Zobrazeno 1 - 10
of 73
pro vyhledávání: '"M P, Fisher"'
Publikováno v:
Royal Society Open Science, Vol 11, Iss 9 (2024)
The transcriptional machinery is essential for gene expression and regulation; dysregulation of transcription can result in a range of pathologies, including neurodegeneration, cancer, developmental disorders and cardiovascular disease. A key compone
Externí odkaz:
https://doaj.org/article/73a308574cb149d0b9df95ea024d723e
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 17 (2024)
Alzheimer’s disease (AD), Parkinson’s disease (PD), Frontotemporal Dementia (FTD), and Amyotrophic lateral sclerosis (ALS) are complex and fatal neurodegenerative diseases. While current treatments for these diseases do alleviate some symptoms, t
Externí odkaz:
https://doaj.org/article/e17d20a3bd9a4fafb822b2091a5e55fc
Autor:
Elisa M. Crombie, Andrea J. Korecki, Karen Cleverley, Bethany A. Adair, Thomas J. Cunningham, Weaverly Colleen Lee, Tess C. Lengyell, Cheryl Maduro, Victor Mo, Liam M. Slade, Ines Zouhair, Elizabeth M. C. Fisher, Elizabeth M. Simpson
Publikováno v:
Disease Models & Mechanisms, Vol 17, Iss 7 (2024)
Externí odkaz:
https://doaj.org/article/9121673d743d4e96a21019e14ea29d93
Autor:
Tara Canonica, Emma J. Kidd, Dorota Gibbins, Eva Lana-Elola, Elizabeth M. C. Fisher, Victor L. J. Tybulewicz, Mark Good
Publikováno v:
Frontiers in Behavioral Neuroscience, Vol 18 (2024)
BackgroundTrisomy of human chromosome 21 (Hsa21) results in a constellation of features known as Down syndrome (DS), the most common genetic form of intellectual disability. Hsa21 is orthologous to three regions in the mouse genome on mouse chromosom
Externí odkaz:
https://doaj.org/article/b395bf2008984e8eba2831c22e885ced
Autor:
Yixing Wu, Paige Mumford, Suzanna Noy, Karen Cleverley, Alicja Mrzyglod, Dinghao Luo, Floris van Dalen, Martijn Verdoes, Elizabeth M. C. Fisher, Frances K. Wiseman
Publikováno v:
Acta Neuropathologica Communications, Vol 11, Iss 1, Pp 1-19 (2023)
Abstract Cathepsin B is a cysteine protease that is implicated in multiple aspects of Alzheimer’s disease pathogenesis. The endogenous inhibitor of this enzyme, cystatin B (CSTB) is encoded on chromosome 21. Thus, individuals who have Down syndrome
Externí odkaz:
https://doaj.org/article/fdd398815b864621914e2872780af98c
Autor:
Zeinab Ali, Juan M. Godoy-Corchuelo, Aurea B. Martins-Bach, Irene Garcia-Toledo, Luis C. Fernández-Beltrán, Remya R. Nair, Shoshana Spring, Brian J. Nieman, Irene Jimenez-Coca, Rasneer S. Bains, Hamish Forrest, Jason P. Lerch, Karla L. Miller, Elizabeth M. C. Fisher, Thomas J. Cunningham, Silvia Corrochano
Publikováno v:
Disease Models & Mechanisms, Vol 16, Iss 10 (2023)
Externí odkaz:
https://doaj.org/article/3f0a2c5de56a43eca3efee6113651e7a
Autor:
Kourtney Sloan, Jared Thomas, Matthew Blackwell, Deanna Voisard, Eva Lana-Elola, Sheona Watson-Scales, Daniel L. Roper, Joseph M. Wallace, Elizabeth M. C. Fisher, Victor L. J. Tybulewicz, Randall J. Roper
Publikováno v:
Disease Models & Mechanisms, Vol 16, Iss 4 (2023)
Externí odkaz:
https://doaj.org/article/3bbbbb9016c543a4b1f805a022884fdf
Autor:
Abdallah M. Eteleeb, Prasanth K. Thunuguntla, Kyla Z. Gelev, Cynthia Y. Tang, Emily B. Rozycki, Alexander Miller, Jonathan T. Lei, Reyka G. Jayasinghe, Ha X. Dang, Nicole M. White, Jorge S. Reis-Filho, Elaine R. Mardis, Matthew J. Ellis, Li Ding, Jessica M. Silva-Fisher, Christopher A. Maher
Publikováno v:
npj Breast Cancer, Vol 8, Iss 1, Pp 1-12 (2022)
Abstract Late-stage relapse (LSR) in patients with breast cancer (BC) occurs more than five years and up to 10 years after initial treatment and has less than 30% 5-year relative survival rate. Long non-coding RNAs (lncRNAs) play important roles in B
Externí odkaz:
https://doaj.org/article/06f93b9f73504e1787c7cc91e8e64b0c
Autor:
Emily Buckingham, Jeffrey W. Streicher, M. Caitlin Fisher‐Reid, Tereza Jezkova, John J. Wiens
Publikováno v:
Ecology and Evolution, Vol 12, Iss 11, Pp n/a-n/a (2022)
Abstract In numerous clades, divergent sister species have largely non‐overlapping geographic ranges. This pattern presumably arises because species diverged in allopatry or parapatry, prior to a subsequent contact. Here, we provide population‐ge
Externí odkaz:
https://doaj.org/article/75a3e044ffd54eeb9c9ff419e12808d5
Autor:
Maria Giovanna Garone, Nicol Birsa, Maria Rosito, Federico Salaris, Michela Mochi, Valeria de Turris, Remya R. Nair, Thomas J. Cunningham, Elizabeth M. C. Fisher, Mariangela Morlando, Pietro Fratta, Alessandro Rosa
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-17 (2021)
Maria Giovanna Garone et al. use iPSC and mouse models to evaluate a mechanistic link between aberrant axonal phenotypes in ALS and the alteration of a cross-regulatory circuitry involving three RNA binding proteins: FUS, HuD and FMRP. Their results
Externí odkaz:
https://doaj.org/article/4355909082b145b69e7ada11d6280eeb