Zobrazeno 1 - 10
of 22
pro vyhledávání: '"M P, Jamieson"'
Autor:
Tet Woo Lee, Dean C. Singleton, Julia K. Harms, Man Lu, Sarah P. McManaway, Amy Lai, Moana Tercel, Frederik B. Pruijn, Andrew M. J. Macann, Francis W. Hunter, William R. Wilson, Stephen M. F. Jamieson
Publikováno v:
Molecular Oncology, Vol 18, Iss 8, Pp 1885-1903 (2024)
Tumour hypoxia promotes poor patient outcomes, with particularly strong evidence for head and neck squamous cell carcinoma (HNSCC). To effectively target hypoxia, therapies require selection biomarkers and preclinical models that can accurately model
Externí odkaz:
https://doaj.org/article/8463ca23a4994262a7d8bf8b809ac374
Autor:
Lydia P. Liew, Avik Shome, Way W. Wong, Cho R. Hong, Kevin O. Hicks, Stephen M. F. Jamieson, Michael P. Hay
Publikováno v:
Molecules, Vol 28, Iss 11, p 4457 (2023)
The role of hypoxic tumour cells in resistance to radiotherapy, and in suppression of immune response, continues to endorse tumour hypoxia as a bona fide, yet largely untapped, drug target. Radiotherapy innovations such as stereotactic body radiother
Externí odkaz:
https://doaj.org/article/4764aa3eb15346ccaeda89c53387ec2a
Autor:
Lewis P. M. Green, Tasha R. Steel, Mie Riisom, Muhammad Hanif, Tilo Söhnel, Stephen M. F. Jamieson, L. James Wright, James D. Crowley, Christian G. Hartinger
Publikováno v:
Frontiers in Chemistry, Vol 9 (2021)
Multimetallic complexes have been shown in several examples to possess greater anticancer activity than their monometallic counterparts. The increased activity has been attributed to altered modes of action. We herein report the synthesis of a series
Externí odkaz:
https://doaj.org/article/a21f05c5e4db47739cd389b575891a47
Autor:
Lynn S. Lisboa, Mie Riisom, Roan A. S. Vasdev, Stephen M. F. Jamieson, L. James Wright, Christian G. Hartinger, James D. Crowley
Publikováno v:
Frontiers in Chemistry, Vol 9 (2021)
Externí odkaz:
https://doaj.org/article/3bb6755fd37f49ab909b2c9bc734637c
Autor:
Lynn S. Lisboa, Mie Riisom, Roan A. S. Vasdev, Stephen M. F. Jamieson, L. James Wright, Christian G. Hartinger, James D. Crowley
Publikováno v:
Frontiers in Chemistry, Vol 9 (2021)
Two new di(2,2′-bipyridine) ligands, 2,6-bis([2,2′-bipyridin]-5-ylethynyl)pyridine (L1) and bis(4-([2,2′-bipyridin]-5-ylethynyl)phenyl)methane (L2) were synthesized and used to generate two metallosupramolecular [Fe2(L)3](BF4)4 cylinders. The l
Externí odkaz:
https://doaj.org/article/c04d97b14e8d46c7aa5570d386a6ba85
Autor:
Jahanzaib Arshad, Kelvin K. H. Tong, Sanam Movassaghi, Tilo Söhnel, Stephen M. F. Jamieson, Muhammad Hanif, Christian G. Hartinger
Publikováno v:
Molecules, Vol 26, Iss 4, p 833 (2021)
RuII(cym)Cl (cym = η6-p-cymene) complexes of pyridinecarbothioamides have shown potential for development as orally active anticancer metallodrugs, underlined by their high selectivity towards plectin as the molecular target. In order to investigate
Externí odkaz:
https://doaj.org/article/0c29b966a1e74fa9bb1d5c7c6222e631
Autor:
Md. Salman Shakil, Shahida Parveen, Zohaib Rana, Fearghal Walsh, Sanam Movassaghi, Tilo Söhnel, Mayur Azam, Muhammad Ashraf Shaheen, Stephen M. F. Jamieson, Muhammad Hanif, Rhonda J. Rosengren, Christian G. Hartinger
Publikováno v:
Biomedicines, Vol 9, Iss 2, p 123 (2021)
Hydroxypyr(id)ones are a pharmaceutically important class of compounds that have shown potential in diverse areas of drug discovery. We investigated the 3-hydroxy-4-pyridones 1a–1c and 3-hydroxy-4-thiopyridones 1d–1f as well as their Ru(η6-p-cym
Externí odkaz:
https://doaj.org/article/3583fd1cf73c490da2a40080e038b220
Autor:
Kelvin K. H. Tong, Muhammad Hanif, James H. Lovett, Katja Hummitzsch, Hugh H. Harris, Tilo Söhnel, Stephen M. F. Jamieson, Christian G. Hartinger
Publikováno v:
Molecules, Vol 25, Iss 16, p 3661 (2020)
Thiones have been investigated as ligands in metal complexes with catalytic and biological activity. We report the synthesis, characterization, and biological evaluation of a series of MII/III complexes of the general formulae [MII(cym)(L)Cl]X (cym =
Externí odkaz:
https://doaj.org/article/166377e9d24f47daa7cd997320496ee8
Autor:
Melanie eSweetlove, Emma eWrightson, Sharada eKolekar, Gordon W. Rewcastle, Bruce C. Baguley, Peter R. Shepherd, Stephen M. F. Jamieson
Publikováno v:
Frontiers in Oncology, Vol 5 (2015)
BRAF and MEK inhibitors have improved outcomes for patients with BRAF-mutant melanoma, but their efficacy is limited by both intrinsic and acquired resistance. Activation of the PI3K pathway can mediate resistance to these agents, providing a strong
Externí odkaz:
https://doaj.org/article/1641ec95a3114884a208b73af6af7e24
Autor:
Yarong Diana eYin, Melissa eFu, Darby G. Brooke, Daniel M. Heinrich, William A. Denny, Stephen M. F. Jamieson
Publikováno v:
Frontiers in Oncology, Vol 4 (2014)
AKR1C3 is a novel therapeutic target in castration-resistant prostate cancer (CRPC) and ER-positive breast cancer because of its ability to produce testosterone and 17β-estradiol intratumorally, thus promoting nuclear receptor signaling and tumor pr
Externí odkaz:
https://doaj.org/article/4700973f5fcf47adaf2400d13034aa45