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Autor:
Bernhard Ryffel, O. Rutschi, L. Fauconnier, M. P. Rudolf, Thomas Secher, Agata Szade, S. C. Fas
Publikováno v:
Journal of Antimicrobial Chemotherapy. 66:1100-1109
To investigate the in vivo efficacy in a murine pulmonary infection model of panobacumab (KBPA101), a human IgM monoclonal antibody directed against the O-polysaccharide moiety of Pseudomonas aeruginosa serotype O11, and to describe the anti-inflamma
Publikováno v:
The Journal of Immunology. 157:5646-5652
Anti-IgE mAbs have always been used to trigger mediator release from basophils or mast cells. Now nonanaphylactogenic anti-human IgE Abs are in clinical evaluation as a therapeutic agent against atopic disease. We have found a mAb that is nonanaphyla
Publikováno v:
Methods in molecular medicine. 61
In the last decade, many antigens expressed by tumors and recognized by the immune system have been identified. Melanoma was among the first tumors found to express such tumor-associated antigens, and, therefore, melanoma is currently one of the best
Publikováno v:
Clinical cancer research : an official journal of the American Association for Cancer Research. 7
Human Papillomaviruses (HPVs) are sexually transmitted pathogens, which are implicated in the etiology of cervical cancer. The early proteins E6 and E7 of HPV have transforming capacity and interfere with the cell cycle control of infected host cells
Publikováno v:
Current opinion in molecular therapeutics. 1(1)
Papillomavirus virus-like particles (VLPs) are empty, non-replicative, non-infectious particles that retain conformationally correct epitopes for the generation of antibody responses to the viral capsid proteins. Chimeric human papillomavirus (HPV) v
Autor:
D M, Da Silva, G L, Eiben, S C, Fausch, M T, Wakabayashi, M P, Rudolf, M P, Velders, W M, Kast
Publikováno v:
Journal of cellular physiology. 186(2)
Certain human cancers are linked to infection by oncogenic viruses that are able to cause transformation of the normal host cell into a cancerous cell. Human papillomavirus (HPV) DNA and expression of viral transforming proteins are found in virtuall
Publikováno v:
European journal of immunology. 30(1)
An essential requirement for oral vaccines is the ability to survive the harsh environment of the stomach in an antigenically intact form. As bacteriophages are adapted to this environment we used epitope-displaying M13 bacteriophages as carriers for
Publikováno v:
European journal of immunology. 29(9)
Antigen-specific human IgE is in short supply. Thus, we sought to determine the yet unknown specificity of a widely available human IgE, namely the myeloma cell line U266-derived IgE-ND. For this purpose highly specific peptides able to mimic the put
Publikováno v:
International archives of allergy and immunology. 118(2-4)