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Inducible nitric oxide synthase in the rat testis: evidence for potential roles in both normal function and inflammation-mediated infertility

Autor: M K, O'Bryan, S, Schlatt, O, Gerdprasert, D J, Phillips, D M, de Kretser, M P, Hedger

Publikováno v: Biology of reproduction. 63(5)

In vitro data have indicated that nitric oxide (NO) inhibits Leydig cell testosterone production, suggesting that NO may play a role in the suppression of steroidogenesis and spermatogenic function during inflammation. Consequently, we investigated e

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::d17b9a29219157fb25fb0b51a3b0dfeb
https://pubmed.ncbi.nlm.nih.gov/11058531

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Differential actions of gonadotropin-releasing hormone and human chorionic gonadotropin on interstitial fluid volume and immunoglobulin G concentrations in adult rat testis

Autor: M P, Hedger, J A, Muir

Publikováno v: Journal of andrology. 21(5)

Gonadotropin-releasing hormone (GnRH) agonists regulate testicular interstitial fluid (tIF) volume, most probably via specific receptors on Leydig cells. The aim of this study was to confirm the interaction between GnRH and Leydig cells in regulation

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::92eaf75cc6c9f0e2f96e5f867dc88079
https://pubmed.ncbi.nlm.nih.gov/10975422

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Bacterial lipopolysaccharide-induced inflammation compromises testicular function at multiple levels in vivo

Autor: M K, O'Bryan, S, Schlatt, D J, Phillips, D M, de Kretser, M P, Hedger

Publikováno v: Endocrinology. 141(1)

While it is well known that serious illness and inflammation reduce male fertility, the mechanisms involved are poorly understood. In adult male rats, a single injection of lipopolysaccharide at doses that induced either mild or severe inflammation,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::853b344dcacc095388c8eff39e395a82
https://pubmed.ncbi.nlm.nih.gov/10614644

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Immunoregulatory activity in adult rat testicular interstitial fluid: roles of interleukin-1 and transforming growth factor beta

Autor: M P, Hedger, D J, Nikolic-Paterson, P, Hutchinson, R C, Atkins, D M, de Kretser

Publikováno v: Biology of reproduction. 58(4)

Studies on the effect of rat testicular interstitial fluid (IF) on T-cell function have reported both stimulatory and inhibitory actions. Specific cytokines produced within the testis, particularly interleukin-1 (IL-1) and transforming growth factor

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::ed418a2c17629292c49722fb1f6468d0
https://pubmed.ncbi.nlm.nih.gov/9546722

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Immunoregulatory activity in adult rat testicular interstitial fluid: relationship with intratesticular CD8+ lymphocytes following treatment with ethane dimethane sulfonate and testosterone implants

Autor: M P, Hedger, J, Wang, H Y, Lan, R C, Atkins, N G, Wreford

Publikováno v: Biology of reproduction. 58(4)

Regulation of T-cell traffic and function in the adult rat testis was assessed following treatment with the specific Leydig cell cytoxin, ethane dimethane sulfonate (EDS), and s.c. testosterone implants to prevent Leydig cell recovery. The distributi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::951d15167b81e1347cf3c0af512b8dbe
https://pubmed.ncbi.nlm.nih.gov/9546723

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Characterization of lymphocytes in the adult rat testis by flow cytometry: effects of activin and transforming growth factor beta on lymphocyte subsets in vitro

Autor: A B, Tompkins, P, Hutchinson, D M, de Kretser, M P, Hedger

Publikováno v: Biology of reproduction. 58(4)

The rat testis is considered to be an immunologically privileged site because of its reduced capacity to support antigen-specific immune responses. To understand this phenomenon, it is essential to characterize both the lymphocyte subpopulations norm

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::18dbce18be9b893c799aaeba9b650cdd
https://pubmed.ncbi.nlm.nih.gov/9546724

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Effect of chorionic gonadotropin and flutamide on Leydig cell and macrophage populations in the testosterone-estradiol-implanted adult rat

Autor: R J, Duckett, N G, Wreford, S J, Meachem, R I, McLachlan, M P, Hedger

Publikováno v: Journal of andrology. 18(6)

The objective of this study was to investigate the role of androgens and nonandrogenic Leydig cell products in maintaining Leydig cell and macrophage numbers in the testis of the adult rat. Adult male Sprague-Dawley rats received Silastic implants co

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::2db6757cb293a3ff627f30647511531c
https://pubmed.ncbi.nlm.nih.gov/9432138

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