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TOK channels use the two gates in classical K + channels to achieve outward rectification

Autor: Rían W. Manville, Luis G. Cuello, Anthony Lewis, Steve A.N. Goldstein, M Oana Popa, Zoe A. McCrossan

Publikováno v: Lewis, A, McCrossan, Z A, Manville, R, Popa, O, Cuello, L & Goldstein, S 2020, ' TOK channels use the two gates in classical K + channels to achieve outward rectification ', FASEB Journal, vol. 34, no. 7, 0, pp. 8902-8919 . https://doi.org/10.1096/fj.202000545R

TOKs are outwardly rectifying K+ channels in fungi with two pore-loops and eight transmembrane spans. Here, we describe the TOKs from four pathogens that cause the majority of life-threatening fungal infections in humans. These TOKs pass large curren

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5cbb2072bbd4afdb401fa74fdbe09f6a
https://doi.org/10.1096/fj.202000545r

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TOK channels use the two gates in classical K

Autor: Anthony, Lewis, Zoe A, McCrossan, Rían W, Manville, M Oana, Popa, Luis G, Cuello, Steve A N, Goldstein

Publikováno v: FASEB J

TOKs are outwardly rectifying K(+) channels in fungi with two pore-loops and eight transmembrane spans. Here, we describe the TOKs from four pathogens that cause the majority of life-threatening fungal infections in humans. These TOKs pass large curr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::3c4335c60f0f0316df72e07c9c7c278f
https://pubmed.ncbi.nlm.nih.gov/32519783

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Cooperative effect of S4-S5 loops in domains D3 and D4 on fast inactivation of the Na+channel

Autor: Sigrid Bail, M. Oana Popa, Alexi K. Alekov, Frank Lehmann-Horn, Holger Lerche

Publikováno v: The Journal of Physiology. 561:39-51

Cytoplasmic S4‐S5 loops have been shown to be involved in fast inactivation of voltagegate di on channels. We studied mutations in these loops and their potential cooperative effects in domains D3 (N1151C, A1152C, I1160C/A) and D4 (F1473C, L1482C/A

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::cad3b32580abcf2b7cce5b1951db120a
https://doi.org/10.1113/jphysiol.2004.065912

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Variomics screen identifies the re-entrant loop of the calcium-activated chloride channel ANO1 that facilitates channel activation

Autor: Maria Velkova, Douglas S. Auld, Paul J. Groot-Kormelink, Michiel T. van Diepen, Kathryn Acheson, Martin Gosling, L. Alex Gaither, Nicole A. Renaud, Anke Bill, Sarah Lilley, M. Oana Popa, Hedaythul Choudhury, Abraham Gutierrez

Publikováno v: The Journal of biological chemistry. 290(2)

The calcium-activated chloride channel ANO1 regulates multiple physiological processes. However, little is known about the mechanism of channel gating and regulation of ANO1 activity. Using a high-throughput, random mutagenesis-based variomics screen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::055e50ff7a002cea1316c3e1abfa63db
https://pubmed.ncbi.nlm.nih.gov/25425649

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Efficient generation of neural stem cell-like cells from adult human bone marrow stromal cells

Autor: Holger Lerche, Jörg Fiedler, Andreas Hermann, Johannes Schwarz, Stefan Liebau, Martina Maisel, Regina Gastl, M. Oana Popa, Rolf E. Brenner, Alexander Storch, Bernhard O. Boehm

Clonogenic neural stem cells (NSCs) are self-renewing cells that maintain the capacity to differentiate into brain-specific cell types, and may also replace or repair diseased brain tissue. NSCs can be directly isolated from fetal or adult nervous ti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60362fe71438607604af512d6770adb1
https://resolver.caltech.edu/CaltechAUTHORS:20110920-150329915

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Abstract LB-205: The calcium activated chloride channel ANO1 promotes breast cancer progression by activating EGFR- and CAMK-signaling

Publikováno v: Cancer Research. 73:LB-205

Genomic alterations are the underlining cause of many human cancers: Amplified and overexpressed genes can drive neoplastic transformation and become essential survival factors for cancer cells. Thus, they represent promising targets for anti-cancer

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::539c9853042afd9f6b99cd24babf11f7
https://doi.org/10.1158/1538-7445.am2013-lb-205

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Modeling of Single Noninactivating Na+ Channels: Evidence for Two Open and Several Fast Inactivated States

Autor: Yu-Kai The, Jacqueline Fernandes, M. Oana Popa, Alexi K. Alekov, Jens Timmer, Holger Lerche

Publikováno v: Biophysical Journal. (10):3511-3522

Voltage-gated Na(+) channels play a fundamental role in the excitability of nerve and muscle cells. Defects in fast Na(+) channel inactivation can cause hereditary muscle diseases with hyper- or hypoexcitability of the sarcolemma. To explore the kine

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dcd6279c50b9bde3c17c7f7f8fefa351

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