Výsledky vyhledávání - "M P, Vierboom"

High steady-state levels of p53 are not a prerequisite for tumor eradication by wild-type p53-specific cytotoxic T lymphocytes

Autor: M P, Vierboom, S, Zwaveling, Bos GMJ, M, Ooms, G M, Krietemeijer, C J, Melief, R, Offringa

Publikováno v: Cancer research. 60(19)

CTLs specific to p53 were previously shown to efficiently eradicate p53-overexpressing tumor cells in vitro as well as in vivo. In this report, we demonstrate that these CTLs can also eliminate tumors that display moderate or even low levels of p53.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::f36304eb1a2fc03c6e7a84cfeac3a9d9
https://pubmed.ncbi.nlm.nih.gov/11034095

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Cyclophosphamide enhances anti-tumor effect of wild-type p53-specific CTL

Autor: M P, Vierboom, G M, Bos, M, Ooms, R, Offringa, C J, Melief

Publikováno v: International journal of cancer. 87(2)

The tumor suppressor protein p53 is overexpressed in up to 50% of all human malignancies, both in solid tumors as well as hematological malignancies, and is therefore an attractive target for immunotherapy. We have recently shown that cytotoxic T lym

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::4b748e7793cc7ca97fdc59e8cbeb0b1a
https://pubmed.ncbi.nlm.nih.gov/10861484

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Cryptic open reading frames in plasmid vector backbone sequences can provide highly immunogenic cytotoxic T-lymphocyte epitopes

Autor: T, van Hall, N E, van de Rhee, S P, Schoenberger, M P, Vierboom, F A, Verreck, C J, Melief, R, Offringa

Publikováno v: Cancer research. 58(14)

Murine tumor cells obtained through transfection of expression plasmids carrying activated cellular and/or viral oncogenes constitute formidable tools for immunological tumor research. As reported previously, mouse embryo cells of C57BL/6 origin, tra

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::839af060e776c364ad70f4a0b0cf9d3d
https://pubmed.ncbi.nlm.nih.gov/9679975

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Immunization with human papillomavirus type 16 (HPV16) oncoprotein-loaded dendritic cells as well as protein in adjuvant induces MHC class I-restricted protection to HPV16-induced tumor cells

Autor: M L, De Bruijn, D H, Schuurhuis, M P, Vierboom, H, Vermeulen, K A, de Cock, M E, Ooms, M E, Ressing, M, Toebes, K L, Franken, J W, Drijfhout, T H, Ottenhoff, R, Offringa, C J, Melief

Publikováno v: Cancer research. 58(4)

Human papillomavirus (HPV) E6 and E7 oncoproteins are attractive targets for T-cell-based immunotherapy of cervical cancer. In this study, we demonstrate that dendritic cells (DCs) pulsed with HPV16 E7 protein are not only recognized in vitro by E7-s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::8b452f3d293837bae7460f612ea7c454
https://pubmed.ncbi.nlm.nih.gov/9485027

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Characterization of cytotoxic T lymphocyte epitopes of a self-protein, p53, and a non-self-protein, influenza matrix: relationship between major histocompatibility complex peptide binding affinity and immune responsiveness to peptides

Autor: H W, Nijman, J G, Houbiers, S H, van der Burg, M P, Vierboom, P, Kenemans, W M, Kast, C J, Melief

Publikováno v: Journal of immunotherapy with emphasis on tumor immunology : official journal of the Society for Biological Therapy. 14(2)

We previously described a motif prediction of major histocompatibility complex allele-specific peptides and an in vitro assay for actual measurement of peptide binding to human leukocyte antigen HLA-A2.1 molecules. Using this method we have identifie

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::99615062d50374cd107a469609a7b926
https://pubmed.ncbi.nlm.nih.gov/7506574

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