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Akademický článek

Circulating HBsAg-specific B cells are partially rescued in chronically HBV-infected patients with functional cure

Autor: Shuqin Gu, Libo Tang, Ling Guo, Chunxiu Zhong, Xin Fu, Guofu Ye, Shihong Zhong, Xiaoyi Li, Chunhua Wen, Yang Zhou, Jinling Wei, Haitao Chen, Nikolai Novikov, Simon P. Fletcher, M. Anthony Moody, Jinlin Hou, Yongyin Li

Publikováno v: Emerging Microbes and Infections, Vol 13, Iss 1 (2024)

It is well established that humoral immunity targeting hepatitis B virus surface antigen (HBsAg) plays a critical role in viral clearance and clinical cure. However, the functional changes in HBsAg-specific B cells before and after achieving function

Externí odkaz: https://doaj.org/article/f7d734b3c4d9471c9d5b1528dfa1a03e

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Akademický článek

Conjugation of HIV-1 envelope to hepatitis B surface antigen alters vaccine responses in rhesus macaques

Publikováno v: npj Vaccines, Vol 8, Iss 1, Pp 1-15 (2023)

Abstract An effective HIV-1 vaccine remains a critical unmet need for ending the AIDS epidemic. Vaccine trials conducted to date have suggested the need to increase the durability and functionality of vaccine-elicited antibodies to improve efficacy.

Externí odkaz: https://doaj.org/article/47723f7571494d1382df246f734a90c6

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Akademický článek

Treponema pallidum genetic diversity and its implications for targeted vaccine development: A cross-sectional study of early syphilis cases in Southwestern Colombia.

Publikováno v: PLoS ONE, Vol 19, Iss 7, p e0307600 (2024)

BackgroundVenereal syphilis, caused by the spirochete Treponema pallidum subsp. pallidum (TPA), is surging worldwide, underscoring the need for a vaccine with global efficacy. Vaccine development requires an understanding of syphilis epidemiology and

Externí odkaz: https://doaj.org/article/580798f8696f4cdb9290c1c44609ff3e

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Akademický článek

Use of Epivolve phage display to generate a monoclonal antibody with opsonic activity directed against a subdominant epitope on extracellular loop 4 of Treponema pallidum BamA (TP0326)

Autor: Mary R. Ferguson, Kristina N. Delgado, Shannon McBride, Isabel C. Orbe, Carson J. La Vake, Melissa J. Caimano, Qiana Mendez, Trevor F. Moraes, Anthony B. Schryvers, M. Anthony Moody, Justin D. Radolf, Michael P. Weiner, Kelly L. Hawley

Publikováno v: Frontiers in Immunology, Vol 14 (2023)

IntroductionSyphilis, a sexually transmitted infection caused by the spirochete Treponema pallidum (Tp), is resurging globally. Tp’s repertoire of outer membrane proteins (OMPs) includes BamA (β-barrel assembly machinery subunit A/TP0326), a bipar

Externí odkaz: https://doaj.org/article/269f6fb6d31f482c8031d99450697c02

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Akademický článek

H3N2 influenza hemagglutination inhibition method qualification with data driven statistical methods for human clinical trials

Autor: Sheetal Sawant, Sarah Anne Gurley, R. Glenn Overman, Angelina Sharak, Sarah V. Mudrak, Thomas Oguin, Gregory D. Sempowski, Marcella Sarzotti-Kelsoe, Emmanuel B. Walter, Hang Xie, Marcela F. Pasetti, M. Anthony Moody, Georgia D. Tomaras

Publikováno v: Frontiers in Immunology, Vol 14 (2023)

IntroductionHemagglutination inhibition (HAI) antibody titers to seasonal influenza strains are important surrogates for vaccine-elicited protection. However, HAI assays can be variable across labs, with low sensitivity across diverse viruses due to

Externí odkaz: https://doaj.org/article/fb09ca27495b4849a863aa424e95e29c

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Akademický článek

Neonatal SHIV infection in rhesus macaques elicited heterologous HIV-1-neutralizing antibodies

Publikováno v: Cell Reports, Vol 42, Iss 3, Pp 112255- (2023)

Summary: Infants and children infected with human immunodeficiency virus (HIV)-1 have been shown to develop neutralizing antibodies (nAbs) against heterologous HIV-1 strains, characteristic of broadly nAbs (bnAbs). Thus, having a neonatal model for t

Externí odkaz: https://doaj.org/article/7dce7418af584710aa80977788fdbcd6

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Akademický článek

Case Report: Nontuberculous mycobacterial infections in children with complete DiGeorge anomaly

Autor: Elizabeth Daly Hicks, Noah O. Agada, Tyler R. Yates, Matthew S. Kelly, Jonathan S. Tam, Ronald M. Ferdman, Louis R. Dibernardo, John F. Madden, M. Anthony Moody, Mary Louise Markert

Publikováno v: Frontiers in Immunology, Vol 14 (2023)

Children with complete DiGeorge anomaly (cDGA) have congenital athymia, resulting in severe T cell immunodeficiency and susceptibility to a broad range of infections. We report the clinical course, immunologic phenotypes, treatment, and outcomes of t

Externí odkaz: https://doaj.org/article/e371aef595714601ae24b1d9edcb83d4

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Akademický článek

Infant Antibody Repertoires during the First Two Years of Influenza Vaccination

Autor: Masayuki Kuraoka, Nicholas C. Curtis, Akiko Watanabe, Hidetaka Tanno, Seungmin Shin, Kevin Ye, Elizabeth Macdonald, Olivia Lavidor, Susan Kong, Tarra Von Holle, Ian Windsor, Gregory C. Ippolito, George Georgiou, Emmanuel B. Walter, Garnett Kelsoe, Stephen C. Harrison, M. Anthony Moody, Goran Bajic, Jiwon Lee

Publikováno v: mBio, Vol 13, Iss 6 (2022)

ABSTRACT The first encounter with influenza virus biases later immune responses. This “immune imprinting,” formerly from infection within a few years of birth, is in the United States now largely from immunization with a quadrivalent, split vacci

Externí odkaz: https://doaj.org/article/78cc8ec4cbe84dca80713d6f5794546a

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