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Selective in vitro and in vivo binding of [(125)I]ADAM to serotonin transporters in rat brain

Autor: S R, Choi, C, Hou, S, Oya, M, Mu, M P, Kung, M, Siciliano, P D, Acton, H F, Kung

Publikováno v: Synapse (New York, N.Y.). 38(4)

An improved iodinated tracer, ADAM (2-((2-((dimethylamino)methyl)- phenyl)thio)-5-iodophenylamine) for imaging serotonin transporters (SERT) with single photon emission computerized tomography (SPECT), was prepared and characterized. Scatchard analys

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::c032295b0d8e50d03d36a23396725f06
https://pubmed.ncbi.nlm.nih.gov/11044887

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Simultaneous SPECT studies of pre- and postsynaptic dopamine binding sites in baboons

Autor: S H, Dresel, M P, Kung, X F, Huang, K, Plössl, C, Hou, S K, Meegalla, G, Patselas, M, Mu, J R, Saffer, H F, Kung

Publikováno v: Journal of nuclear medicine : official publication, Society of Nuclear Medicine. 40(4)

The central nervous system dopamine transporters (DATs) and dopamine D2/D3 receptors are implicated in a variety of neurological disorders. Both sites are also targets for drug treatment. With the successful development of [99mTc]TRODAT-1, single-iso

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::1849e3ec8b287b0882e9b93acaca2b7e
https://pubmed.ncbi.nlm.nih.gov/10210226

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Isoindol-1-one analogues of 4-(2'-methoxyphenyl)-1-[2'-[N-(2'-pyridyl)-p-iodobenzamido]ethyl]pipera zine (p-MPPI) as 5-HT1A receptor ligands

Autor: Z-P. Zhuang, Mu Mu, Hank F. Kung, M.-P. Kung

Publikováno v: Journal of medicinal chemistry. 41(2)

In developing radioiodinated antagonists for in vivo imaging of 5-HT1A receptors with SPECT, a series of new arylpiperazine benzamido derivatives, including 4-(2'-methoxyphenyl)-1-[2'-[N-(2"-pyridyl)-p-iodobenzamido]ethyl]p iperazine (p-MPPI, 31) (Kd

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd7b62e646dd1683765eb58e123a828b
https://pubmed.ncbi.nlm.nih.gov/9457239

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Characterization of [125I]S(-)5-OH-PIPAT binding to dopamine D2-like receptors expressed in cell lines

Autor: J M, Vessotskie, M P, Kung, S, Chumpradit, H F, Kung

Publikováno v: Neuropharmacology. 36(7)

Recently, [125I]S(-)5-OH-PIPAT [5-hydroxy-2-(N-n-propyl-N-3'-iodo-2'-propenyl)aminotetralin], a derivative of S(-)5-OH-DPAT (5-hydroxy-N,N-di-n-propyl-aminotetralin), was reported to be a better radioiodinated dopamine D2-like receptor ligand than th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::340c48afa252cc6aa8d807f991025653
https://pubmed.ncbi.nlm.nih.gov/9257944

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P-[18F]-MPPF: a potential radioligand for PET studies of 5-HT1A receptors in humans

Autor: C Y, Shiue, G G, Shiue, P D, Mozley, M P, Kung, Z P, Zhuang, H J, Kim, H F, Kung

Publikováno v: Synapse (New York, N.Y.). 25(2)

The purpose of this study was to develop a radiopharmaceutical that could be used to selectively image 5-HT1A receptors with positron emission tomography (PET). No-carrier-added 4-(2'-methoxyphenyl)-1-[2'-(N-2"-pyridinyl)-p-[18F] fluorobenzamido]ethy

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::dc8e0fe3ed3fa267fdc51c9b09d6d0bb
https://pubmed.ncbi.nlm.nih.gov/9021895

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