Zobrazeno 1 - 10
of 37
pro vyhledávání: '"M P, Holsapple"'
Publikováno v:
Environmental Science & Technology. 36:4905-4911
Animal studies have indicated that the oral bioavailability of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in environmentally contaminated soil could range from 0.5 to 60%. To estimate the oral bioavailability of TCDD, and the 16 other 2,3,7,8-substit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c49a8628ddd0bca03ae0435d88855da9
https://doi.org/10.1021/es020636l
https://doi.org/10.1021/es020636l
Autor:
M P Holsapple
Publikováno v:
Human & Experimental Toxicology. 21:473-478
A workshop entitled ‘Developmental Immunotoxicology and Risk Assessment’ was held on 12–13 June 2001, in Washington, DC. The workshop was organized jointly by the Immunotoxicology Technical Committee (ITC) of the International Life Sciences Ins
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f0dd62171d5402be94743c31bb0f247f
https://doi.org/10.1191/0960327102ht284oa
https://doi.org/10.1191/0960327102ht284oa
Autor:
M. P. Holsapple, Scott T. Retterer
A Cooperative Research and Development Agreement (CRADA) was established between Battelle Memorial Institute (BMI), Pacific Northwest National Laboratory (PNNL), Oak Ridge National Laboratory (ORNL), Brookhaven National Laboratory (BNL), Lawrence Liv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::17794b123601ca8071263931db30d6d8
https://doi.org/10.2172/1105981
https://doi.org/10.2172/1105981
Autor:
Scott W. Burchiel, Jeffrey A. Ledbetter, N. E. Kaminski, J. G. Karras, Gary L. Schieven, M. P. Holsapple, D. R. Davila, A. R. Schatz
Publikováno v:
Annual Review of Pharmacology and Toxicology. 36:131-159
Changes in immunocompetence following chemical exposure have been established for a wide variety of unrelated agents. For the vast majority of immunotoxic compounds thus far identified, disruption of normal immune function is clearly mediated through
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06bd6492ecbe324f87da5c0f0e1f0620
https://doi.org/10.1146/annurev.pa.36.040196.001023
https://doi.org/10.1146/annurev.pa.36.040196.001023
Publikováno v:
Immunopharmacology. 19:47-58
Various immunological assays have been applied by our laboratory in an attempt to assess the role of the T-cell in the TCDD-induced suppression of the antibody response by murine B6C3F1 splenic lymphocytes. Animals were treated in vivo (via gavage) w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7459e3188e93f9c5fae2fc11ce74adeb
https://doi.org/10.1016/0162-3109(90)90026-b
https://doi.org/10.1016/0162-3109(90)90026-b
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 295(2)
The B-cell, a major cellular component of humoral immunity, has been identified as a sensitive target of 2,3,7, 8-tetrachlorodibenzo-p-dioxin (TCDD). The actual molecular mechanism responsible for the immunotoxic effects produced by TCDD is unclear;
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::7bfef56982fc99d153078bd538fa1743
https://pubmed.ncbi.nlm.nih.gov/11046109
https://pubmed.ncbi.nlm.nih.gov/11046109
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 287(3)
These studies characterized the profile of AhR and ARNT expression in primary splenocytes and purified splenic B cells after cellular activation with lipopolysaccharide (LPS). LPS treatment of mouse splenocytes markedly increased the magnitude of bot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::799fdb5a8ed6087009511566463b6538
https://pubmed.ncbi.nlm.nih.gov/9864300
https://pubmed.ncbi.nlm.nih.gov/9864300
Publikováno v:
Advances in experimental medicine and biology. 437
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::b5e2a15d4148ff99c1d8ee783be584e3
https://pubmed.ncbi.nlm.nih.gov/9666271
https://pubmed.ncbi.nlm.nih.gov/9666271
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 280(1)
A model has been developed in which acute cocaine administration results in an enhanced T-dependent antibody response to sheep erythrocytes. This enhancement occurs when cocaine (30 mg/kg, twice in 1 day) is administered 1 or 2 days before sensitizat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::5cb58484a584ab49741f51756b1fd3a3
https://pubmed.ncbi.nlm.nih.gov/8996208
https://pubmed.ncbi.nlm.nih.gov/8996208
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 279(1)
The objective of these studies was to determine if the immunotoxic effects of cocaine in mice are sex- and strain-dependent, a profile of activity previously described for cocaine-induced hepatotoxicity. The latter effect has been attributed to diffe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::27fda820f9c7621d6c695de96c9fedb7
https://pubmed.ncbi.nlm.nih.gov/8858969
https://pubmed.ncbi.nlm.nih.gov/8858969