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PKCδ regulates chromatin remodeling and DNA repair through SIRT6

Autor: Trisiani Affandi, Ami Haas, Angela M. Ohm, Gregory M. Wright, Joshua C. Black, Mary E. Reyland

Publikováno v: bioRxiv

Protein kinase C delta (PKCδ) is a ubiquitous kinase whose function is defined in part by localization to specific cellular compartments. Nuclear PKCδ is both necessary and sufficient for IR-induced apoptosis, while inhibition of PKCδ activity pro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d815da4e55e43349ae1912bb5ae7c69c
https://europepmc.org/articles/PMC10245827/

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Akademický článek

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Supplemental Figures from Loss of MAP3K7 Sensitizes Prostate Cancer Cells to CDK1/2 Inhibition and DNA Damage by Disrupting Homologous Recombination

Autor: Scott D. Cramer, James C. Costello, Mary E. Reyland, Elaine T. Lam, Angela M. Ohm, Trisiani Affandi, Lauren K. Jillson, Lina Romero, Leah C. Rider, Satoshi Washino

The supplemental figures provide supporting data including controls, synergism studies, dose response curves, validation of knockdown, etc.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::25077f8deb042f3bf4d87b542a36cf11
https://doi.org/10.1158/1541-7786.22516180

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Supplementary Tables 1-9, 11, 13-15 from Loss of MAP3K7 Sensitizes Prostate Cancer Cells to CDK1/2 Inhibition and DNA Damage by Disrupting Homologous Recombination

Autor: Scott D. Cramer, James C. Costello, Mary E. Reyland, Elaine T. Lam, Angela M. Ohm, Trisiani Affandi, Lauren K. Jillson, Lina Romero, Leah C. Rider, Satoshi Washino

Tables s1-9, 11, 13-15. These tables provide statistical data, gene list, and results from TRAP and GSEA that support the conclusions of the manuscript and provide full disclosure of our results.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c02b6620be723b42d3c24c660c8be6d
https://doi.org/10.1158/1541-7786.22516171

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Supplementary Table 10 from Loss of MAP3K7 Sensitizes Prostate Cancer Cells to CDK1/2 Inhibition and DNA Damage by Disrupting Homologous Recombination

Autor: Scott D. Cramer, James C. Costello, Mary E. Reyland, Elaine T. Lam, Angela M. Ohm, Trisiani Affandi, Lauren K. Jillson, Lina Romero, Leah C. Rider, Satoshi Washino

Table S10 shows IC50 and statistical data from several drugs tested that are presented in figure 1

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b6813d9f727e9c70c255ee37cc8921f
https://doi.org/10.1158/1541-7786.22516177.v1

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Data from Loss of MAP3K7 Sensitizes Prostate Cancer Cells to CDK1/2 Inhibition and DNA Damage by Disrupting Homologous Recombination

Autor: Scott D. Cramer, James C. Costello, Mary E. Reyland, Elaine T. Lam, Angela M. Ohm, Trisiani Affandi, Lauren K. Jillson, Lina Romero, Leah C. Rider, Satoshi Washino

The combined loss of CHD1 and MAP3K7 promotes aggressive prostate cancer by unknown mechanisms. Because both of these genes are lost genetically in prostate cancer, they cannot be directly targeted. We applied an established computational systems pha

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::39e63b2741d6a09a4342f357bd483437
https://doi.org/10.1158/1541-7786.c.6541303

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Supplementary Figure 1 from Protein Kinase C δ Is a Downstream Effector of Oncogenic K-ras in Lung Tumors

Autor: Mary E. Reyland, Wilbur A. Franklin, Theresa A. Boyle, Lynn E. Heasley, Cristan J. Carter, Angela M. Ohm, Jennifer M. Symonds

Supplementary Figure 1 from Protein Kinase C δ Is a Downstream Effector of Oncogenic K-ras in Lung Tumors

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::853725122f5bb733255d42d040c307c6
https://doi.org/10.1158/0008-5472.22388292.v1

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Supplementary Figure 2 from Protein Kinase C δ Is a Downstream Effector of Oncogenic K-ras in Lung Tumors

Autor: Mary E. Reyland, Wilbur A. Franklin, Theresa A. Boyle, Lynn E. Heasley, Cristan J. Carter, Angela M. Ohm, Jennifer M. Symonds

Supplementary Figure 2 from Protein Kinase C δ Is a Downstream Effector of Oncogenic K-ras in Lung Tumors

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::01b10aa1afd0a09b47a4f3c607d8da40
https://doi.org/10.1158/0008-5472.22388289

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Supplementary Figure Legends 1-2 from Protein Kinase C δ Is a Downstream Effector of Oncogenic K-ras in Lung Tumors

Autor: Mary E. Reyland, Wilbur A. Franklin, Theresa A. Boyle, Lynn E. Heasley, Cristan J. Carter, Angela M. Ohm, Jennifer M. Symonds

Supplementary Figure Legends 1-2 from Protein Kinase C δ Is a Downstream Effector of Oncogenic K-ras in Lung Tumors

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6070edcc3c0cb1e726c71ea7ce0b06f1
https://doi.org/10.1158/0008-5472.22388283

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Protection against invasive meningococcal disease and vaccination policy in the Netherlands

Autor: M Ohm, M Knol, E Sanders, G Berbers

Publikováno v: European Journal of Public Health. 32

Background A rise in serogroup C invasive meningococcal disease (IMD-C) led to introduction of MenC vaccination in 2002 in the Netherlands at 14 months of age, accompanied by a mass-campaign for all children between 1 and 18 years (coverage 94%). Due

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::404dccb9c329cb5a1cab53b490474ac7
https://doi.org/10.1093/eurpub/ckac130.098

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