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RNAi screens reveal novel metabolic regulators: RIP140, MAP4k4 and the lipid droplet associated fat specific protein (FSP) 27

Autor: V, Puri, J V, Virbasius, A, Guilherme, M P, Czech

Publikováno v: Acta physiologica (Oxford, England). 192(1)

Adipose tissue modulates whole body metabolism and insulin sensitivity by controlling circulating lipid levels and producing molecules that can regulate fatty acid metabolism in such tissues as muscle and liver. We have developed RNA interference (RN

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::dca383a5a9eb7f16947e1ec33cc10958
https://pubmed.ncbi.nlm.nih.gov/18171433

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Isolation and properties of GRP1, an ADP-ribosylation factor (ARF)-guanine nucleotide exchange protein regulated by phosphatidylinositol 3,4,5-trisphosphate

Autor: J K, Klarlund, M P, Czech

Publikováno v: Methods in enzymology. 329

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::cc216c4d77efba7075086e9d2f845829
https://pubmed.ncbi.nlm.nih.gov/11210545

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PIP2 and PIP3: complex roles at the cell surface

Autor: M P, Czech

Publikováno v: Cell. 100(6)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::f887b0846f26b39b67f706566eebf8c4
https://pubmed.ncbi.nlm.nih.gov/10761925

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Effects of general receptor for phosphoinositides 1 on insulin and insulin-like growth factor I-induced cytoskeletal rearrangement, glucose transporter-4 translocation, and deoxyribonucleic acid synthesis

Autor: M, Clodi, P, Vollenweider, J, Klarlund, N, Nakashima, S, Martin, M P, Czech, J M, Olefsky

Publikováno v: Endocrinology. 139(12)

We investigated the effects of general receptor for phosphoinositides-1 (GRP1), a recently cloned protein that binds 3,4,5-phosphatidylinositol [PtdIns(3,4,5)P3] with high affinity, but not PtdIns(3,4)P2 nor PtdIns(3)P, on insulin and insulin-like gr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::e8302005c03640b04a4c96978e00e4e6
https://pubmed.ncbi.nlm.nih.gov/9832437

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Pericentriolar targeting of GDP-dissociation inhibitor isoform 2

Autor: A, Shisheva, S J, Doxsey, J M, Buxton, M P, Czech

Publikováno v: European journal of cell biology. 68(2)

Cellular mechanisms for regulating membrane movements appear to involve small GTPases of the Rab subfamily. Binding of GDP-bound Rab proteins to donor membranes and their release from target membranes appear to be regulated by GDP-dissociation inhibi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::3b9e18b57b61e14dd3c54c098585cf30
https://pubmed.ncbi.nlm.nih.gov/8575461

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Disassembly of Son-of-sevenless proteins from Grb2 during p21ras desensitization by insulin

Autor: A D, Cherniack, J K, Klarlund, B R, Conway, M P, Czech

Publikováno v: The Journal of biological chemistry. 270(4)

Insulin receptor signaling acutely stimulates GTP loading of p21ras, apparently by mobilizing complexes of Grb2 and the guanine nucleotide exchangers Son-of-sevenless (Sos) 1 and 2 to associate with tyrosine-phosphorylated proteins in the plasma memb

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::98d7feb0d2fafdd3dd5af8f57f018d8f
https://pubmed.ncbi.nlm.nih.gov/7829473

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Regulation by insulin of phosphatidylinositol 3'-kinase bound to alpha- and beta-isoforms of p85 regulatory subunit

Autor: K, Baltensperger, L M, Kozma, S R, Jaspers, M P, Czech

Publikováno v: The Journal of biological chemistry. 269(46)

The roles of the alpha- and beta-isoforms of phosphatidylinositol (PI) 3'-kinase p85 regulatory subunit were studied with isoform-specific antisera in three model systems in which the insulin receptor mediates rapid phosphorylation of insulin recepto

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::9ab980938246f872e7e3e4ac36a9072a
https://pubmed.ncbi.nlm.nih.gov/7961856

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Differential intracellular localizations of GDP dissociation inhibitor isoforms. Insulin-dependent redistribution of GDP dissociation inhibitor-2 in 3T3-L1 adipocytes

Autor: A, Shisheva, J, Buxton, M P, Czech

Publikováno v: The Journal of biological chemistry. 269(39)

Insulin action on fat cell/skeletal muscle glucose transporter (GLUT4) redistribution to cell surface membranes appears to involve small GTP-binding proteins. It has been recently recognized that at least two GDP dissociation inhibitor (GDI) isoforms

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::f123ca34956842eac295be173a04a62a
https://pubmed.ncbi.nlm.nih.gov/7929030

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Phosphorylation of the Ras nucleotide exchange factor son of sevenless by mitogen-activated protein kinase

Autor: A D, Cherniack, J K, Klarlund, M P, Czech

Publikováno v: The Journal of biological chemistry. 269(7)

Son of sevenless-1 and -2 (Sos-1 and -2) are guanosine nucleotide exchange factors implicated in the activation of Ras by both the insulin and epidermal growth factor signal transduction pathways. Ras appears to function by initiating the activation

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::fefd62846382032e8f05a6fe22dcc9b1
https://pubmed.ncbi.nlm.nih.gov/8106439

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