A transcriptomic based deconvolution framework for assessing differentiation stages and drug responses of AML

Autor: E. Onur Karakaslar, Jeppe F. Severens, Elena Sánchez-López, Peter A. van Veelen, Mihaela Zlei, Jacques J. M. van Dongen, Annemarie M. Otte, Constantijn J. M. Halkes, Peter van Balen, Hendrik Veelken, Marcel J. T. Reinders, Marieke Griffioen, Erik B. van den Akker

Publikováno v: npj Precision Oncology, Vol 8, Iss 1, Pp 1-11 (2024)

Abstract The diagnostic spectrum for AML patients is increasingly based on genetic abnormalities due to their prognostic and predictive value. However, information on the AML blast phenotype regarding their maturational arrest has started to regain i

Externí odkaz: https://doaj.org/article/21d4317eb7704a259707b43c5a1bffc6

Air pollution and childhood epilepsy diagnosis at a first seizure clinic in The Netherlands: A case-control study

Autor: Geertruida Slinger, Sien T. Verbeek, Eric van Diessen, Lotte Noorlag, Kees P.J. Braun, Youchen Shen, Willem M. Otte, George S. Downward

Publikováno v: Environmental Advances, Vol 16, Iss , Pp 100541- (2024)

Increasing evidence suggests that exposure to air pollution is linked to neurological disorders, but little is known about the association with epilepsy. This study aimed to quantify the association between exposure to ambient air pollutants and the

Externí odkaz: https://doaj.org/article/a4a9ad49dfa04a1f9f8f85294a9a5cdb

An RNA Motif That Enables Optozyme Control and Light‐Dependent Gene Expression in Bacteria and Mammalian Cells

Autor: Georg Pietruschka, Américo T. Ranzani, Anna Weber, Tejal Patwari, Sebastian Pilsl, Christian Renzl, David M. Otte, Daniel Pyka, Andreas Möglich, Günter Mayer

Publikováno v: Advanced Science, Vol 11, Iss 12, Pp n/a-n/a (2024)

Abstract The regulation of gene expression by light enables the versatile, spatiotemporal manipulation of biological function in bacterial and mammalian cells. Optoribogenetics extends this principle by molecular RNA devices acting on the RNA level w

Externí odkaz: https://doaj.org/article/0b5e94232b5f4f0da9d2e77feec018fa

Frequency of and factors associated with antiseizure medication discontinuation discussions and decisions in patients with epilepsy: A multicenter retrospective chart review

Autor: Samuel W. Terman, Geertruida Slinger, Adriana Koek, Jeremy Skvarce, Mellanie V. Springer, Julie M. Ziobro, James F. Burke, Willem M. Otte, Roland D. Thijs, Kees P. J. Braun

Publikováno v: Epilepsia Open, Vol 8, Iss 2, Pp 371-385 (2023)

Abstract Objective Guidelines suggest considering antiseizure medication (ASM) discontinuation in patients with epilepsy who become seizure‐free. Little is known about how discontinuation decisions are being made in practice. We measured the freque

Externí odkaz: https://doaj.org/article/34779060cbd8485f81eef5845af38055

Overview of the first Wendelstein 7-X long pulse campaign with fully water-cooled plasma facing components

Autor: O. Grulke, C. Albert, J.A. Alcuson Belloso, P. Aleynikov, K. Aleynikova, A. Alonso, G. Anda, T. Andreeva, M. Arvanitou, E. Ascasibar, E. Aymerich, K. Avramidis, J.-P. Bähner, S.-G. Baek, M. Balden, J. Baldzuhn, S. Ballinger, M. Banduch, S. Bannmann, A. Bañón Navarro, L. Baylor, C.D. Beidler, M. Beurskens, C. Biedermann, G. Birkenmeier, T. Bluhm, D. Boeckenhoff, D. Boeyaert, D. Bold, M. Borchardt, D. Borodin, H.-S. Bosch, H. Bouvain, S. Bozhenkov, T. Bräuer, H. Braune, C. Brandt, S. Brezinsek, K.J. Brunner, C. Büschel, R. Bussiahn, A. Buzás, B. Buttenschoen, V. Bykov, I. Calvo, A. Cappa, F. Carovani, D. Carralero, A. Carls, B. Carvalho, D. Castaño-Bardawil, N. Chaudhary, I. Chelis, S. Chen, D. Cipciar, J.W. Coenen, G. Conway, M. Cornelissen, Y. Corre, P. Costello, K. Crombe, G. Cseh, B. Csillag, H.I. Cu Castillo, G. Czymek, H. Damm, R.J. Davies, C. Day, S. Degenkolbe, R. De Wolf, W. Dekeyser, A. Demby, P. Despontin, C.P. Dhard, A. Dinklage, F.A. d’Isa, T. Dittmar, M. Dreval, M. Drevlak, P. Drews, J. Droste, D. Dunai, C. Dyhring, P. van Eeten, E. Edlund, M. Endler, D.A. Ennis, F.J. Escoto, M.S. Espinosa, T. Estrada, D. Fehling, L. Feuerstein, J. Fellinger, Y. Feng, D.L.C. Fernando, S. Fischer, E.R. Flom, O. Ford, T. Fornal, J. Frank, H. Frerichs, G. Fuchert, G. Gantenbein, Y. Gao, K. Garcia, I. García-Cortés, J.M. García-Regaña, B. Geiger, J. Geiger, P. Geissler, M. Gerard, G. Godino-Sedano, T. Gonda, A. González, A. Goriaev, D. Gradic, M. Grahl, H. Greuner, E. Grigore, M. Gruca, J.F. Guerrero Arnaiz, V. Haak, L. van Ham, K. Hammond, B. Hamstra, X. Han, S.K. Hansen, J. Harris, D. Hartmann, D. Hathiramani, S. Hegedus, S. Heinrich, P. Helander, F. Henke, S. Henneberg, L. Henschke, M. Hirsch, U. Hoefel, K. Hoefler, S. Hoermann, K.-P. Hollfeld, A. Holtz, D. Höschen, M. Houry, J. Huang, M. Hubeny, K. Hunger, D. Hwangbo, K. Ida, Y. Igitkhanov, S. Illy, Z. Ioannidis, M. Jablczynska, S. Jablonski, B. Jabłoński, B. Jagielski, M. Jakubowski, J. Jelonnek, F. Jenko, J. Jin, A. Johansson, G. Jouniaux, S. Kajita, J.-P. Kallmeyer, U. Kamionka, W. Kasparek, C. Kawan, Ye. O. Kazakov, N. Kenmochi, W. Kernbichler, A.K. Kharwandikar, M. Khokhlov, C. Killer, A. Kirschner, R. Kleiber, C.C. Klepper, T. Klinger, J. Knauer, A. Knieps, M. Kobayashi, G. Kocsis, Y. Kolesnichenko, A. Könies, J. Kontula, P. Kornejew, S.A. Korteweg, J. Koschinsky, J. Koster, Y. Kovtun, A. Krämer-Flecken, M. Krause, T. Kremeyer, L. Krier, D.M. Kriete, M. Krychowiak, I. Ksia¸zek, M. Kubkowska, M.D. Kuczyński, D. Kulla, A. Kumar, T. Kurki-Suonio, I. Kuzmych, S. Kwak, V. Lancelotti, A. Langenberg, H. Laqua, H.P. Laqua, M.R. Larsen, S. Lazerson, C. Lechte, B. Lee, A. LeViness, M. Lewerentz, Y. Liang, L. Liao, A. Litnovsky, J. Liu, J. Loizu, R. Lopez-Cansino, L.D. Lopez Rodriguez, A. Lorenz, R. Lunsford, Y. Luo, V. Lutsenko, N. Maaziz, M. Machielsen, R. Mackenbach, D. Makowski, E. Maragkoudakis, O. Marchuk, M. Markl, S. Marsen, J. Martínez, N. Marushchenko, S. Masuzaki, D.A. Maurer, M. Mayer, K.J. McCarthy, P. McNeely, D. Medina Roque, J. Meineke, S. Meitner, S. vaz Mendes, A. Menzel-Barbara, B. van Milligen, A. Mishchenko, V. Moiseenko, A. Möller, S. Möller, D. Moseev, G. Motojima, S. Mulas, P. Mulholland, M. Nagel, D. Nagy, Y. Narbutt, D. Naujoks, P. Nelde, R. Neu, O. Neubauer, U. Neuner, D. Nicolai, S. Nielsen, C. Nührenberg, R. Ochoukov, G. Offermanns, J. Ongena, J.W. Oosterbeek, M. Otte, N. Pablant, N. Panadero Alvarez, A. Pandey, G. Partesotti, E.A. Pasch, R. Pavlichenko, E. Pawelec, T.S. Pedersen, V. Perseo, B. Peterson, F. Pisano, B. Plaum, G. Plunk, L. Podavini, N.S. Polei, P. Poloskei, S. Ponomarenko, P. Pons-Villalonga, M. Porkolab, J. Proll, M.J. Pueschel, A. Puig Sitjes, R. Ragona, K. Rahbarnia, M. Rasiński, J. Rasmussen, D. Refy, F. Reimold, M. Richou, J.S. Riemann, K. Riße, J. de la Riva Villén, G. Roberg-Clark, E. Rodriguez, V. Rohde, J. Romazanov, T. Romba, D. Rondeshagen, M. Rud, T. Ruess, T. Rummel, A. Runov, C. Ruset, N. Rust, L. Ryc, T. Rzesnicki, M. Salewski, E. Sánchez, L. Sanchis Sanchez, G. Satheeswaran, J. Schacht, E. Scharff, J. Schilling, G. Schlisio, K. Schmid, J.C. Schmitt, O. Schmitz, M. Schneider, M. Van Schoor, T. Schröder, R. Schroeder, B. Schweer, S. Sereda, B. Shanahan, G. Sias, S. Simko, L. Singh, Y. Siusko, C. Slaby, M. Śle¸czka, B.S. Smith, D.R. Smith, H. Smith, M. Spolaore, A. Spring, T. Stange, A. von Stechow, I. Stepanov, M. Stern, U. Stroth, Y. Suzuki, C. Swee, L. Syrocki, T. Szabolics, T. Szepesi, R. Takacs, H. Takahashi, N. Tamura, C. Tantos, J. Terry, S. Thiede, H. Thienpondt, H. Thomsen, M. Thumm, T. Thun, S. Togo, T. Tork, H. Trimino Mora, A. Tsikouras, Y. Turkin, L. Vano, S. Varoutis, M. Vecsei, J.L. Velasco, M. Verstraeten, M. Vervier, E. Viezzer, J. Wagner, E. Wang, F. Wang, M. Wappl, F. Warmer, T. Wegner, Y. Wei, G. Weir, N. Wendler, U. Wenzel, A. White, F. Wilms, T. Windisch, A. Winter, V. Winters, R. Wolf, G. Wurden, P. Xanthopoulos, H.M. Xiang, S. Xu, H. Yamada, J. Yang, R. Yi, M. Yokoyama, B. Zamorski, M. Zanini, M. Zarnstorff, D. Zhang, S. Zhou, J. Zhu, J. Zimmermann, A. Zocco, S. Zoletnik

Publikováno v: Nuclear Fusion, Vol 64, Iss 11, p 112002 (2024)

After a long device enhancement phase, scientific operation resumed in 2022. The main new device components are the water cooling of all plasma facing components and the new water-cooled high heat flux divertor units. Water cooling allowed for the fi

Externí odkaz: https://doaj.org/article/a05e816389844ac18f2fb63da24bc4a7