies have been examined as means to deliver cytotoxic proteins to kill target cells (immunotoxins). More recently, there have been studies on enzymes that convert prodrugs to active drugs to kill target cells. The advances in ge
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::3a084168691ca3e2b444d15d9b631004
https://pubmed.ncbi.nlm.nih.gov/7552983
https://pubmed.ncbi.nlm.nih.gov/7552983
Publikováno v:
Gene therapy. 2(3)
The recent finding that inoculation with plasmids encoding a variety of proteins leads to T cell and antibody responses in vivo against these proteins provides a novel means of active specific immunisation by plasmid vaccination. The demonstration th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::02a8f4393f343155869bf1c569f2f0c4
https://pubmed.ncbi.nlm.nih.gov/7614247
https://pubmed.ncbi.nlm.nih.gov/7614247
Autor:
M A Butt, H Pye, R J Haidry, D Oukrif, M Rashid, M R Banks, M P Deonarain, M R Novelli, L B Lovat
Publikováno v:
Gut. 61:A301.1-A301
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ae362d51c12fa9bab4700f0fcd0c039b
https://doi.org/10.1136/gutjnl-2012-302514d.11
https://doi.org/10.1136/gutjnl-2012-302514d.11
Autor:
M A Butt, R J Haidry, D Oukrif, H Pye, I Stamati, G Yahioglu, M Rodriguez-Justo, M R Banks, M P Deonarain, M R Novelli, L B Lovat
Publikováno v:
Gut. 61:A302.3-A303
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::64a00a2a29c6736d8cffacddeb62ab4b
https://doi.org/10.1136/gutjnl-2012-302514d.15
https://doi.org/10.1136/gutjnl-2012-302514d.15
Autor:
A. Constantinou, A. A. Epenetos, D. Hreczuk-Hirst, S. Jain, M. Wright, K. A. Chester, M. P. Deonarain
Publikováno v:
Bioconjugate Chemistry; May2009, Vol. 20 Issue 5, p924-931, 8p