Zobrazeno 1 - 10
of 10
pro vyhledávání: '"M P, Fanucchi"'
Autor:
D. M. Hyde, L. A. Miller, E. S. Schelegle, M. V. Fanucchi, L. S. Van Winkle, N. K. Tyler, M. V. Avdalovic, M. J. Evans, R. Kajekar, A. R. Buckpitt, K. E. Pinkerton, J. P. Joad, L. J. Gershwin, R. Wu, C. G. Plopper
Publikováno v:
European Respiratory Review, Vol 15, Iss 101, Pp 122-135 (2006)
Asthma is a worldwide health problem that affects 300 million people, as estimated by the World Health Organization. A key question in light of this statistic is: "what is the most appropriate laboratory animal model for human asthma?" The present au
Externí odkaz:
https://doaj.org/article/2f3c593e59aa4693bff89c6dcf3e10b1
Autor:
E, Berman, R, Duigou-Osterndorf, S E, Krown, M P, Fanucchi, J, Chou, M S, Hirsch, B D, Clarkson, T C, Chou
Publikováno v:
Blood. 74:1281-1286
Azidothymidine (AZT) and interferon alpha (IFN-alpha) are among the drugs showing strong in vitro activity against the human immunodeficiency virus type-1 (HIV-1). Each drug, however, has significant toxicity against normal marrow progenitor cells th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dcfac7220dc986fc1017e306796690e8
https://doi.org/10.1182/blood.v74.4.1281.bloodjournal7441281
https://doi.org/10.1182/blood.v74.4.1281.bloodjournal7441281
Autor:
Pedro M. Vidal, A. Feinberg, Charles W. Young, M P Fanucchi, K. A. Watanabe, Brian Leyland-Jones, Jack J. Fox, L Williams, C Hancock, F. S. Philips
Publikováno v:
Antimicrobial agents and chemotherapy. 27(5)
The metabolism of the drug [2-14C]-1-(2'-deoxy-2'-fluoro-beta-D -arabinofuranosyl)-5-iodocytosine (FIAC), a potent inhibitor of herpesvirus replication, was studied in immunosuppressed patients with herpesvirus infections. FIAC was administered intra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dde4f42c4c14fe9ad8be3ffd97716638
https://pubmed.ncbi.nlm.nih.gov/2990323
https://pubmed.ncbi.nlm.nih.gov/2990323
Autor:
M P, Fanucchi, T D, Walsh, M, Fleisher, G, Lokos, L, Williams, C, Cassidy, P, Vidal, T C, Chou, D, Niedzwiecki, C W, Young
Publikováno v:
Cancer research. 47(12)
Trimetrexate, a new antifolate compound, was administered by 30-min infusions weekly for 3 weeks to 29 patients with solid tumors in a Phase I study. Thrombocytopenia was dose limiting, but highly variable among patients at a given dose level; other
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::b37dca92c645e523b219eb06e1750c62
https://pubmed.ncbi.nlm.nih.gov/2953412
https://pubmed.ncbi.nlm.nih.gov/2953412
Autor:
J R, Bertino, J T, Lin, A R, Cashmore, M P, Fanucchi, W P, Tong, J A, Stewart, J J, McCormack
Publikováno v:
Seminars in oncology. 15(2 Suppl 2)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::e4914a6fbe2b9289284ca3ddc3829d02
https://pubmed.ncbi.nlm.nih.gov/2966987
https://pubmed.ncbi.nlm.nih.gov/2966987
Autor:
M P, Fanucchi, J J, Kinahan, L L, Samuels, C, Hancock, T C, Chou, D, Niedzwiecki, F, Farag, P M, Vidal, J I, DeGraw, S S, Sternberg
Publikováno v:
Cancer research. 47(9)
10-Ethyl-10-deazaaminopterin (10-EdAM) is an antifolate compound with greater therapeutic activity than methotrexate against transplanted tumors in mice. When given weekly for 3 weeks, the 10% lethal dose in rats was 125 mg/kg (i.p.) and in dogs it w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::78b61d37260a559fb7e26cbe7aa039b3
https://pubmed.ncbi.nlm.nih.gov/2436760
https://pubmed.ncbi.nlm.nih.gov/2436760
Publikováno v:
Cancer treatment reports. 69(1)
1-(2'-Deoxy-2'-fluoro-1-beta-D-arabinofuranosyl)-5-methyluracil (FMAU), a new pyrimidine nucleoside, is of potential clinical interest both as an anticancer and as an antiviral drug. FMAU is active in vitro and in vivo against P815 and L1210 cell lin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::a4b5db0fdd70ce5618190cfd4174f3bb
https://pubmed.ncbi.nlm.nih.gov/2981621
https://pubmed.ncbi.nlm.nih.gov/2981621
Autor:
M G, Kris, J J, Kinahan, R J, Gralla, M P, Fanucchi, M S, Wertheim, J P, O'Connell, L D, Marks, L, Williams, F, Farag, C W, Young
Publikováno v:
Cancer research. 48(19)
10-Ethyl-10-deazaaminopterin (10-EDAM) is an analogue of methotrexate with improved preclinical anticancer activity, more selective entry, and greater conversion to polyglutamate forms in neoplastic cells. In this Phase I trial, we have treated 62 ad
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::b0f1ad5f4cf295f778d2daf0f7db7500
https://pubmed.ncbi.nlm.nih.gov/3416310
https://pubmed.ncbi.nlm.nih.gov/3416310
Autor:
Yung-Chi Cheng, Jack J. Fox, Xiang-Bin Kong, Ting-Chao Chou, Kiyobumi Takahashi, M. P. Fanucchi, Kyoichi A. Watanabe
2'-Fluoro-5-ethyl-1-beta-D-arabinofuranosyluracil (FEAU) was synthesized, and its biological activities were compared with those of 2'-fluoro-5-methyl-1-beta-D-arabinofuranosyluracil (FMAU). Earlier studies indicated that both compounds showed potent
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3375ac4d0c21dbc5d7b62af8163b8b2e
Autor:
C W, Young, M P, Fanucchi, T, Declan Walsh, L, Baltzer, S, Yaldaei, Y W, Stevens, C, Gordon, W, Tong, R A, Rifkind, P A, Marks
Publikováno v:
Cancer research. 48(24 Pt 1)
We have treated 33 patients with different types of advanced cancer by 10-day continuous i.v. infusion courses of hexamethylene bisacetamide (HMBA), a drug that produces differentiation of a variety of transformed cell lines on prolonged exposure in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::d2adf6a5fa54169479b27a612e25c173
https://pubmed.ncbi.nlm.nih.gov/3191501
https://pubmed.ncbi.nlm.nih.gov/3191501